ArticleCell stem cell2019
OLIG2 Drives Abnormal Neurodevelopmental Phenotypes in Human iPSC-Based Organoid and Chimeric Mouse Models of Down Syndrome.
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Article in Cell stem cell, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 119 papers, 2 of them syntheses that pooled it.
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119citing papers in PubMed, 2 pooled it
24.2field-weighted citation impact, top 1% of its field
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Who cites it
119 citing papers in PubMed, 2 syntheses or guidelines pooled it, 198 citations in OpenAlex.
- Mapping the Cerebral Organoid Landscape: A Systematic Review of Preclinical 3D Models in Neuroscience.Advanced healthcare materials · 2026Pooled it
- Meta-Analysis of Down Syndrome Cortical Development Reveals Underdeveloped State of the Science.Frontiers in cellular neuroscience · 2022Pooled it
- A Researcher's guide to rodent models of Down syndrome: Recent insights and translational perspectives.STAR protocols · 2026Review
- Patient-derived tau-seeded human neuronal chimeras recapitulate mature Alzheimer's tau pathology and uncover human-specific neuronal vulnerability.bioRxiv : the preprint server for biology · 2026Article
- Advances and applications of brain organoids in central nervous system disorders: Bridging the gap from laboratory to clinic.Neural regeneration research · 2026Article
- Modeling Prenatal Immune Activation in Human Brain Organoids Uncovers IL-6-Dependent Interneuron Dysmaturation.bioRxiv : the preprint server for biology · 2026Article
- REST deficiency and neurogenic-to-gliogenic shift in down syndrome human cerebral organoids.Molecular brain · 2026Article
- Selective chr21 homolog silencing reveals polymorphisms influence the epigenetic silencing and functional dosage of RWDD2B.American journal of human genetics · 2026Article
- Ethanol induces neuroimmune dysregulation and soluble TREM2 generation in a human iPSC neuron, astrocyte, microglia triculture model.Alcohol (Fayetteville, N.Y.) · 2026Article
- Mechanosensor YAP orchestrates human neural rosette morphogenesis via TEAD4-LEF1 transcriptional nexus.Science China. Life sciences · 2026Article
- Chimeric brain models to study human glial-neuronal and macroglial-microglial interactions.Cell reports · 2026Article
- Integrative transcriptome-wide association analyses reveal PRKCG-linked GABAergic dysfunction in Fragile X-associated tremor/ataxia syndrome.Nature communications · 2026Article
- A myeloid trisomy 21-associated gene variant is protective from Alzheimer's disease.Nature neuroscience · 2026Article
- Pluripotent stem cells-based neural organoids for modelling human brain development and diseases.Cell & bioscience · 2025Review
- Telomere Biology, Erosion, and Age-Related Conditions: Insights from Down Syndrome and Other Telomere-Associated Disorders.Molecular neurobiology · 2025Review
- Selective chr21 homolog silencing reveals polymorphisms influence the epigenetic silencing and functional dosage of RWDD2B.bioRxiv : the preprint server for biology · 2025Article
- Organoids in Genetic Disorders: from Disease Modeling to Translational Applications.Stem cell reviews and reports · 2025Review
- Alzheimer's disease patient brain extracts induce multiple pathologies in novel vascularized neuroimmune organoids for disease modeling and drug discovery.Molecular psychiatry · 2025Article
- Accelerated Tempo of Cortical Neurogenesis in Down Syndrome.bioRxiv : the preprint server for biology · 2025Article
- Towards a quality control framework for cerebral cortical organoids.Scientific reports · 2025Article
59 more citing papers are in PubMed but not listed here.
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Authors and funding
11 authors at 4 institutions in 1 country.
Ranjie XuDepartment of Cell Biology and Neuroscience, Rutgers University, Piscataway, NJ 08854, USA; Department of Developmental Neuroscience, Munroe-Meyer Institute and Mary & Dick Holland Regenerative Medicine Program, University of Nebraska Medical Center, Omaha, NE 68198, USA.
Andrew T BrawnerDepartment of Developmental Neuroscience, Munroe-Meyer Institute and Mary & Dick Holland Regenerative Medicine Program, University of Nebraska Medical Center, Omaha, NE 68198, USA.
Shenglan LiDepartment of Neurosurgery and Center for Stem Cell and Regenerative Medicine, University of Texas Health Science Center at Houston, Houston, TX 77030, USA.
Jing-Jing LiuDepartment of Neuroscience and Cell Biology and Child Health Institute of New Jersey, Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ 08901, USA.
Hyosung KimDepartment of Cell Biology and Neuroscience, Rutgers University, Piscataway, NJ 08854, USA.
