ArticleCell reports2019
Two Distinct E2F Transcriptional Modules Drive Cell Cycles and Differentiation.
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Article in Cell reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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0cells of the map it votes in
31citing papers in PubMed
4.1field-weighted citation impact, top 5% of its field
What it found
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Who cites it
31 citing papers in PubMed, 63 citations in OpenAlex.
- A chromatin-informed transcriptional regulatory framework to stratify patients and guide therapy selection in triple-negative breast cancer.Nature communications · 2026Article
- Integration of single-cell transcriptome of female early gonadal development in bovine, goats, and pigs.iScience · 2026Article
- Dual roles of two Tfdps in germline nuclear meiosis and somatic nuclear fragmentation during sexual reproduction in the unicellular organismMarine life science & technology · 2026Article
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- Large Yellow Croaker (International journal of molecular sciences · 2025Article
- A conserved switch to less catalytically active Polycomb repressive complexes in non-dividing cells.Cell reports · 2025Article
- A concise guide to fluorescent cell cycle reporters for live-cell imaging.Frontiers in cell and developmental biology · 2025Review
- Sepsis pathogenesis and outcome are shaped by the balance between the transcriptional states of systemic inflammation and antimicrobial response.Cell reports. Medicine · 2024Article
- Neuregulin1 Nuclear Signaling Influences Adult Neurogenesis and Regulates a Schizophrenia Susceptibility Gene Network within the Mouse Dentate Gyrus.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Transcriptional repression and enhancer decommissioning silence cell cycle genes in postmitotic tissues.G3 (Bethesda, Md.) · 2024Article
- YY2/BUB3 Axis promotes SAC Hyperactivation and Inhibits Colorectal Cancer Progression via Regulating Chromosomal Instability.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Transcriptional repression and enhancer decommissioning silence cell cycle genes in postmitotic tissues.bioRxiv : the preprint server for biology · 2024Article
- CDK4/6 inhibitors and the pRB-E2F1 axis suppress PVR and PD-L1 expression in triple-negative breast cancer.Oncogenesis · 2023Article
- Transcription factor-driven coordination of cell cycle exit and lineage-specification in vivo during granulocytic differentiation : In memoriam Professor Niels Borregaard.Nature communications · 2022Article
- Single-cell chromatin profiling of the primitive gut tube reveals regulatory dynamics underlying lineage fate decisions.Nature communications · 2022Article
- Article
- Deep learning tools and modeling to estimate the temporal expression of cell cycle proteins from 2D still images.PLoS computational biology · 2022Article
- Understanding Retinoblastoma Post-Translational Regulation for the Design of Targeted Cancer Therapies.Cancers · 2022Review
- Immune Evasion and Drug Resistance Mediated by USP22 in Cancer: Novel Targets and Mechanisms.Frontiers in immunology · 2022Review
- Dynamic transcriptional reprogramming leads to immunotherapeutic vulnerabilities in myeloma.Nature cell biology · 2021Article
Corrections and comments
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Authors and funding
18 authors at 5 institutions in 1 country.
Maria C CuitiñoDepartment of Biochemistry and Molecular Biology, Hollings Cancer Center, Medical University of South Carolina, Charleston, SC 29425, USA.
Thierry PécotDepartment of Biochemistry and Molecular Biology, Hollings Cancer Center, Medical University of South Carolina, Charleston, SC 29425, USA.
Daokun SunDepartment of Biochemistry and Molecular Biology, Hollings Cancer Center, Medical University of South Carolina, Charleston, SC 29425, USA; Department of Molecular Genetics, Ohio State University, Columbus, OH 43210, USA.
Raleigh KladneyDepartment of Molecular Genetics, Ohio State University, Columbus, OH 43210, USA.
Takayuki Okano-UchidaDepartment of Biochemistry and Molecular Biology, Hollings Cancer Center, Medical University of South Carolina, Charleston, SC 29425, USA.
Neelam ShindeDepartment of Cancer Biology and Genetics, Ohio State University, Columbus, OH 43210, USA.
Resham SaeedDepartment of Cancer Biology and Genetics, Ohio State University, Columbus, OH 43210, USA.
