ArticleSocial science & medicine (1982)2022
Plastic diagnostics: The remaking of disease and evidence in personalized medicine.
Article in Social science & medicine (1982), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Crossing paths: historical and philosophical perspectives on cancer and diabetes classifications.History and philosophy of the life sciences · 2026Article
- Federated autoencoder-based clinical decision framework with hybrid class balancing.Scientific reports · 2026Article
- Sorting out and navigating uncertainty in precision medicine.History and philosophy of the life sciences · 2026Article
- Precision prevention and the temporal disruption of evidence: the case of heart rate notifications from wearables.Medicine, health care, and philosophy · 2026Article
- Model organism futures in precision toxicology: tracking the emergence of a research repertoire.Biology & philosophy · 2026Article
- Identifying behavior regulatory leverage over mental disorders transcriptomic network hubs toward lifestyle-dependent psychiatric drugs repurposing.Human genomics · 2025Article
- Decision-making as discovery: Vetting clinical research in a leading precision oncology service.Sociology of health & illness · 2024Article
- The roots of (in)equity in precision medicine: gaps in the discourse.Personalized medicine · 2024Article
- What rare cancers have in common. The making of lists of (very) rare cancers and the coordination of medical work.Frontiers in sociology · 2023Article
- Approaches in Post-Experimental Science. The Case of Precision Medicine.Berichte zur Wissenschaftsgeschichte · 2022Article
- Multidisciplinary perspectives on the regulation of diagnostic technologies.Social science & medicine (1982) · 2022Article
- Let's Get Back to Normal? COVID-19 and the Logic of Cure.Frontiers in sociology · 2022Review
- The molecular vista: current perspectives on molecules and life in the twentieth century.History and philosophy of the life sciences · 2021Article
- 'You should see a doctor', said the robot: Reflections on a digital diagnostic device in a pandemic age.Scandinavian journal of public health · 2021Article
- Between diagnostic precision and rapid decision-making: Using institutional ethnography to explore diagnostic work in the context of Cancer Patient Pathways in Norway.Sociology of health & illness · 2021Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Politically authorized reports on personalized and precision medicine stress an urgent need for finer-grained disease categories and faster taxonomic revision, through integration of genomic and phenotypic data. Developing a data-driven taxonomy is, however, not as simple as it sounds. It is often assumed that an integrated data infrastructure is relatively easy to implement in countries that already have highly centralized and digitalized health care systems. Our analysis of initiatives associated with the Danish National Genome Center, recently launched to bring Denmark to the forefront of personalized medicine, tells a different story. Through a "meta-taxonomy" of taxonomic revisions, we discuss what a genomics-based disease taxonomy entails, epistemically as well as organizationally. Whereas policy reports promote a vision of seamless data integration and standardization, we highlight how the envisioned strategy imposes significant changes on the organization of health care systems. Our analysis shows how persistent tensions in medicine between variation and standardization, and between change and continuity, remain obstacles for the production as well as the evaluation of genomics-based taxonomies of difference. We identify inherent conflicts between the ideal of dynamic revision and existing regulatory functions of disease categories in, for example, the organization and management of health care systems. Moreover, we raise concerns about shifts in the regulatory regime of evidence standards, where clinical care increasingly becomes a vehicle for biomedical research.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.