Evidence map›Paper›PMID 31130313›Full record

ArticleBiologicals : journal of the International Association of Biological Standardization2019

Meeting report narcolepsy and pandemic influenza vaccination: What we know and what we need to know before the next pandemic? A report from the 2nd IABS meeting.

Kathryn Edwards, Germaine Hanquet, Steve Black, Emmanuel Mignot, Christopher Jankosky, Tom Shimabukuro, Elizabeth Miller, Hanna Nohynek, Pieter Neels

Open access · hybridAbstract read
In one paragraph

Article in Biologicals : journal of the International Association of Biological Standardization, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 21 citations in OpenAlex.

  1. Trial
  2. The immunopathogenesis of narcolepsy type 1.Nature reviews. Immunology · 2024
    Review
  3. Article
  4. Article
  5. Review
  6. Article
  7. Narcolepsy risk and COVID-19.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2020
    Article
  8. Article
  9. Review
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 8 institutions in 4 countries.

Kathryn EdwardsMedical Center North, Vanderbilt University School of Medicine, Nashville, TN, D7227, USA. Electronic address: Kathryn.edwards@vumc.org.
Germaine HanquetBrussels, and Antwerp University, Universiteitsplein 1, 2610, Antwerp, Belgium. Electronic address: ghanquet@skynet.be.
Steve BlackCincinnati Children's Hospital, Cincinnati, OH, USA.
Emmanuel MignotStanford Center for Sleep Sciences and Medicine, Stanford University, Palo Alto, CA, USA.
Christopher JankoskyOffice of Biostatistics and Epidemiology, Center for Biologics Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, MD, USA.
Tom ShimabukuroImmunization Safety Office, Centers for Disease Control and Prevention (CDC), 1600, Clifton Road, Atlanta, GA, USA. Electronic address: TShimabukuro@cdc.gov.
Elizabeth MillerPublic Health England, London, United Kingdom.
Hanna NohynekNational Institute for Health and Welfare THL Department of Health Security, Infectious Disease Control and Vaccinations Unit Helsinki, Finland.
Pieter NeelsIABS, Rue de la Vallée 3, 1204, Genève, Switzerland. Electronic address: pieter.neels@vaccine-vaccine.be.
Cincinnati Children's Hospital Medical Center · USFinnish Institute for Health and Welfare · FINational Center for Immunization and Respiratory Diseases · USPublic Health England · GBStanford University · USUnited States Food and Drug Administration · USUniversity of Antwerp · BEVanderbilt University Medical Center · US

Funding

Intramural CDC HHS CC999999
6 · The paper itself

Abstract

A group of scientific and public health experts and key stakeholders convened to discuss the state of knowledge on the relationship between adjuvanted monovalent inactivated 2009 influenza A H1N1 vaccines used during the 2009 influenza pandemic and narcolepsy. There was consensus that an increased risk of narcolepsy was consistently observed after Pandemrix (AS03-adjuvanted) vaccine, but similar associations following Arepanrix (AS03-adjuvanted) or Focetria (MF59-adjuvanted) vaccines were not observed. Whether the differences are due to vaccine composition or other factors such as the timing of large-scale vaccination programs relative to H1N1pdm09 wild-type virus circulation in different geographic regions is not clear. The limitations of retrospective observational methodologies could also be contributing to some of the differences across studies. More basic and epidemiologic research is needed to further elucidate the association between adjuvanted influenza vaccine and narcolepsy and its mechanism and to inform planning and preparation for vaccination programs in advance of the next influenza pandemic.

Indexed as

Influenza, HumanInfluenza VaccinesNarcolepsyPandemicsVaccinationBiological Science DisciplinesCongresses as TopicFemaleHumansInfluenza A Virus, H1N1 SubtypeMaleSocieties, ScientificInfluenza VaccinesAdjuvantsAntigen system 03 (AS03)H1N1pdm09 influenza vaccinesNarcolepsyPandemic influenzaPandemrix vaccine

Identifiers

PMID31130313
PMCPMC6668612
OpenAlexW2945756247

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.