Evidence map›Paper›PMID 31130997›Full record

ArticleThe journal of venomous animals and toxins including tropical diseases2019

Nitro-Heterocyclic compounds induce apoptosis-like effects in

Daiane Barros Dias Mendonça, Renata Ellen Costa Silva, Fanny Palace-Berl, Cleusa Fh Takakura, Sandra Regina C Soares, Lucia Maria Almeida Braz, Leoberto Costa Tavares, Jose Angelo Lauletta Lindoso

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The journal of venomous animals and toxins including tropical diseases, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
2.2field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Leishmanicidal Activity of Guanidine Derivatives againstTropical medicine and infectious disease · 2023
    Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Daiane Barros Dias MendonçaLaboratory of Serum Epidemiology, Faculty of Medicine, University of São Paulo, São Paulo, SP, Brazil.
Renata Ellen Costa SilvaLaboratory of Serum Epidemiology, Faculty of Medicine, University of São Paulo, São Paulo, SP, Brazil.
Fanny Palace-BerlLaboratory of Planning and Development of Pharmaceuticals, Department of Biochemical-Pharmaceutical Technology, Faculty of Pharmacy, University of São Paulo, São Paulo, SP, Brazil.
Cleusa Fh TakakuraDepartment of Pathology, Faculty of Medicine, University of São Paulo, São Paulo, SP, Brazil.
Sandra Regina C SoaresLaboratory of Protozoology, Institute of Tropical Medicine, Faculty of Medicine, University of São Paulo, São Paulo, SP, Brazil.
Lucia Maria Almeida BrazLaboratory of Serum Epidemiology, Faculty of Medicine, University of São Paulo, São Paulo, SP, Brazil.
Leoberto Costa TavaresLaboratory of Planning and Development of Pharmaceuticals, Department of Biochemical-Pharmaceutical Technology, Faculty of Pharmacy, University of São Paulo, São Paulo, SP, Brazil.
Jose Angelo Lauletta LindosoLaboratory of Serum Epidemiology, Faculty of Medicine, University of São Paulo, São Paulo, SP, Brazil.ORCID 0000-0002-4405-4401
Universidade de São Paulo · BRInstituto de Infectologia Emílio Ribas · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThree drugs - pentavalent antimonials, amphotericin B and pentamidine - are currently used for leishmaniasis treatment. They are administered for long periods, only parenterally, and have high cardiac, renal and hepatic toxicities. Therefore, the investigation of new compounds is required. Nitro-heterocyclic derivatives have been used as possible drug candidates to treat diseases caused by trypanosomatids.

methods

resultsEC

conclusionsNitro-heterocyclic compounds have shown activity against promastigotes of

Indexed as

Leishmania (L.) amazonensisLeishmaniasis treatmentNitro-heterocyclic compounds

Identifiers

PMID31130997
PMCPMC6521708
OpenAlexW2921306559

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.