ArticleCell stem cell2019
Human Hippocampal Neurogenesis Persists in Aged Adults and Alzheimer's Disease Patients.
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Article in Cell stem cell, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 364 papers, 1 of them a synthesis that pooled it.
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364citing papers in PubMed, 1 pooled it
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Who cites it
364 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Hippocampal neurogenesis in adult primates: a systematic review.Molecular psychiatry · 2025Pooled it
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- Trial
- Article
- Unraveling the potential of gasotransmitters as neurogenic and neuroprotective molecules: focus on Alzheimer's and Parkinson's diseases.Redox report : communications in free radical research · 2026Review
- Silibinin Alleviates Cognitive Dysfunction, Biochemical Alterations, and Hippocampal Structural Changes Induced by 5 days of Sleep Deprivation with or Without a Subsequent 24-H Recovery in Rats.Molecular neurobiology · 2026Article
- The Adult Neurogenesis Theory of Alzheimer's Disease Predicts Where Tauopathy Develops in the Brain.International journal of molecular sciences · 2026Review
- Effects of a three-month exercise programme on cognition, mood and neurogenesis: the NeuroFit randomised controlled trial.npj aging · 2026Article
- Biomaterial gels drive endogenous neurogenesis to support functional recovery after adult traumatic cortical injury.Neural regeneration research · 2026Article
- Protocol for functional characterization of adult hippocampal neural precursor cells under demyelinating injury conditions in mice.STAR protocols · 2026Article
- Review
- Special Issue "Molecular Insight into Alzheimer's Disease".International journal of molecular sciences · 2026Article
- TNF-α induces type I IFN signalling to suppress neurogenesis and recruit T cells.Nature communications · 2026Article
- Temporal Interference Stimulation Enhances Neural Regeneration.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- BDNF-Hyaluronic Acid Hydrogel Promotes Neuronal Differentiation of Neural Stem Cells in Aβ-Induced Injury and 5×FAD Mice.Biomedicines · 2026Article
- Microglia regulate adult neurogenesis via interleukin-6Research square · 2026Article
- Heterogeneity of the adult mammalian forebrain neurogenic ependyma: A comprehensive cellular map.Neural regeneration research · 2026Article
- Investigating the Causal Links between the Aging Process and Alzheimer's Disease Pathogenesis.International journal of stem cells · 2026Review
- Humanised Environmental Enrichment: Spatial Effects of Cities and Buildings on Adult Hippocampal Neurogenesis in Humans.International journal of molecular sciences · 2026Review
- Therapeutic reactivation of hippocampal progenitors reverse cognition decline in mice with progressive brain demyelination.Stem cell reports · 2026Article
304 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
11 authors.
Matthew K TobinDepartment of Anatomy and Cell Biology, University of Illinois at Chicago, Chicago, IL, USA.
Kianna MusaracaDepartment of Anatomy and Cell Biology, University of Illinois at Chicago, Chicago, IL, USA.
Ahmed DisoukyDepartment of Anatomy and Cell Biology, University of Illinois at Chicago, Chicago, IL, USA.
Aashutosh ShettiDepartment of Anatomy and Cell Biology, University of Illinois at Chicago, Chicago, IL, USA.
Abdullah BheriDepartment of Anatomy and Cell Biology, University of Illinois at Chicago, Chicago, IL, USA.
William G HonerDepartment of Psychiatry, The University of British Columbia, Vancouver, BC, Canada.
Namhee KimRush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, USA; Department of Neurological Sciences, Rush University Medical Center, Chicago, IL, USA.
Robert J DaweRush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, USA; Department of Diagnostic Radiology, Rush University Medical Center, Chicago, IL, USA.
David A BennettRush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, USA; Department of Neurological Sciences, Rush University Medical Center, Chicago, IL, USA.
Konstantinos ArfanakisRush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, USA; Department of Diagnostic Radiology, Rush University Medical Center, Chicago, IL, USA; Department of Biomedical Engineering, Illinois Institute of Technology, Chicago, IL, USA.
Orly LazarovDepartment of Anatomy and Cell Biology, University of Illinois at Chicago, Chicago, IL, USA. Electronic address: olazarov@uic.edu.
