ArticleBreast cancer research and treatment2019
Combined effect of volumetric breast density and body mass index on breast cancer risk.
Article in Breast cancer research and treatment, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 32 citations in OpenAlex.
- Mammographic breast density and the risk of breast cancer: A systematic review and meta-analysis.Breast (Edinburgh, Scotland) · 2022Pooled it
- Effect of a Randomized Trial of a Web-Based Intervention on Patient-Provider Communication About Breast Density.Journal of women's health (2002) · 2021Trial
- Associations of local breast density with patient characteristics and risk of breast cancer among women undergoing diagnostic breast biopsy.Breast cancer research : BCR · 2026Article
- Interplay of BMI and volumetric breast density measures and breast cancer risk for black and white women.Breast cancer research : BCR · 2025Article
- Incorporating Continuous Mammographic Density Into the BOADICEA Breast Cancer Risk Prediction Model.JCO precision oncology · 2025Article
- Obesity-driven changes in breast tissue exhibit a pro-angiogenic extracellular matrix signature.Matrix biology plus · 2024Article
- Impact of BMI on Prevalence of Dense Breasts by Race and Ethnicity.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2023Article
- Lifetime changes in body fatness and breast density in postmenopausal women: the FEDRA study.Breast cancer research : BCR · 2023Article
- Rat Mammary carcinoma susceptibility 3 (Mcs3) pleiotropy, socioenvironmental interaction, and comparative genomics with orthologous human 15q25.1-25.2.G3 (Bethesda, Md.) · 2023Article
- Prediction of breast cancer risk by automated volumetric breast density measurement.Japanese journal of radiology · 2023Article
- Article
- Cumulative Advanced Breast Cancer Risk Prediction Model Developed in a Screening Mammography Population.Journal of the National Cancer Institute · 2022Article
- The development of a nomogram and the prognostic prediction value of patients with esophageal squamous cell carcinoma undergoing radical radiotherapy.Future science OA · 2022Article
- A case-case analysis of women with breast cancer: predictors of interval vs screen-detected cancer.Breast cancer research and treatment · 2022Article
- Validation of Breast Cancer Risk Models by Race/Ethnicity, Family History and Molecular Subtypes.Cancers · 2021Article
- Association of the Interaction Between Mammographic Breast Density, Body Mass Index, and Menopausal Status With Breast Cancer Risk Among Korean Women.JAMA network open · 2021Observational
- Breast Cancer Population Attributable Risk Proportions Associated with Body Mass Index and Breast Density by Race/Ethnicity and Menopausal Status.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2020Article
- Mammographic density changes during neoadjuvant breast cancer treatment: NeoDense, a prospective study in Sweden.Breast (Edinburgh, Scotland) · 2020Article
- Weighing the Risk: effects of Obesity on the Mammary Gland and Breast Cancer Risk.Journal of mammary gland biology and neoplasia · 2020Review
- Heterogenous Effect of Risk Factors on Breast Cancer across the Breast Density Categories in a Korean Screening Population.Cancers · 2020Article
Corrections and comments
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Authors and funding
18 authors at 8 institutions in 1 country.
Funding
Abstract
backgroundBreast density and body mass index (BMI) are used for breast cancer risk stratification. We evaluate whether the positive association between volumetric breast density and breast cancer risk is strengthened with increasing BMI.
methodsThe San Francisco Mammography Registry and Mayo Clinic Rochester identified 781 premenopausal and 1850 postmenopausal women with breast cancer diagnosed between 2007 and 2015 that had a screening digital mammogram at least 6 months prior to diagnosis. Up to three controls (N = 3535) were matched per case on age, race, date, mammography machine, and state. Volumetric percent density (VPD) and dense volume (DV) were measured with Volpara™. Breast cancer risk was assessed with logistic regression stratified by menopause status. Multiplicative interaction tests assessed whether the association of density measures was differential by BMI categories.
resultsThe increased risk of breast cancer associated with VPD was strengthened with higher BMI for both premenopausal (p
conclusionsThe effect of volumetric percent density on breast cancer risk is strongest in overweight and obese women. These associations have clinical relevance for informing prevention strategies.
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