ArticleFrontiers in genetics2019
Causal Effects of Genetically Predicted Cardiovascular Risk Factors on Chronic Kidney Disease: A Two-Sample Mendelian Randomization Study.
Article in Frontiers in genetics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 38 citations in OpenAlex.
- Causal role of the plasma lipidome in the occurrence and progression of chronic kidney disease: a two-sample Mendelian randomization study.Diabetology & metabolic syndrome · 2025Article
- Mendelian Randomization Studies: Opening a New Window in the Study of Metabolic Diseases and Chronic Kidney Disease.Endocrine, metabolic & immune disorders drug targets · 2025Review
- Recent advances in the application of Mendelian randomization to chronic kidney disease.Renal failure · 2024Review
- The Impact of Different Intensities of Physical Activity on Serum Urate and Gout: A Mendelian Randomization Study.Metabolites · 2024Article
- Understanding the relationship between circulating lipids and risk of chronic kidney disease: a prospective cohort study and large-scale genetic analyses.Journal of translational medicine · 2023Article
- High-density lipoprotein revisited: biological functions and clinical relevance.European heart journal · 2023Review
- Genetically Predicted Differences in Systolic Blood Pressure and Risk of Cardiovascular and Noncardiovascular Diseases: A Mendelian Randomization Study in Chinese Adults.Hypertension (Dallas, Tex. : 1979) · 2023Article
- Article
- Can Intelligence Affect Alcohol-, Smoking-, and Physical Activity-Related Behaviors? A Mendelian Randomization Study.Journal of Intelligence · 2023Article
- The association of serum magnesium and chronic kidney disease: a two-sample mendelian randomization study of European descent.European journal of clinical nutrition · 2022Article
- Trans-ethnic Mendelian-randomization study reveals causal relationships between cardiometabolic factors and chronic kidney disease.International journal of epidemiology · 2022Article
- Putative Candidate Drug Targets for Sarcopenia-Related Traits Identified Through Mendelian Randomization Analysis of the Blood Proteome.Frontiers in genetics · 2022Article
- Estimating causal effects of atherogenic lipid-related traits on COVID-19 susceptibility and severity using a two-sample Mendelian randomization approach.BMC medical genomics · 2021Article
- High-Density Lipoproteins in Kidney Disease.International journal of molecular sciences · 2021Review
- Article
- Causal effect between total cholesterol and HDL cholesterol as risk factors for chronic kidney disease: a mendelian randomization study.BMC nephrology · 2021Article
- Genome-Wide Association Studies of CKD and Related Traits.Clinical journal of the American Society of Nephrology : CJASN · 2020Review
- Association of Blood Pressure With Cause-Specific Mortality in Mexican Adults.JAMA network open · 2020Article
- A bidirectional Mendelian randomization study supports causal effects of kidney function on blood pressure.Kidney international · 2020Article
- Impaired fasting glucose and development of chronic kidney disease in non-diabetic population: a Mendelian randomization study.BMJ open diabetes research & care · 2020Article
Corrections and comments
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Authors and funding
10 authors at 4 institutions in 2 countries.
Funding
Abstract
Observational studies have demonstrated that cardiovascular risk factors are associated with chronic kidney disease (CKD). However, these observational associations are potentially influenced by the residual confounding, including some unmeasured lifestyle factors and interaction risk factors. Two-sample mendelian randomization analysis was conducted in this study to evaluate whether genetically predicted cardiovascular risk factors have a causal effect on the risk of CKD. We selected genetic variants associated with cardiovascular risk factors and extracted the corresponding effect sizes from the largest GWAS summary-level dataset of CKD. Cardiovascular risk factors contain high density lipoprotein (HDL) cholesterol, low density lipoprotein (LDL) cholesterol, total cholesterol (TC), triglyceride (TG), glycated hemoglobin (HbA1c), fasting glucose, systolic blood pressure (SBP) and diastolic blood pressure (DBP). A Bonferroni corrected threshold of
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.