Funding
Tumor Environment and Metastasis (TEAM) Research ProgramP30CA060553 · NCI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Daniela E Matei · 1993 to 2026
$153.9MSUPPLEMENT TO RUSH ALZHEIMERS DISEASE CENTER COREP30AG010161 · NIA · RUSH UNIVERSITY MEDICAL CENTER · PI BENNETT, DAVID ALAN · 1991 to 2020
$49.1MEPIDEMIOLOGY OF NEURAL RESERVE AND NEUROBIOLOGY IN AGINGR01AG017917 · NIA · RUSH UNIVERSITY MEDICAL CENTER · PI BENNETT, DAVID ALAN · 2001 to 2023
$43.3MCharacterizing the Behavior Profile of Healthy Cognitive AgingR01AG034374 · NIA · RUSH UNIVERSITY MEDICAL CENTER · PI PATRICIA A BOYLE · 2009 to 2026
$8.8MThe role of PS1 in regulation of adult neurogenesis in the intact and Alzheimer?sR01AG033570 · NIA · UNIVERSITY OF ILLINOIS AT CHICAGO · PI Orly Lazarov · 2009 to 2026
$5.6MPlasticity circuits in Alzheimer s diseaseRF1AG033570 · NIA · UNIVERSITY OF ILLINOIS AT CHICAGO · PI LAZAROV, ORLY · 2020 to 2021
$2.9MEpidemiologic Study of Neural Reserve and Neurobiology of AgingR56AG017917 · NIA · RUSH UNIVERSITY MEDICAL CENTER · PI DAVID ALAN BENNETT · 2026 to 2026
$2.6MMechanisms underlying sporadic Alzheimer's diseaseR01AG060238 · NIA · UNIVERSITY OF ILLINOIS AT CHICAGO · PI LAZAROV, ORLY · 2018 to 2022
$2.4MAcceleration of AD Phenotypes in Asymptomatic Mouse ModelsR01AG062251 · NIA · UNIVERSITY OF ILLINOIS AT CHICAGO · PI LAZAROV, ORLY · 2018 to 2022
$2.2MMultimodal MRI biomarkers of small vessel disease for older persons with and without dementia.UH2NS100599 · NINDS · RUSH UNIVERSITY MEDICAL CENTER · PI ARFANAKIS, KONSTANTINOS, SCHNEIDER, JULIE A. · 2016 to 2017
$2.2MSignaling pathways regulating hippocampal neurogenesis in the adult mouseR21AG061628 · NIA · UNIVERSITY OF ILLINOIS AT CHICAGO · PI LAZAROV, ORLY · 2019 to 2020
$440kNCI NIH HHS P30 CA060553NIA NIH HHS P30 AG010161NIA NIH HHS R01 AG017917NIA NIH HHS R01 AG033570NIA NIH HHS R01 AG034374NIA NIH HHS R01 AG060238NIA NIH HHS R01 AG062251NIA NIH HHS R21 AG061628NIA NIH HHS R56 AG017917NIA NIH HHS RF1 AG033570NINDS NIH HHS UH2 NS100599
Abstract
Whether hippocampal neurogenesis persists throughout life in the human brain is not fully resolved. Here, we demonstrate that hippocampal neurogenesis is persistent through the tenth decade of life and is detectable in patients with mild cognitive impairments and Alzheimer's disease. In a cohort of 18 participants with a mean age of 90.6 years, Nestin
Indexed as
Aged, 80 and overAgingAlzheimer DiseaseCells, CulturedCognitionCohort StudiesDoublecortin Domain ProteinsDoublecortin ProteinFemaleHippocampusHumansMaleMicrotubule-Associated ProteinsNestinNeural Stem CellsNeurogenesisDCX protein, humanDoublecortin Domain ProteinsDoublecortin ProteinMicrotubule-Associated ProteinsNestinNeuropeptidesPCNA protein, humanProliferating Cell Nuclear AntigenSNARE ProteinsSOX2 protein, humanSOXB1 Transcription Factorsadult neurogenesisagingAlzheimer’s diseasecognitive dysfunctionhuman neurogenesisneural stem cellsneurogenesis in aging
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.