Evidence map›Paper›PMID 31129958›Full record

ArticleJournal of proteome research2019

DecoyDeveloper: An On-Demand, De Novo Decoy Glycopeptide Generator.

Joshua T Shipman, Xiaomeng Su, David Hua, Heather Desaire

Abstract read
In one paragraph

Article in Journal of proteome research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Joshua T ShipmanDepartment of Chemistry , University of Kansas , Lawrence , Kansas 66045 , United States.
Xiaomeng SuDepartment of Chemistry , University of Kansas , Lawrence , Kansas 66045 , United States.
David HuaDepartment of Chemistry , University of Kansas , Lawrence , Kansas 66045 , United States.
Heather DesaireDepartment of Chemistry , University of Kansas , Lawrence , Kansas 66045 , United States.ORCID 0000-0002-2181-0112

Funding

PHARMACEUTICAL ASPECTS OF BIOTECHNOLOGY TRAININGT32GM008359 · NIGMS · UNIVERSITY OF KANSAS LAWRENCE · PI SIAHAAN, TERUNA J., VOLKIN, DAVID · 1989 to 2018
$5.0M
Mass Spectrometry Measurements for Complex PTMsR35GM130354 · NIGMS · UNIVERSITY OF KANSAS LAWRENCE · PI DESAIRE, HEATHER R · 2019 to 2023
$1.9M
Development of a rapid glycosylation profiling system using mass spectrometry datR01GM103547 · NIGMS · UNIVERSITY OF KANSAS LAWRENCE · PI DESAIRE, HEATHER R · 2012 to 2017
$1.8M
NIGMS NIH HHS R01 GM103547NIGMS NIH HHS R35 GM130354NIGMS NIH HHS T32 GM008359
6 · The paper itself

Abstract

Glycopeptide analysis is a growing field that is struggling to adopt effective, automated tools. Many creative workflows and software apps have emerged recently that offer promising capabilities for assigning glycopeptides to MS data in an automated fashion. The effectiveness of these tools is best measured and improved by determining how often they would select a glycopeptide decoy as a spectral match, instead of its correct assignment; yet generating the appropriate number and type of glycopeptide decoys can be challenging. To address this need, we have designed DecoyDeveloper, an on-demand decoy glycopeptide generator that can produce a high volume of decoys with low mass differences. DecoyDeveloper has a simple user interface and is capable of producing large sets of decoys containing complete, biologically relevant glycan and peptide sequences. We demonstrate the tool's efficiency by applying it to a set of 80 glycopeptide targets. This tool is freely available and can be found at http://glycopro.chem.ku.edu/J1.php .

Indexed as

SoftwareAnimalsGlycopeptidesHumansProteomicsScientific Experimental ErrorTandem Mass SpectrometryGlycopeptidesbioinformaticsdecoysfalse discovery rateglycopeptidesglycosylationN-linked glycanstandem mass spectrometry

Identifiers

PMID31129958
PMCPMC6768553

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.