Antonio J Perez-CastroDepartment of Cancer Biology and Genetics, Ohio State University, Columbus, OH 43210, USA.
Amy WebbComprehensive Cancer Center, Ohio State University, Columbus, OH 43210, USA.
Tom LiuComprehensive Cancer Center, Ohio State University, Columbus, OH 43210, USA.
Soo In BaeDepartment of Molecular Genetics, Ohio State University, Columbus, OH 43210, USA.
Linda ClijstersDepartment of Biochemistry and Molecular Pharmacology, Perlmutter Cancer Center, New York University School of Medicine, New York, NY 10016, USA.
Nicholas SelnerDepartment of Biochemistry and Molecular Biology, Hollings Cancer Center, Medical University of South Carolina, Charleston, SC 29425, USA.
Vincenzo CoppolaDepartment of Molecular Genetics, Ohio State University, Columbus, OH 43210, USA.
Cynthia TimmersDepartment of Biochemistry and Molecular Biology, Hollings Cancer Center, Medical University of South Carolina, Charleston, SC 29425, USA; Comprehensive Cancer Center, Ohio State University, Columbus, OH 43210, USA.
Michael C OstrowskiDepartment of Biochemistry and Molecular Biology, Hollings Cancer Center, Medical University of South Carolina, Charleston, SC 29425, USA.
Michele PaganoDepartment of Biochemistry and Molecular Pharmacology, Perlmutter Cancer Center, New York University School of Medicine, New York, NY 10016, USA; Howard Hughes Medical Institute, New York University School of Medicine, New York, NY 10016, USA.
Gustavo LeoneDepartment of Biochemistry and Molecular Biology, Hollings Cancer Center, Medical University of South Carolina, Charleston, SC 29425, USA. Electronic address: leoneg@musc.edu.
The Ohio State University · USMedical University of South Carolina · USHoward Hughes Medical Institute · USMUSC Hollings Cancer Center · USNew York University · US
Funding
Translational Therapeutics Research Program (TT)P30CA016058 · NCI · OHIO STATE UNIVERSITY · PI Tasleem J Padamsee · 1985 to 2026
$132.3MTranslational Science Laboratory Shared ResourceP30CA138313 · NCI · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI RAYMOND N. DUBOIS · 2009 to 2026
$42.7MF-Box Proteins: Deregulated Cell Cycle Control and Proteolysis in CancerR01CA076584 · NCI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI PAGANO, MICHELE · 1998 to 2021
$4.5MTumor Suppressor Roles of E2F7 & E2F8 in Hepatocellular Carcinoma (HCC)R01CA121275 · NCI · OHIO STATE UNIVERSITY · PI LEONE, GUSTAVO WALTER · 2008 to 2018
$3.1MDecoding tumors to achieve better clinical outcomesR50CA211529 · NCI · OHIO STATE UNIVERSITY · PI TIMMERS, CYNTHIA · 2017 to 2019
$515kHoward Hughes Medical InstituteNCI NIH HHS P30 CA016058NCI NIH HHS P30 CA138313NCI NIH HHS R01 CA076584NCI NIH HHS R01 CA121275NCI NIH HHS R50 CA211529
Abstract
Orchestrating cell-cycle-dependent mRNA oscillations is critical to cell proliferation in multicellular organisms. Even though our understanding of cell-cycle-regulated transcription has improved significantly over the last three decades, the mechanisms remain untested in vivo. Unbiased transcriptomic profiling of G
Indexed as
Cell CycleCell DifferentiationGene Expression RegulationAnimalsCell Cycle ProteinsCell ProliferationCells, CulturedE2F3 Transcription FactorE2F4 Transcription FactorFemaleMaleMiceMice, KnockoutPromoter Regions, GeneticRepressor ProteinsTranscriptomeCell Cycle ProteinsE2f3 protein, mouseE2F3 Transcription FactorE2f4 protein, mouseE2F4 Transcription FactorE2F8 protein, mouseRepressor Proteinscell cycleconfocal microscopydeep learningE2FE2F-tagged knockin miceFUCCI mouse embryosimage analysisimmunostainingRNA-seqtranscription
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