Evidence map›Paper›PMID 31129909›Full record

ArticleNeurotoxicity research2019

Panax notoginsenoside Rb1 Restores the Neurotrophic Imbalance Following Photothrombotic Stroke in Rats.

Chun-Yan Yang, Jian-Yu Yang, Yun-Xia Xiong, Xue-Feng Zhuang, Hui Su, Sheng Hu, Jia-Qing Ma, Xin-Fu Zhou, Hai-Yun Luo, Jun Sun

Abstract read
PubMed Publisher
In one paragraph

Article in Neurotoxicity research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 2 countries.

Chun-Yan YangDepartment of Pharmacology, College of Basic Medicine, Kunming Medical University, Kunming, 650500, Yunnan, People's Republic of China.
Jian-Yu YangDepartment of Pharmacology, College of Basic Medicine, Kunming Medical University, Kunming, 650500, Yunnan, People's Republic of China.
Yun-Xia XiongDepartment of Pharmacology, College of Basic Medicine, Kunming Medical University, Kunming, 650500, Yunnan, People's Republic of China.
Xue-Feng ZhuangDepartment of Pharmacology, College of Basic Medicine, Kunming Medical University, Kunming, 650500, Yunnan, People's Republic of China.
Hui SuDepartment of Pharmacology, College of Basic Medicine, Kunming Medical University, Kunming, 650500, Yunnan, People's Republic of China.
Sheng HuDepartment of Pharmacology, College of Basic Medicine, Kunming Medical University, Kunming, 650500, Yunnan, People's Republic of China.
Jia-Qing MaDepartment of Basic Medical Experiment, College of Basic Medicine, Kunming Medical University, Kunming, 650500, Yunnan, People's Republic of China.
Xin-Fu ZhouSchool of Pharmacy and Medical Sciences, Sansom Institute, University of South Australia, Adelaide, SA, 5001, Australia.
Hai-Yun LuoDepartment of Pharmacology, College of Basic Medicine, Kunming Medical University, Kunming, 650500, Yunnan, People's Republic of China. luohaiyun12@163.com.
Jun SunDepartment of Anatomy, College of Basic Medicine, Kunming Medical University, Kunming, 650500, Yunnan, People's Republic of China. sunjun6661@126.com.
Kunming Medical University · CNUniversity of South Australia · AU

Funding

Joint Special Fund Project of Yunnan Provincial Science and Technology Department-Kunming Medical University 2017FE467-025,160, 163,2017FE468-135,U012017515, 2018FE001(-162)National Natural Science Foundation of China 81760064
6 · The paper itself

Abstract

Mature brain-derived neurotrophic factor (mBDNF) has neuroprotection in cerebral ischemia. Conversely, the precursor of brain-derived neurotrophic factor (proBDNF) has the opposite function to its mature form, inducing apoptosis. However, whether the neuroprotection of Panax notoginsenoside Rb1 (PNS-Rb1) on ischemic stroke is due to, at least partially, its modulation of suppressing proBDNF/P75NTR/sortilin or upregulation of mBDNF is not clear. To test this hypothesis, rats induced by photothrombotic stroke were treated with PNS-Rb1 100 mg/kg or nimodipine 1 mg/kg twice a day until 3, 7, and 14 days. Our data indicate that PNS-Rb1 significantly reduced cerebral infarction rate, proBDNF/P75NTR/sortilin, and plasminogen activator inhibitor-1 (PAI-1) protein levels, and improved sensorimotor dysfunctions induced by ischemic stroke, upregulation of BDNF/TrkB levels, and its processing enzymes (tissue plasminogen activator, tPA) in a time-dependent manner. Taken together, our findings indicate that the improvement of sensorimotor dysfunctions by PNS-Rb1 following ischemic stroke is made, at least partially, by activating the BDNF/TrkB and inhibiting proBDNF/sortilin/P75NTR.

Indexed as

Adaptor Proteins, Vesicular TransportAnimalsBlotting, WesternBrainBrain-Derived Neurotrophic FactorDisease Models, AnimalEnzyme-Linked Immunosorbent AssayMaleMotor SkillsNerve Tissue ProteinsNeuroprotective AgentsPanaxProtein PrecursorsRatsRats, Sprague-DawleyReceptors, Growth FactorAdaptor Proteins, Vesicular TransportBrain-Derived Neurotrophic Factorbrain-derived neurotrophic factor precursorNerve Tissue ProteinsNeuroprotective AgentsNgfr protein, ratNtrk2 protein, ratProtein PrecursorsReceptors, Growth FactorReceptors, Nerve Growth FactorReceptor, trkBsaponin Rb1, Panax notoginsenosideSaponinsSortilinBDNFPanax notoginsenoside Rb1PhotothrombosisproBDNFTrkB

Identifiers

PMID31129909
OpenAlexW2946181287

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.