Haipeng XueDepartment of Neurosurgery and Center for Stem Cell and Regenerative Medicine, University of Texas Health Science Center at Houston, Houston, TX 77030, USA.
Zhiping P PangDepartment of Neuroscience and Cell Biology and Child Health Institute of New Jersey, Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ 08901, USA.
Woo-Yang KimDepartment of Biological Sciences, Kent State University, Kent, OH 44242, USA.
Ronald P HartDepartment of Cell Biology and Neuroscience, Rutgers University, Piscataway, NJ 08854, USA.
Ying LiuDepartment of Neurosurgery and Center for Stem Cell and Regenerative Medicine, University of Texas Health Science Center at Houston, Houston, TX 77030, USA.
Peng JiangDepartment of Cell Biology and Neuroscience, Rutgers University, Piscataway, NJ 08854, USA; Department of Developmental Neuroscience, Munroe-Meyer Institute and Mary & Dick Holland Regenerative Medicine Program, University of Nebraska Medical Center, Omaha, NE 68198, USA. Electronic address: peng.jiang@rutgers.edu.
Rutgers, The State University of New Jersey · USThe University of Texas Health Science Center at Houston · USKent State University · USNebraska Medical Center · US
Funding
UNMC Histology/Imaging and Creighton University Imaging Core FacilityP30GM110768 · NIGMS · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI WALSH, EDWARD J · 2014 to 2018
$5.1MDeciphering the neural basis of alcohol use disorders using human and mouse neuronsR01AA023797 · NIAAA · RUTGERS BIOMEDICAL AND HEALTH SCIENCES · PI ZHIPING P. PANG · 2016 to 2026
$4.8MEpigenetic mechanisms of indole-3-carbinol/diindolylemthane and triterpenoids in prevention of prostate inflammation and related diseaseR01AT009152 · NCCIH · RUTGERS, THE STATE UNIV OF N.J. · PI KONG, AH-NG TONY · 2015 to 2019
$3.3MMechanism of Gene Environment Interactions in Alzheimer's DiseaseR01ES026057 · NIEHS · NORTHEAST OHIO MEDICAL UNIVERSITY · PI RICHARDSON, JASON R · 2016 to 2020
$2.4MReconnecting the injured cervical spinal cord by transplanted human iPSC-derived neural progenitorsR01NS110707 · NINDS · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI LIU, YING · 2019 to 2023
$1.7MNovel Functions of OLIG2 in Regulating Human Interneuron Production in Health and DiseaseR01NS102382 · NINDS · RUTGERS, THE STATE UNIV OF N.J. · PI JIANG, PENG · 2018 to 2022
$1.6MPost-transcriptional gene regulation in normal and diseased neuronsR21NS097992 · NINDS · RBHS-NEW JERSEY MEDICAL SCHOOL · PI PANG, ZHIPING P., TIAN, BIN · 2017 to 2018
$437kDeveloping an Astroglial Model for Down SyndromeR21HD091512 · NICHD · RUTGERS, THE STATE UNIV OF N.J. · PI JIANG, PENG · 2017 to 2018
$426kHigh throughput multicompartment culture chambers to develop neurocircuit models of addiction riskR21DA039686 · NIDA · RUTGERS, THE STATE UNIV OF N.J. · PI HART, RONALD P, PANG, ZHIPING P. · 2015 to 2016
$382kNCCIH NIH HHS R01 AT009152NIAAA NIH HHS R01 AA023797NICHD NIH HHS R21 HD091512NIDA NIH HHS R21 DA039686NIEHS NIH HHS R01 ES026057NIGMS NIH HHS P30 GM110768NINDS NIH HHS R01 NS102382NINDS NIH HHS R01 NS110707NINDS NIH HHS R21 NS097992
Abstract
Down syndrome (DS) is a common neurodevelopmental disorder, and cognitive defects in DS patients may arise from imbalances in excitatory and inhibitory neurotransmission. Understanding the mechanisms underlying such imbalances may provide opportunities for therapeutic intervention. Here, we show that human induced pluripotent stem cells (hiPSCs) derived from DS patients overproduce OLIG2
Indexed as
AnimalsCell DifferentiationCell LineageCells, CulturedDisease Models, AnimalDown SyndromeHumansInduced Pluripotent Stem CellsInterneuronsMiceMice, Inbred C57BLNeural Stem CellsNeurodevelopmental DisordersNeurogenesisOligodendrocyte Transcription Factor 2OrganoidsOLIG2 protein, humanOligodendrocyte Transcription Factor 2RNA, Small Interferingbrain organoidchimeric mouse brainDown syndromehuman induced pluripotent stem cellinterneuronneurodevelopmental disorderOLIG1OLIG2
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