ArticleCell2019
A Growth-Based Framework for Leaf Shape Development and Diversity.
Article in Cell, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 125 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
125 citing papers in PubMed, 2 syntheses or guidelines pooled it, 269 citations in OpenAlex.
- A multiscale growth atlas of Arabidopsis: linking cell dynamics to organ development.The New phytologist · 2026Pooled it
- Overview of molecular mechanisms of plant leaf development: a systematic review.Frontiers in plant science · 2023Pooled it
- Mechanisms of Phenotypic Evolution from Molecules to Organisms: Integrating Evolutionary Biochemistry and Evolutionary Developmental Biology.Annual review of ecology, evolution, and systematics · 2026Article
- Inferring cell division from cell shape.The Plant cell · 2026Article
- Progressive oxygenation of developing leaves directs morphogenesis.Science advances · 2026Article
- A two-step auxin-GA cross-talk regulates organ formation in tomato.Development (Cambridge, England) · 2026Article
- Sweet Potato Gene Clusters Control Anthocyanin Biosynthesis and Leaf Morphology.Plant biotechnology journal · 2026Article
- LMI1 and TCP4 homologs form a functional module to regulate lateral petal asymmetric bending in Delphinium anthriscifolium.The Plant journal : for cell and molecular biology · 2026Article
- Analysis of Cauline Leaf Development inBio-protocol · 2026Article
- Morphogenesis of moss leaf-like organs through variations in deeply shared developmental principles.Science advances · 2026Article
- Auxin and cytokinin regulate growth dynamics underlying carpel initiation in Arabidopsis.Journal of experimental botany · 2026Article
- Correlations between surface area and volume in cell size and growth in Arabidopsis thaliana.BMC plant biology · 2026Article
- Epidermal Cell Dynamics Regulates Rice Lamina Joint Morphogenesis and Leaf Angle Formation through OsZHD1 and OsZHD2 Regulation.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Mutual inhibition between EPFL2 and auxin extends the intervals of periodic leaf morphogenesis.Nature communications · 2025Article
- RsRCO and RsLMI1 co-regulate the formation of lobed leaf in radish (Raphanus sativus L.).TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2025Article
- Homeodomain transcription factor regulation of leaf serrations in Arabidopsis thaliana.Journal of experimental botany · 2025Article
- Fine mapping of the dominant female sterility gene and novel model of hybrid seed production in cabbage (Brassica oleracea L. var. capitata).TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2025Article
- Predictive modeling, pattern recognition, and spatiotemporal representations of plant growth in simulated and controlled environments: A comprehensive review.Plant phenomics (Washington, D.C.) · 2025Review
- Biosynthesis of very Long-chain fatty acids is required for Arabidopsis auxin-mediated embryonic and post-embryonic development.The Plant journal : for cell and molecular biology · 2025Article
- Biregionally differentiated growth generates sharp apex and concave joints in leaves.The Plant journal : for cell and molecular biology · 2025Article
65 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
16 authors at 2 institutions in 2 countries.
Funding
Abstract
How do genes modify cellular growth to create morphological diversity? We study this problem in two related plants with differently shaped leaves: Arabidopsis thaliana (simple leaf shape) and Cardamine hirsuta (complex shape with leaflets). We use live imaging, modeling, and genetics to deconstruct these organ-level differences into their cell-level constituents: growth amount, direction, and differentiation. We show that leaf shape depends on the interplay of two growth modes: a conserved organ-wide growth mode that reflects differentiation; and a local, directional mode that involves the patterning of growth foci along the leaf edge. Shape diversity results from the distinct effects of two homeobox genes on these growth modes: SHOOTMERISTEMLESS broadens organ-wide growth relative to edge-patterning, enabling leaflet emergence, while REDUCED COMPLEXITY inhibits growth locally around emerging leaflets, accentuating shape differences created by patterning. We demonstrate the predictivity of our findings by reconstructing key features of C. hirsuta leaf morphology in A. thaliana. VIDEO ABSTRACT.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.