ArticleCell metabolism2019
Polyamines and eIF5A Hypusination Modulate Mitochondrial Respiration and Macrophage Activation.
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Article in Cell metabolism, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 246 papers.
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246citing papers in PubMed
14.3field-weighted citation impact, top 1% of its field
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Who cites it
246 citing papers in PubMed, 389 citations in OpenAlex.
- Spermidine Mitigates Immune Cell Senescence and Boosts Vaccine Responses in Healthy Older Adults-A Pilot Study.Aging cell · 2026Trial
- Lubiprostone in chronic kidney disease: Insights into mitochondrial function and polyamines from a randomized phase 2 clinical trial.Science advances · 2025Trial
- Coenzyme A activates TLR4 and enhances alternative macrophage activation in line with MyD88 agonism.EMBO reports · 2026Article
- α-Ketoglutarate accelerates cutaneous wound healing through modulating the epithelial-fibroblast niche.JCI insight · 2026Article
- IL-9R/Arg1 pathway promotes polyamine metabolism in human airway macrophages.The Journal of allergy and clinical immunology · 2026Article
- Polyamine metabolism in ischemia reperfusion injury: common mitochondrial mechanisms and organ-specific differences.Journal of translational medicine · 2026Review
- TAdvanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- The microenvironment dictates glyco-immune surveillance via HSF1-mediated metabolism.Science advances · 2026Article
- Tumor evolution: signaling pathways, molecular mechanisms and therapeutic targets.Signal transduction and targeted therapy · 2026Review
- Butyrate epigenetically licenses sustained epithelial-T cell crosstalk for intestinal immune tolerance.Nature communications · 2026Article
- Polyamines in CNS malignancies: positively charged culprits in the hijacking of neural and immune signaling pathways.Amino acids · 2026Review
- Comprehensive Lipidomic Profiling Reveals Distinct Metabolic Remodeling during Differentiation of Human Monocyte-Derived Macrophages.Journal of proteome research · 2026Article
- Co-translational protein targeting to mitochondria in the context of co-translational protein maturation.Protein science : a publication of the Protein Society · 2026Review
- AOC1 regulates labor initiation through spermidine-induced autophagy of placental trophoblast cells via EIF5A hypusination.Nature communications · 2026Article
- Multiomic analysis reveals that polyamines alter G. vaginalis-induced cervicovaginal epithelial cell dysfunction.Research square · 2026Article
- The competition of amino acid among tumors, tumor-associated macrophages and T cells based on metabolic reprogramming.iScience · 2026Review
- Spermidine-functionalized Janus hydrogel microneedles inhibit ferroptosis and promote healing of oral ulcers.Bioactive materials · 2026Article
- Metabolites as signalling molecules in the tumour immune microenvironment.Nature reviews. Immunology · 2026Review
- Arginase-1 Expressing Macrophages Interact with Myofibroblasts to Regulate Insulin-Like Growth Factor-1-Dependent Tubule Repair.Kidney360 · 2026Article
- Mitochondria serve as a holdout compartment for aggregation-prone proteins hindering efficient degradation.Nature communications · 2026Article
186 more citing papers are in PubMed but not listed here.
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Authors and funding
37 authors at 6 institutions in 4 countries.
Daniel J PulestonMax Planck Institute of Immunobiology and Epigenetics, Freiburg 79108, Germany; The Kennedy Institute of Rheumatology, University of Oxford, Oxford OX3 7FY, UK.
Michael D BuckMax Planck Institute of Immunobiology and Epigenetics, Freiburg 79108, Germany.
Ramon I Klein GeltinkMax Planck Institute of Immunobiology and Epigenetics, Freiburg 79108, Germany.
Ryan L KyleMax Planck Institute of Immunobiology and Epigenetics, Freiburg 79108, Germany.
George CaputaMax Planck Institute of Immunobiology and Epigenetics, Freiburg 79108, Germany.
David O'SullivanMax Planck Institute of Immunobiology and Epigenetics, Freiburg 79108, Germany.
Alanna M CameronMax Planck Institute of Immunobiology and Epigenetics, Freiburg 79108, Germany.
Angela CastoldiMax Planck Institute of Immunobiology and Epigenetics, Freiburg 79108, Germany.
Yaarub MusaMax Planck Institute of Immunobiology and Epigenetics, Freiburg 79108, Germany.
Agnieszka M KabatMax Planck Institute of Immunobiology and Epigenetics, Freiburg 79108, Germany.
Ying ZhangInstitute of Biochemistry and Molecular Biology, ZBMZ, Faculty of Medicine, and BIOSS Centre for Biological Signaling Studies, University of Freiburg, Freiburg 79104, Germany.
Lea J FlachsmannMax Planck Institute of Immunobiology and Epigenetics, Freiburg 79108, Germany.
Cameron S FieldMax Planck Institute of Immunobiology and Epigenetics, Freiburg 79108, Germany.
Annette E PattersonMax Planck Institute of Immunobiology and Epigenetics, Freiburg 79108, Germany.
Stefanie SchererDepartment of Animal Physiology and Immunology, Technical University of Munich, Freising, Germany.
