Evidence map›Paper›PMID 31130560›Full record

ArticleJournal of epidemiology2020

Proteinuria and Reduced Estimated Glomerular Filtration Rate are Independently Associated With Lower Cognitive Abilities in Apparently Healthy Community-Dwelling Elderly Men in Japan: A Cross-sectional Study.

Akira Fujiyoshi, Katsuyuki Miura, Takayoshi Ohkubo, Naoko Miyagawa, Yoshino Saito, Itsuko Miyazawa, Akihiko Shiino, Aya Kadota, Sayaka Kadowaki, Takashi Hisamatsu and 4 more

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PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of epidemiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.8field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 12 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 2 institutions in 1 country.

Akira FujiyoshiDepartment of Hygiene, Wakayama Medical School.ORCID http://orcid.org/0000-0002-5790-7119
Katsuyuki MiuraDepartment of Public Health, Shiga University of Medical Science.ORCID http://orcid.org/0000-0002-2646-9582
Takayoshi OhkuboDepartment of Hygiene and Public Health, Teikyo University School of Medicine.ORCID http://orcid.org/0000-0002-3283-8196
Naoko MiyagawaDepartment of Public Health, Shiga University of Medical Science.ORCID http://orcid.org/0000-0002-9148-1078
Yoshino SaitoDepartment of Public Health, Shiga University of Medical Science.
Itsuko MiyazawaDepartment of Medicine, Shiga University of Medical Science.
Akihiko ShiinoMolecular Neuroscience Research Center, Shiga University of Medical Science.
Aya KadotaDepartment of Public Health, Shiga University of Medical Science.ORCID http://orcid.org/0000-0001-7378-0544
Sayaka KadowakiDepartment of Public Health, Shiga University of Medical Science.
Takashi HisamatsuDepartment of Public Health, Shiga University of Medical Science.
Sayuki ToriiDepartment of Public Health, Shiga University of Medical Science.
Naoyuki TakashimaDepartment of Public Health, Shiga University of Medical Science.
Ikuo TooyamaMolecular Neuroscience Research Center, Shiga University of Medical Science.
Hirotsugu UeshimaDepartment of Public Health, Shiga University of Medical Science.ORCID http://orcid.org/0000-0002-7742-4253
Shiga University of Medical Science · JPTeikyo University · JP

Funding

Foreign CohortR01HL068200 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI SEKIKAWA, AKIRA · 2003 to 2012
$5.6M
NHLBI NIH HHS R01 HL068200
6 · The paper itself

Abstract

backgroundThe association of proteinuria and reduced estimated glomerular filtration rate (eGFR) with cognition needs more clarification. We cross-sectionally examined whether proteinuria and reduced eGFR, even in moderate stages, were independently associated with lower cognition in a community-based sample of elderly men.

methodsOur cohort initially comprised 1,094 men aged 40-79 years from a random sample from Shiga, Japan in 2006-2008. Of 853 men who returned for the follow-up examination (2009-2014), we analyzed 561 who were ≥65 years, free of stroke, and completed the Cognitive Abilities Screening Instrument (CASI) at follow-up (higher CASI scores [range 0 to 100] indicate better cognition). Proteinuria was assessed via dipstick. eGFR was calculated according to the Chronic Kidney Disease Epidemiology Collaboration Equation. Participants were divided into three groups either by eGFR (≥60, 59-40, and <40 mL/min/1.73 m

resultsSignificant trends of lower cognition were observed across the groups of worse proteinuria and lower eGFR independently: multivariable-adjusted mean CASI scores were 90.1, 89.3, and 88.4 for proteinuria (P

conclusionsProteinuria and reduced eGFR, even in their moderate stages, were independently associated with lower cognition in a community-based sample of elderly men. The results suggest the importance of proteinuria and low eGFR for early detection and prevention of cognitive decline.

Indexed as

AgedCognitionCognitive DysfunctionCohort StudiesCross-Sectional StudiesGlomerular Filtration RateHumansIndependent LivingJapanMaleProteinuriaRisk Factorschronic kidney disease (CKD)cognitive functionestimated glomerular filtration rateproteinuria

Identifiers

PMID31130560
PMCPMC7217691
OpenAlexW2945655437

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.