Evidence map›Paper›PMID 31129918›Full record

ArticleJournal of clinical laboratory analysis2019

Clinical significance of high-mobility group box-1 (HMGB1) in subjects with type 2 diabetes mellitus (T2DM) combined with chronic obstructive pulmonary disease (COPD).

Jiayi Huang, Tingting Zeng, Yongjian Tian, Yang Wu, Jianlin Yu, Zihuan Pei, Liming Tan

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of clinical laboratory analysis, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
2.1field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 18 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Jiayi HuangDepartment of Clinical Laboratory, the Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China.ORCID https://orcid.org/0000-0003-4223-6719
Tingting ZengDepartment of Clinical Laboratory, the Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China.ORCID https://orcid.org/0000-0001-9938-1656
Yongjian TianDepartment of Clinical Laboratory, the Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China.ORCID https://orcid.org/0000-0002-4943-9116
Yang WuDepartment of Clinical Laboratory, the Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China.
Jianlin YuDepartment of Clinical Laboratory, the Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China.
Zihuan PeiDepartment of Clinical Laboratory, the Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China.
Liming TanDepartment of Clinical Laboratory, the Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China.
Nanchang University · CN

Funding

National Nature Science Foundation of China 81760382Nature Science Foundation of Jiangxi Province 20171BAB205076
6 · The paper itself

Abstract

backgroundSimple method to predict type 2 diabetes mellitus (T2DM) combined with chronic obstructive pulmonary disease (COPD) is in great need clinically. This study aims to assess the clinical significance of high-mobility group box-1 (HMGB1) in predicting T2DM combined with COPD in Chinese patients with T2DM or COPD.

methodsSerum concentrations of glycated hemoglobin (HbA1C), fasting plasma glucose (FPG), fasting insulin (FINS), total cholesterol (TC), triglyceride (TG), low-density lipoprotein cholesterol (LDL-c), high-density lipoprotein cholesterol (HDL-c), C-reactive protein (CRP), fibrinogen (FIB), HMGB1, white blood cell count (WBC), neutrophil% (NEU%), and lung function text such as forced expiratory volume 1/forced vital capacity (FEV1/FVC) and forced expiratory volume 1% predicted value (FEV1%pred) were measured in 126 T2DM patients, 118 COPD patients, 112 T2DM combined with COPD patients, and 120 healthy controls. Logistic regression was used to estimate the risk factors for T2DM combined with COPD.

resultsHigh-mobility group box-1 elevated in patients with T2DM combined with COPD, significantly higher than other subjects (P < 0.05), and differences in HMGB1 also existed between patients with T2DM or COPD and healthy individuals (P < 0.01). HMGB1 was positively correlated with HOMA-IR, FBG, and HbA1c (P < 0.01) and negatively correlated with FEV1/FVC and FEV1%pred (P < 0.01). Logistic regression showed that HMGB1 was identified to be independent risk factor for T2DM combined with COPD.

conclusionHigh-mobility group box-1 was independent risk factor for T2DM combined with COPD and can be served to predict the occurrence of T2DM combined with COPD.

Indexed as

AgedCase-Control StudiesDiabetes Mellitus, Type 2FemaleHMGB1 ProteinHumansInsulin ResistanceMaleMiddle AgedPulmonary Disease, Chronic ObstructiveRegression AnalysisRespiratory Function TestsHMGB1 ProteinHMGB1 protein, humanchronic obstructive pulmonary diseasehigh-mobility group box-1independent risk factortype 2 diabetes mellitustype 2 diabetes mellitus combined with chronic obstructive pulmonary disease

Identifiers

PMID31129918
PMCPMC6642301
OpenAlexW2946329631

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.