Evidence map›Paper›PMID 31130466›Full record

ArticleCell metabolism2019

Nutrient Sensing in CD11c Cells Alters the Gut Microbiota to Regulate Food Intake and Body Mass.

D Nyasha Chagwedera, Qi Yan Ang, Jordan E Bisanz, Yew Ann Leong, Kirthana Ganeshan, Jingwei Cai, Andrew D Patterson, Peter J Turnbaugh, Ajay Chawla

Open access · bronzeAbstract read
In one paragraph

Article in Cell metabolism, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 37 citations in OpenAlex.

  1. Trial
  2. Review
  3. Animal nutrition (Zhongguo xu mu shou yi xue hui) · 2025
    Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Frontiers in microbiomes · 2023
    Review
  11. Chronic Inflammation in Obesity and Cancer Cachexia.Journal of clinical medicine · 2022
    Review
  12. Review
  13. Article
  14. Review
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Hesperidin: A Therapeutic Agent For Obesity.Drug design, development and therapy · 2019
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 2 countries.

D Nyasha ChagwederaCardiovascular Research Institute, University of California, San Francisco, San Francisco, CA 94143-0795, USA.
Qi Yan AngDepartment of Microbiology & Immunology, University of California, San Francisco (UCSF), San Francisco, CA 94143, USA.
Jordan E BisanzDepartment of Microbiology & Immunology, University of California, San Francisco (UCSF), San Francisco, CA 94143, USA.
Yew Ann LeongCardiovascular Research Institute, University of California, San Francisco, San Francisco, CA 94143-0795, USA; Centre for Inflammatory Diseases, Department of Medicine, School of Clinical Sciences at Monash Health, Monash University, Melbourne, VIC, Australia.
Kirthana GaneshanCardiovascular Research Institute, University of California, San Francisco, San Francisco, CA 94143-0795, USA.
Jingwei CaiCenter for Molecular Toxicology and Carcinogenesis, Department of Veterinary and Biomedical Sciences, The Pennsylvania State University, University Park, PA 16802, USA.
Andrew D PattersonCenter for Molecular Toxicology and Carcinogenesis, Department of Veterinary and Biomedical Sciences, The Pennsylvania State University, University Park, PA 16802, USA.
Peter J TurnbaughDepartment of Microbiology & Immunology, University of California, San Francisco (UCSF), San Francisco, CA 94143, USA.
Ajay ChawlaCardiovascular Research Institute, University of California, San Francisco, San Francisco, CA 94143-0795, USA; Departments of Physiology and Medicine, University of California, San Francisco, San Francisco, CA 94143-0795, USA. Electronic address: ajay.chawla@ucsf.edu.
University of California, San Francisco · USPennsylvania State University · US

Funding

MEDICAL SCIENTIST TRAINING PROGRAMT32GM007618 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI ANDERSON, MARK S · 1985 to 2020
$29.6M
Predicting and preventing drug metabolism by the human gut microbiomeR01HL122593 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Peter James Turnbaugh · 2016 to 2026
$5.7M
Innate Immune Mechanisms of ThermogenesisR01DK094641 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI WANG, BIAO · 2011 to 2019
$3.5M
Transcriptional control in brown and beige adipocytesR01DK105175 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI WANG, BIAO · 2015 to 2019
$1.8M
Myeloid Cell Functions in Obesity and Diabetes.R01DK101064 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CHAWLA, AJAY · 2015 to 2018
$1.6M
Regulation of Systemic Metabolism by Immune Cell Nutrient Sensing PathwaysF31DK112669 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CHAGWEDERA, DANAI NYASHA · 2017 to 2020
$136k
NHLBI NIH HHS R01 HL122593NIDDK NIH HHS F31 DK112669NIDDK NIH HHS R01 DK094641NIDDK NIH HHS R01 DK101064NIDDK NIH HHS R01 DK105175NIGMS NIH HHS T32 GM007618
6 · The paper itself

Abstract

Microbial dysbiosis and inflammation are implicated in diet-induced obesity and insulin resistance. However, it is not known whether crosstalk between immunity and microbiota also regulates metabolic homeostasis in healthy animals. Here, we report that genetic deletion of tuberous sclerosis 1 (Tsc1) in CD11c

Indexed as

AnimalsBody WeightCD11 AntigensEatingGastrointestinal MicrobiomeMiceMice, Inbred C57BLMice, TransgenicNutrientsTuberous Sclerosis Complex 1 ProteinCD11 AntigensItgax protein, mouseNutrientsTsc1 protein, mouseTuberous Sclerosis Complex 1 Proteincohousingcomparative genomicscoprophagiaenergy balanceIgAimmunometabolisminnate immunityLactobacillusphylogenetics

Identifiers

PMID31130466
PMCPMC6687538
OpenAlexW2945977831

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.