ArticleThe journal of venomous animals and toxins including tropical diseases2019
Effects of copaiba oil on dermonecrosis induced by
Article in The journal of venomous animals and toxins including tropical diseases, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed, 13 citations in OpenAlex.
- Evaluation of the effects ofToxicology reports · 2022Article
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9 authors at 2 institutions in 4 countries.
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Abstract
backgroundAccidents caused by spiders of the genus
methodsCutaneous lesions were induced on the backs of rabbits by intradermal injection of
resultsCompared to the control group, the platelet count was reduced significantly in all groups inoculated with venom, accompanied by a decreased number of heterophils in the blood. The minimum necrotic dose (MND) was defined as 2.4 μg/kg. Topical treatment with copaiba oil demonstrated a differentiated healing profile: large skin lesions were observed 10 days after venom inoculation, whereas formation of a thick crust, without scarring was observed 30 days after venom inoculation. Histopathological analysis showed no significant difference after treatment. Nevertheless, the copaiba oil treatment induced a collagen distribution similar to control skin, in marked contrast to the group that received only the spider venom injection.
conclusionsWe conclude that copaiba oil may interfere in the healing process and thus propose it as a possible topical treatment for cutaneous lesions induced by
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