Evidence map›Paper›PMID 31129786›Full record

ArticleVirus genes2019

Genetic characterization of hemagglutinin (HA) gene of influenza A viruses circulating in Southwest India during 2017 season.

Anitha Jagadesh, Anjana Krishnan, Sudheesh Nair, Saritha Sivadas, Govindakarnavar Arunkumar

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Article in Virus genes, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.4field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 13 citations in OpenAlex.

  1. Molecular Evolution of Influenza A Viruses From Mauritius, 2017-2019.Influenza and other respiratory viruses · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Anitha JagadeshManipal Centre for Virus Research, Regional Reference Laboratory for Influenza Virus & ICMR Virology Network Laboratory- Grade I, Manipal Academy of Higher Education (Deemed to be University), Manipal, Karnataka, 576104, India.
Anjana KrishnanManipal Centre for Virus Research, Regional Reference Laboratory for Influenza Virus & ICMR Virology Network Laboratory- Grade I, Manipal Academy of Higher Education (Deemed to be University), Manipal, Karnataka, 576104, India.
Sudheesh NairManipal Centre for Virus Research, Regional Reference Laboratory for Influenza Virus & ICMR Virology Network Laboratory- Grade I, Manipal Academy of Higher Education (Deemed to be University), Manipal, Karnataka, 576104, India.
Saritha SivadasManipal Centre for Virus Research, Regional Reference Laboratory for Influenza Virus & ICMR Virology Network Laboratory- Grade I, Manipal Academy of Higher Education (Deemed to be University), Manipal, Karnataka, 576104, India.
Govindakarnavar ArunkumarManipal Centre for Virus Research, Regional Reference Laboratory for Influenza Virus & ICMR Virology Network Laboratory- Grade I, Manipal Academy of Higher Education (Deemed to be University), Manipal, Karnataka, 576104, India. arunviro@gmail.com.
Manipal Academy of Higher Education · IN

Funding

Indian Council of Medical Research 5/8/7/15/2010/ECD-1
6 · The paper itself

Abstract

Molecular surveillance of influenza viruses is essential for early detection of novel variants. The aim of the present study was to analyze the hemagglutinin gene of influenza A(H1N1)pdm09 and A(H3N2) viruses circulating during the 2017 season. To investigate the genetic diversity of hemagglutinin gene of influenza A(H1N1)pdm09 and A(H3N2) viruses from 2017 season, ten samples from each subtype were sequenced and analyzed. The season was predominated by influenza A(H1N1)pdm09 viruses. Ten samples were sequenced from each subtype and all sequenced influenza A(H1N1)pdm09 and A(H3N2) viruses belonged to clades 6B.1 and 3C.2a, respectively. Sequence analysis of H1 gene in comparison to 2010-2016 vaccine strain showed mutations K166Q and S188T (K180Q and S202T here) that most likely resulted in antigenic drift and emergence of variant viruses. H3 gene substitutions N137K, N187K, I422V, and G500E that define clade 3C.2a1 were detected during analysis of sequences in comparison to 2017-2018 vaccine strain of northern hemisphere. These substitutions contributed to the change of WHO's recommendation of the 2018-2019 vaccine strain for northern hemisphere. The results of this study provide insights about the continuous genetic variability of the HA gene.

Indexed as

DNA, ViralGenetic VariationHemagglutinin Glycoproteins, Influenza VirusHumansIndiaInfluenza A Virus, H1N1 SubtypeInfluenza A Virus, H3N2 SubtypeInfluenza, HumanProtein ConformationSeasonsSequence Analysis, DNADNA, ViralHemagglutinin Glycoproteins, Influenza Virushemagglutinin, human influenza A virusH1 geneH3 geneInfluenzaMutationsVariant viruses

Identifiers

PMID31129786
OpenAlexW2946712706

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.