Evidence map›Paper›PMID 31130399›Full record

ArticleSchizophrenia research2019

Relationship between MEG global dynamic functional network connectivity measures and symptoms in schizophrenia.

L Sanfratello, J M Houck, V D Calhoun

Abstract read
In one paragraph

Article in Schizophrenia research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Article
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  5. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

L SanfratelloThe Mind Research Network, USA. Electronic address: lsanfratello@mrn.org.
J M HouckThe Mind Research Network, USA; The University of New Mexico, USA.
V D CalhounThe Mind Research Network, USA; The University of New Mexico, USA.

Funding

Transcranial Direct Current Stimulation for Treatment of Auditory Verbal HalluciP20GM103472 · NIGMS · THE MIND RESEARCH NETWORK · PI SUI, JING · 2012 to 2017
$14.3M
Multivariate methods for identifying multitask/multimodal brain imaging biomarkersR01EB006841 · NIBIB · THE MIND RESEARCH NETWORK · PI VINCE D CALHOUN, Sergey Plis · 2007 to 2026
$9.8M
Male/Female differences in psychosis and mood disorders:Dynamic imaging-genomic models for characterizing and predicting psychosis and mood dR01MH118695 · NIMH · GEORGIA STATE UNIVERSITY · PI ADALI, TULAY, CALHOUN, VINCE D · 2019 to 2023
$3.8M
Unified multivariate data-driven solutions for static and dynamic brain connectivityR01EB020407 · NIBIB · THE MIND RESEARCH NETWORK · PI ADALI, TULAY, CALHOUN, VINCE D · 2015 to 2018
$2.7M
Imaging Brain Activity in Substance Use TreatmentK01AA021431 · NIAAA · UNIVERSITY OF NEW MEXICO · PI HOUCK, JON M. · 2013 to 2017
$837k
NIAAA NIH HHS K01 AA021431NIAAA NIH HHS L30 AA026181NIBIB NIH HHS R01 EB006841NIBIB NIH HHS R01 EB020407NIGMS NIH HHS P20 GM103472NIMH NIH HHS R01 MH118695
6 · The paper itself

Abstract

An investigation of differences in dynamic functional network connectivity (dFNC) of healthy controls (HC) versus that of schizophrenia patients (SP) was completed, using eyes-open resting state MEG data. The MEG analysis utilized a source-space activity estimate (MNE/dSPM) whose result was the input to a group spatial independent component analysis (ICA), on which the networks of our MEG dFNC analysis were based. We have previously reported that our MEG dFNC revealed that SP change between brain meta-states (repeating patterns of network correlations which are allowed to overlap in time) significantly more often and to states which are more different, relative to HC. Here, we extend our previous work to investigate the relationship between symptomology in SP and four meta-state metrics. We found a significant correlation between positive symptoms and the two meta-state metrics which showed significant differences between HC and SP. These two statistics quantified 1) how often individuals change state and 2) the total distance traveled within the state-space. We additionally found that a clustering of the meta-state metrics divides SP into groups which vary in symptomology. These results indicate specific relationships between symptomology and brain function for SP.

Indexed as

MagnetoencephalographySchizophrenic PsychologyAdultBrainFemaleHumansMaleMiddle AgedNeural PathwaysSchizophreniaYoung AdultFunctional connectivityMagnetoencephalographyResting stateSchizophrenia

Identifiers

PMID31130399
PMCPMC6661190

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.