Evidence map›Paper›PMID 31130779›Full record

ReviewJournal of molecular endocrinology2019

Mechanisms for Sex Differences in Energy Homeostasis.

Chunmei Wang, Yong Xu

Open access · bronzeAbstract readReview
In one paragraph

Review in Journal of molecular endocrinology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
43citing papers in PubMed, 1 pooled it
3.3field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

43 citing papers in PubMed, 1 synthesis or guideline pooled it, 87 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Review
  5. Article
  6. Vitamin D is glucoprotective in aging males but not females.The Journal of steroid biochemistry and molecular biology · 2026
    Article
  7. Article
  8. Article
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  11. Review
  12. Article
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  17. Article
  18. Article
  19. Review
  20. Sex-Gender-Based Differences in Metabolic Diseases.Handbook of experimental pharmacology · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Chunmei WangDepartment of Pediatrics, Children's Nutrition Research Center, Baylor College of Medicine, Houston, Texas, USA.
Yong XuDepartment of Pediatrics, Children's Nutrition Research Center, Baylor College of Medicine, Houston, Texas, USA.
Baylor College of Medicine · USChildren's Nutrition Research Center at Baylor College of Medicine · US

Funding

Project 3: Coactivator-dependent hepatic 12h clock coordinates metabolic and stress rhythmsP01DK113954 · NIDDK · BAYLOR COLLEGE OF MEDICINE · PI O'MALLEY, BERT W · 2018 to 2022
$7.9M
Hypothalamic Grb10 and body weightR01DK115761 · NIDDK · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI FRAZER, ALAN, XU, YONG · 2018 to 2021
$2.0M
Neurobiology for the sex differences in energy balanceR01DK117281 · NIDDK · BAYLOR COLLEGE OF MEDICINE · PI XU, YONG · 2018 to 2022
$1.8M
Targeting hypothalamic steroid receptor co-activator-1 to treat obesityR01DK101379 · NIDDK · BAYLOR COLLEGE OF MEDICINE · PI XU, YONG · 2014 to 2017
$1.2M
NIDDK NIH HHS P01 DK113954NIDDK NIH HHS R01 DK101379NIDDK NIH HHS R01 DK115761NIDDK NIH HHS R01 DK117281
6 · The paper itself

Abstract

Sex differences exist in the regulation of energy homeostasis. Better understanding of the underlying mechanisms for sexual dimorphism in energy balance may facilitate development of gender-specific therapies for human diseases, e.g. obesity. Multiple organs, including the brain, liver, fat and muscle, play important roles in the regulations of feeding behavior, energy expenditure and physical activity, which therefore contribute to the maintenance of energy balance. It has been increasingly appreciated that this multi-organ system is under different regulations in male vs. female animals. Much of effort has been focused on roles of sex hormones (including androgens, estrogens and progesterone) and sex chromosomes in this sex-specific regulation of energy balance. Emerging evidence also indicates that other factors (not sex hormones/receptors and not encoded by the sex chromosomes) exist to regulate energy homeostasis differentially in males vs. females. In this review, we summarize factors and signals that have been shown to regulate energy homeostasis in a sexually dimorphic fashion and propose a framework where these factors and signals may be integrated to mediate sex differences in energy homeostasis.

Indexed as

Energy MetabolismHomeostasisSex CharacteristicsBody WeightFemaleGonadal Steroid HormonesHumansMaleSex ChromosomesGonadal Steroid Hormones

Identifiers

PMID31130779
PMCPMC6528488
OpenAlexW2903778427

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.