ArticleEuropean journal of nutrition2020
Subclinical inflammation, telomere shortening, homocysteine, vitamin B6, and mortality: the Ludwigshafen Risk and Cardiovascular Health Study.
Article in European journal of nutrition, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 1 of them a synthesis that pooled it.
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Who cites it
39 citing papers in PubMed, 1 synthesis or guideline pooled it, 61 citations in OpenAlex.
- Dose-Response Association of Dietary Inflammatory Potential with All-Cause and Cause-Specific Mortality.Advances in nutrition (Bethesda, Md.) · 2022Pooled it
- A Twin Study on the Relation Between Positive Mental Health and Biological Aging.International journal of molecular sciences · 2026Article
- Effects of intergenerational parent-child separation on early eruption of permanent molar and telomere length: a cross-sectional study among Chinese children aged 3-6 years.BMC oral health · 2026Article
- Dietary inflammatory potential and dietary quality in relation to advanced cardiovascular-kidney-metabolic syndrome and mortality risk: traditional and machine learning-based analysis.Nutrition journal · 2026Article
- The novel nutritional metabolic risk index and established triglyceride-glucose indices in type 2 diabetes: modifying role of biological aging assessed by telomere length.Frontiers in nutrition · 2026Article
- Article
- Relationship between plasma homocysteine and clinical grading of varicocele.Asian journal of andrology · 2025Article
- Effects of molecular interactions between the exposome and oxylipin metabolism on healthspan.Frontiers in physiology · 2025Review
- Homocysteine Blood Levels and Mandatory Folic Acid Fortification in Serbia.Current pharmaceutical design · 2025Article
- The Impact of the Mediterranean Diet on Telomere Biology: Implications for Disease Management-A Narrative Review.Nutrients · 2024Review
- Article
- Association between Homocysteine and Vitamin D Levels in Asymptomatic Korean Adults.Nutrients · 2024Article
- A Proactive Intervention Study in Metabolic Syndrome High-Risk Populations Using Phenome-Based Actionable P4 Medicine Strategy.Phenomics (Cham, Switzerland) · 2024Article
- Relationship of Low Vitamin B6 Status with Sarcopenia, Frailty, and Mortality: A Narrative Review.Nutrients · 2024Review
- Associations of serum vitamin B6 status with the risks of cardiovascular, cancer, and all-cause mortality in the elderly.Frontiers in immunology · 2024Article
- High-Dose Vitamin B6 (Pyridoxine) Displays Strong Anti-Inflammatory Properties in Lipopolysaccharide-Stimulated Monocytes.Biomedicines · 2023Article
- Strong associations of telomere length and mitochondrial copy number with suicidality and abuse history in adolescent depressed individuals.Molecular psychiatry · 2023Article
- Physiological Associations between Vitamin B Deficiency and Diabetic Kidney Disease.Biomedicines · 2023Review
- Association between B-vitamins intake and frailty among patients with chronic obstructive pulmonary disease.Aging clinical and experimental research · 2023Article
- Low Magnesium in Conjunction with High Homocysteine and Less Sleep Accelerates Telomere Attrition in Healthy Elderly Australian.International journal of molecular sciences · 2023Article
Corrections and comments
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Authors and funding
8 authors at 7 institutions in 3 countries.
Funding
Abstract
purposeShort telomeres and B vitamin deficiencies have been proposed as risk factors for age-related diseases and mortality that interact through oxidative stress and inflammation. However, available data to support this concept are insufficient. We aimed to investigate the predictive role of B vitamins and homocysteine (HCY) for mortality in cardiovascular patients. We explored potential relationships between HCY, B vitamins, relative telomere length (RTL), and indices of inflammation.
methodsVitamin B6, HCY, interleukin-6 (IL-6), high-sensitive-C-reactive protein (hs-CRP), and RTL were measured in participants of the Ludwigshafen Risk and Cardiovascular Health Study. Death events were recorded over a median follow-up of 9.9 years.
resultsAll-cause mortality increased with higher concentrations of HCY and lower vitamin B6. Patients in the 4th quartile of HCY and vitamin B6 had hazard ratios (HR) for all-cause mortality of 2.77 (95% CI 2.28-3.37) and 0.41(95% CI 0.33-0.49), respectively, and for cardiovascular mortality of 2.78 (95% CI 2.29-3.39) and 0.40 (95% CI 0.33-0.49), respectively, compared to those in the 1st quartile. Multiple adjustments for confounders did not change these results. HCY and vitamin B6 correlated with age-corrected RTL (r = - 0.086, p < 0.001; r = 0.04, p = 0.031, respectively), IL-6 (r = 0.148, p < 0.001; r = - 0.249, p < 0.001, respectively), and hs-CRP (r = 0.101, p < 0.001; r = - 0.320, p < 0.001, respectively). Subjects with the longest telomeres had a significantly higher concentration of vitamin B6, but lower concentrations of HCY, IL-6, and hs-CRP. Multiple regression analyses identified HCY as an independent negative predictor of age-corrected RTL.
conclusionsIn conclusion, hyperhomocysteinemia and vitamin B6 deficiency are risk factors for death from any cause. Hyperhomocysteinemia and vitamin B6 deficiency correlate with increased mortality. This correlation might, at least partially, be explained by accelerated telomere shortening induced by oxidative stress and systemic inflammation in these circumstances.
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