Evidence map›Paper›PMID 31129919›Full record

ArticleLasers in surgery and medicine2019

Treatment of Café-Au-Lait Spots Using Q-Switched Alexandrite Laser: Analysis of Clinical Characteristics of 471 Children in Mainland China.

Bin Zhang, Yan Chu, Zigang Xu, Yujuan Sun, Li Li, Xiaofeng Han, Chen Wang, Li Wei, Yuanxiang Liu, Lin Ma

Open access · hybridAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Lasers in surgery and medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
0.8field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 14 citations in OpenAlex.

  1. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Bin ZhangDepartment of Dermatology, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, 100045, Beijing, China.
Yan ChuDepartment of Dermatology, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, 100045, Beijing, China.
Zigang XuDepartment of Dermatology, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, 100045, Beijing, China.
Yujuan SunDepartment of Dermatology, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, 100045, Beijing, China.
Li LiDepartment of Dermatology, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, 100045, Beijing, China.
Xiaofeng HanDepartment of Dermatology, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, 100045, Beijing, China.
Chen WangDepartment of Dermatology, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, 100045, Beijing, China.
Li WeiDepartment of Dermatology, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, 100045, Beijing, China.
Yuanxiang LiuDepartment of Dermatology, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, 100045, Beijing, China.
Lin MaDepartment of Dermatology, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, 100045, Beijing, China.
Beijing Children’s Hospital · CNCapital Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND AND

objectivesCafé-au-lait spots, also known as café-au-lait macules (CALMs), are a common pigmentary disorder. Although various laser modalities have been used to treat CALMs, the efficacy of laser treatment in children differs from that in adults. We investigated the efficacy, safety, and clinical factors of the treatment of CALMs using Q-switched alexandrite laser (755 nm) therapy in children.

methodsIn total, 471 children with CALMs underwent Q-switched alexandrite laser therapy at a treatment interval of 3-12 months. The safety and efficacy of the laser treatment were evaluated by reviewing clinical records and photographs before and after treatments.

resultsOf the 471 patients, 140 (29.72%) were cured completely, 124 (26.33%) showed substantial improvement, 110 (23.35%) showed improvement, and 97 (20.60%) showed no improvement after one to nine treatments. The overall treatment success rate was 79.41%, and the treatment efficacy was positively correlated with the number of laser treatments (rs = 0.26, P < 0.0001). Sex and the interval of laser treatments were also associated with significant differences in treatment outcomes (P < 0.05). No obvious adverse effects were observed. Multivariate logistic regression analysis showed that the number of treatments influenced the treatment efficacy (odds ratio, 2.130; 95% confidence interval, 1.561-2.908).

conclusionsQ-switched alexandrite laser (755 nm) therapy is safe and highly effective for CALMs in children, and the number of treatments affects the treatment efficacy. Lasers Surg. Med. © 2019 The Authors. Lasers in Surgery and Medicine Published by Wiley Periodicals, Inc.

Indexed as

EstheticsAdolescentAge FactorsCafe-au-Lait SpotsChildChild, PreschoolChinaCohort StudiesFemaleFollow-Up StudiesHumansInfantLasers, Solid-StateLogistic ModelsLow-Level Light TherapyMalecafé-au-lait spotchildrenQ-switched alexandrite laser

Identifiers

PMID31129919
PMCPMC6771696
OpenAlexW2945624071

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.