Francesca AlfeiDepartment of Animal Physiology and Immunology, Technical University of Munich, Freising, Germany.
Francesc BaixauliMax Planck Institute of Immunobiology and Epigenetics, Freiburg 79108, Germany.
S Kyle AustinMax Planck Institute of Immunobiology and Epigenetics, Freiburg 79108, Germany.
Beth KellyMax Planck Institute of Immunobiology and Epigenetics, Freiburg 79108, Germany.
Mai MatsushitaMax Planck Institute of Immunobiology and Epigenetics, Freiburg 79108, Germany.
Jonathan D CurtisMax Planck Institute of Immunobiology and Epigenetics, Freiburg 79108, Germany.
Katarzyna M GrzesMax Planck Institute of Immunobiology and Epigenetics, Freiburg 79108, Germany.
Matteo VillaMax Planck Institute of Immunobiology and Epigenetics, Freiburg 79108, Germany.
Mauro CorradoMax Planck Institute of Immunobiology and Epigenetics, Freiburg 79108, Germany.
David E SaninMax Planck Institute of Immunobiology and Epigenetics, Freiburg 79108, Germany.
Jing QiuMax Planck Institute of Immunobiology and Epigenetics, Freiburg 79108, Germany.
Nora PällmanDivision of Haematology, University Hospital Zurich and University of Zurich, Zurich 8091, Switzerland.
Katelyn PazDepartment of Pediatrics, Division of Blood and Marrow Transplantation, University of Minnesota, Minneapolis, MN, USA.
Maria Elena MaccariInstitute for Immunodeficiency, Center for Chronic Immunodeficiency, Center for Pediatrics, and Faculty of Medicine, Medical Center - University of Freiburg, Freiburg 79106, Germany.
Bruce R BlazarDepartment of Pediatrics, Division of Blood and Marrow Transplantation, University of Minnesota, Minneapolis, MN, USA.
Gerhard MittlerMax Planck Institute of Immunobiology and Epigenetics, Freiburg 79108, Germany.
Joerg M BuescherMax Planck Institute of Immunobiology and Epigenetics, Freiburg 79108, Germany.
Dietmar ZehnDepartment of Animal Physiology and Immunology, Technical University of Munich, Freising, Germany.
Sabine RospertInstitute of Biochemistry and Molecular Biology, ZBMZ, Faculty of Medicine, and BIOSS Centre for Biological Signaling Studies, University of Freiburg, Freiburg 79104, Germany.
Edward J PearceMax Planck Institute of Immunobiology and Epigenetics, Freiburg 79108, Germany; Faculty of Biology, University of Freiburg, Freiburg 79104, Germany.
Stefan BalabanovDivision of Haematology, University Hospital Zurich and University of Zurich, Zurich 8091, Switzerland.
Erika L PearceMax Planck Institute of Immunobiology and Epigenetics, Freiburg 79108, Germany. Electronic address: pearce@ie-freiburg.mpg.de.
Max Planck Institute of Immunobiology and Epigenetics · DETechnical University of Munich · DEUniversity of Freiburg · DEUniversity Hospital of Zurich · CHUniversity of Minnesota · USUniversity of Oxford · GB
Funding
Enhancing Treg Therapeutic Efficacy in GVHDR01HL118979 · NHLBI · UNIVERSITY OF MINNESOTA · PI BLAZAR, BRUCE R, HIPPEN, KELI L · 2014 to 2025
$6.7MT-CELL TARGETING FOR GVHDR01HL056067 · NHLBI · UNIVERSITY OF MINNESOTA TWIN CITIES · PI BLAZAR, BRUCE R · 1995 to 2022
$5.4MDendritic Cell Function in SchistosomiasisR01AI053825 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI PEARCE, EDWARD J. · 2002 to 2010
$3.4MMACROPHAGE FATTY ACID METABOLISM IN IMMUNITY TO HELMINTHSR01AI110481 · NIAID · WASHINGTON UNIVERSITY · PI PEARCE, EDWARD J. · 2015 to 2019
$1.5MNHLBI NIH HHS R01 HL056067NHLBI NIH HHS R01 HL118979NIAID NIH HHS R01 AI053825NIAID NIH HHS R01 AI110481Wellcome Trust 201330/Z/16/Z
Abstract
How cells adapt metabolism to meet demands is an active area of interest across biology. Among a broad range of functions, the polyamine spermidine is needed to hypusinate the translation factor eukaryotic initiation factor 5A (eIF5A). We show here that hypusinated eIF5A (eIF5A
Indexed as
AnimalsCells, CulturedEukaryotic Translation Initiation Factor 5AMacrophage ActivationMacrophagesMiceMice, Inbred C57BLMice, TransgenicMitochondriaPeptide Initiation FactorsPolyaminesProteomicsRNA-Binding ProteinsEukaryotic Translation Initiation Factor 5APeptide Initiation FactorsPolyaminesRNA-Binding Proteinsdeoxyhypusine hydroxylasedeoxyhypusine synthaseeIF5Ahypusinationimmunometabolismmacrophage activationmetabolismpolyamines
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.