Evidence map›Paper›PMID 31130604›Full record

ReviewNutrients2019

Dietary Flaxseed as a Strategy for Improving Human Health.

Mihir Parikh, Thane G Maddaford, J Alejandro Austria, Michel Aliani, Thomas Netticadan, Grant N Pierce

Open access · goldAbstract readReview
In one paragraph

Review in Nutrients, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 100 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
100citing papers in PubMed, 1 pooled it
18.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

100 citing papers in PubMed, 1 synthesis or guideline pooled it, 260 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Trial
  4. Trial
  5. Phytochemicals with potential NMDAR-inhibitory activities: a review of neuroprotective mechanisms against excitotoxicity.Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society · 2026
    Review
  6. Review
  7. Review
  8. Identification, Bioinformatics, and Expression Analysis ofInternational journal of molecular sciences · 2026
    Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Review
  16. Article
  17. Article
  18. Article
  19. Review
  20. A Comparative Assessment of Flaxseed (Food science & nutrition · 2025
    Article

40 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Mihir ParikhDepartment of Physiology and Pathophysiology, College of Medicine, Faculty of Health Sciences, University of Manitoba, Winnipeg, MB R3E 0W3, Canada. mparikh@sbrc.ca.
Thane G MaddafordDepartment of Physiology and Pathophysiology, College of Medicine, Faculty of Health Sciences, University of Manitoba, Winnipeg, MB R3E 0W3, Canada. tmaddaford@sbrc.ca.
J Alejandro AustriaDepartment of Physiology and Pathophysiology, College of Medicine, Faculty of Health Sciences, University of Manitoba, Winnipeg, MB R3E 0W3, Canada. aaustria@sbrc.ca.
Michel AlianiCanadian Centre for Agri-Food Research in Health and Medicine (CCARM), Albrechtsen Research Centre, St Boniface Hospital, 351 Taché Avenue, Winnipeg, MB R2H 2A6, Canada. maliani@sbrc.ca.
Thomas NetticadanDepartment of Physiology and Pathophysiology, College of Medicine, Faculty of Health Sciences, University of Manitoba, Winnipeg, MB R3E 0W3, Canada. tnetticadan@sbrc.ca.
Grant N PierceDepartment of Physiology and Pathophysiology, College of Medicine, Faculty of Health Sciences, University of Manitoba, Winnipeg, MB R3E 0W3, Canada. gpierce@sbrc.ca.
St. Boniface Hospital · CAUniversity of Manitoba · CA

Funding

Canadian Institutes of Health Research FoundationThis work was supported by CIHR, Western Grain Research Foundation, Saskflax, ARDI and St Boniface Hospital Foundation. None
6 · The paper itself

Abstract

Flaxseed is a rich source of the omega-3 fatty acid, alpha linolenic acid, the lignan secoisolariciresinol diglucoside and fiber. These compounds provide bioactivity of value to the health of animals and humans through their anti-inflammatory action, anti-oxidative capacity and lipid modulating properties. The characteristics of ingesting flaxseed or its bioactive components are discussed in this article. The benefits of administering flaxseed or the individual bioactive components on health and disease are also discussed in this review. Specifically, the current evidence on the benefits or limitations of dietary flaxseed in a variety of cardiovascular diseases, cancer, gastro-intestinal health and brain development and function, as well as hormonal status in menopausal women, are comprehensive topics for discussion.

Indexed as

Dietalpha-Linolenic AcidAnimalsAnti-Inflammatory AgentsAntioxidantsBrainButylene GlycolsCardiovascular DiseasesDietary FiberDietary SupplementsFatty Acids, Omega-3FemaleFlaxFunctional FoodGastrointestinal DiseasesGlucosidesalpha-Linolenic AcidAnti-Inflammatory AgentsAntioxidantsButylene GlycolsDietary FiberFatty Acids, Omega-3GlucosidesHormonesLignanssecoisolariciresinol diglucosidecancercardiovasculardiabetesflaxseedfunctional foodmenopausemicrobiomenutraceutical

Identifiers

PMID31130604
PMCPMC6567199
OpenAlexW2945878060

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.