Evidence map›Paper›PMID 31130946›Full record

ArticleFrontiers in immunology2019

Parenteral Vaccination With a Tuberculosis Subunit Vaccine in Presence of Retinoic Acid Provides Early but Transient Protection to

Antonella Riccomi, Giovanni Piccaro, Dennis Christensen, Carla Palma, Peter Andersen, Silvia Vendetti

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 24 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Antonella RiccomiDepartment of Infectious Diseases, Istituto Superiore di Sanità, Rome, Italy.
Giovanni PiccaroNotified Body, Istituto Superiore di Sanità, Rome, Italy.
Dennis ChristensenDepartment of Infectious Diseases Immunology, Statens Serum Institute, Copenhagen, Denmark.
Carla PalmaDepartment of Infectious Diseases, Istituto Superiore di Sanità, Rome, Italy.
Peter AndersenDepartment of Infectious Diseases Immunology, Statens Serum Institute, Copenhagen, Denmark.
Silvia VendettiDepartment of Infectious Diseases, Istituto Superiore di Sanità, Rome, Italy.
Istituto Superiore di Sanità · ITStatens Serum Institut · DK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Most microbes invading through mucosal surfaces cause disease and therefore strategies to induce mucosal immune responses are strongly needed. Vitamin A metabolites, such as retinoic acid (RA), play crucial roles in programming T and B cells to home to mucosal compartments, therefore we evaluated the capacity of RA to elicit mucosal immune responses against tuberculosis (TB) after parenteral vaccination. We found that mice immunized through subcutaneous injections with the TB subunit vaccine (CAF01+H56) in presence of RA show enhanced mucosal H56-specific IgA responses and enhanced Ag-specific CD4

Indexed as

Immunity, MucosalAllergensAnimalsAntibodies, BacterialAntibody-Producing CellsCD4-Positive T-LymphocytesCytokinesFemaleImmunoglobulin AImmunoglobulin GLungLymphocytesMiceMycobacterium tuberculosisOvalbuminTretinoinAllergensAntibodies, BacterialCytokinesImmunoglobulin AImmunoglobulin GOvalbuminTretinoinTuberculosis VaccinesVaccines, SubunitadjuvantM. tuberculosismucosal adjuvantmucosal immunitymucosal immunizationparenteral immunizationretinoic acid

Identifiers

PMID31130946
PMCPMC6509564
OpenAlexW2943585777

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.