ArticleIndian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine2019
Identification and Assessment of Potential Drug-Drug Interactions in Intensive Care Unit Patients.
Article in Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.
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Who cites it
6 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Heterogeneity in the Identification of Potential Drug-Drug Interactions in the Intensive Care Unit: A Systematic Review, Critical Appraisal, and Reporting Recommendations.Journal of clinical pharmacology · 2022Pooled it
- Drug-drug-interactions in patients with atrial fibrillation admitted to the emergency department.Frontiers in pharmacology · 2024Article
- Drug Utilization and Potential Drug-Drug Interactions within an Intensive Care Unit at a University Tertiary Care Hospital in Egypt.Pharmacy (Basel, Switzerland) · 2022Article
- Potential drug interactions in adults living in the Brazilian Amazon: A population-based case-control study, 2019.Exploratory research in clinical and social pharmacy · 2021Article
- Evaluation of drug information resources for interactions between therapeutic drugs and drugs of abuse.Journal of the Medical Library Association : JMLA · 2020Article
- Are We fulfilling the Hippocratic Oath?Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine · 2019Article
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5 authors.
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Abstract
contextIntensive care unit (ICU) patients suffer from various comorbidities and usually receive complex pharmacotherapy which increases the risk of drug-drug interactions (DDIs).
aimTo identify and assess potential DDIs (pDDIs) in ICU patients. SETTINGS AND
designA prospective observational study conducted in ICU of a tertiary care hospital for a period of 6 months. MATERIALS AND
methodsPatient information was noted in the data collection form and pDDIs were assessed using Micromedex®database. STATISTICAL ANALYSIS USED: Chi-square test was used to find correlation of pDDIs with patient parameters.
resultsTotal 400 subjects were included; having an average age of 55.99 ± 15.62 years with a higher percentage of males (61.75%). About 305 (76.25%) patients were found with pDDIs, showing an average of 2.93 pDDIs/patient. The findings of this study were as follows: Total interactions = 1171, contraindicated = 6 (1%), major = 715 (61%), moderate = 428 (36%), and minor = 22 (2%) pDDIs. Further, majority of pDDIs had onset of action "not specified" documentation "fair" and probable mechanism "pharmacodynamic" in nature. Significant association of occurrence of pDDIs was found with number of drugs prescribed to patients in ICU.
conclusionThis study demonstrated a high prevalence of pDDI in ICU due to the complexity of pharmacotherapy which showed major pDDIs as the most evident (61%) while contraindicated were 1%. Further studies are needed to better explore this area which may help in realizing the goal of good clinical practice and may offer a methodology to further increase drug safety. KEY MESSAGES: "Monitoring and assessment of DDIs is needed for better patient care". HOW TO CITE THIS ARTICLE: Wagh BR, Godbole DD,
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