Evidence map›Paper›PMID 31129603›Full record

ArticleBMJ open2019

Randomised, placebo-controlled, double-blind, double-dummy, multicentre trial comparing electronic cigarettes with nicotine to varenicline and to electronic cigarettes without nicotine: the ECSMOKE trial protocol.

Ivan Berlin, Bertrand Dautzenberg, Blandine Lehmann, Jessica Palmyre, Emmanuelle Liégey, Yann De Rycke, Florence Tubach

Registry-linked trialOpen access · goldAbstract readComparative StudyClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in BMJ open, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03630614 (A Randomized, Placebo Controlled, Double Blind, Double Dummy, Multicenter Trial Comparing Electronic Cigarettes With Nicotine to Varenicline and to Electronic Cigarettes Without Nicotine.), which is not on this map. Cited by 13 papers, 9 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 9 pooled it
1.3field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03630614 phase3active not recruitingnot on this map

A Randomized, Placebo Controlled, Double Blind, Double Dummy, Multicenter Trial Comparing Electronic Cigarettes With Nicotine to Varenicline and to Electronic Cigarettes Without Nicotine.

TypeinterventionalSponsorAssistance Publique - Hôpitaux de ParisRan2018 to 2029Enrolled650ConditionsSmoking Cessation, Smoking, Cigarette, Electronic CigaretteArmsElectronic cigarette without nicotine (ECwN) plus active varenicline tablets, Electronic cigarette without nicotine (ECwoN) plus placebo tablets of varenicline, Electronic cigarette with nicotine (ECwN) plus placebo tablets of varenicline
3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 9 syntheses or guidelines pooled it, 21 citations in OpenAlex.

  1. Electronic cigarettes for smoking cessation.The Cochrane database of systematic reviews · 2025
    Pooled it
  2. Electronic cigarettes for smoking cessation.The Cochrane database of systematic reviews · 2024
    Pooled it
  3. Nicotine receptor partial agonists for smoking cessation.The Cochrane database of systematic reviews · 2023
    Pooled it
  4. Electronic cigarettes for smoking cessation.The Cochrane database of systematic reviews · 2022
    Pooled it
  5. Pooled it
  6. Interventions for preventing weight gain after smoking cessation.The Cochrane database of systematic reviews · 2021
    Pooled it
  7. Electronic cigarettes for smoking cessation.The Cochrane database of systematic reviews · 2021
    Pooled it
  8. Electronic cigarettes for smoking cessation.The Cochrane database of systematic reviews · 2021
    Pooled it
  9. Electronic cigarettes for smoking cessation.The Cochrane database of systematic reviews · 2020
    Pooled it
  10. Article
  11. Article
  12. Journal Club-Electronic Cigarettes and Vaping as a Harm Reduction Alternative: Really?Chronic obstructive pulmonary diseases (Miami, Fla.) · 2019
    Article
  13. Electronic Cigarettes Versus Varenicline for Smoking Cessation: A Systematic Review and Meta-analysis of in-person Support Augmentation Strategies.Indian journal of community medicine : official publication of Indian Association of Preventive & Social Medicine
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Ivan BerlinDépartement de pharmacologie, Hôpital Universitaire Pitié Salpêtrière, Paris, France.ORCID 0000-0002-5928-5616
Bertrand DautzenbergDépartement de pharmacologie, Hôpital Universitaire Pitié Salpêtrière, Paris, France.
Blandine LehmannAgence générale des équipements et produits de santé, Assistance Publique-Hopitaux de Paris, Paris, France.
Jessica PalmyreUnité de Recherche Clinique, Assistance Publique-Hopitaux de Paris, Paris, France.
Emmanuelle LiégeyDélégation à la Recherche Clinique et à l'Innovation, Assistance publique-Hôpitaux de Paris, Paris, France.
Yann De RyckeDépartement Biostatistique Santé Publique et Information Médicale, Centre de Pharmacoépidémiologie (Cephepi), INSERM, AP-HP, Hôpital Pitié-Salpêtrière, Paris, France.
Florence TubachDépartement Biostatistique Santé Publique et Information Médicale, Centre de Pharmacoépidémiologie (Cephepi), INSERM, AP-HP, Hôpital Pitié-Salpêtrière, Paris, France.
Assistance Publique – Hôpitaux de Paris · FRInserm · FRSorbonne Université · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionElectronic cigarettes (EC) mainly with nicotine content are widely used worldwide. Although the number of publications about its use is increasing exponentially, evidence-based, unbiased, conclusive, head-to-head comparisons about its efficacy and safety as an aid for smoking cessation are lacking. METHODS AND ANALYSIS: ETHICS AND DISSEMINATION: The ethics committee approval was obtained on 17 April 2018. All data collected about the study participants will be anonymised. Investigators will communicate trial results to participants, health authorities, healthcare professionals, the public and other relevant groups without any publication restrictions. TRIAL REGISTRATION NUMBER: NCT03630614; Pre-results.

Indexed as

Electronic Nicotine Delivery SystemsResearch DesignAdolescentAdultAgedDouble-Blind MethodFemaleHumansMaleMiddle AgedMulticenter Studies as TopicNicotineNicotinic AgonistsRandomized Controlled Trials as TopicSmoking CessationTreatment OutcomeNicotineNicotinic AgonistsVareniclineelectronic cigarettesrandomised, controlled, double dummy trialsmoking cessationvarenicline

Identifiers

PMID31129603
PMCPMC6538086
OpenAlexW2945408945

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.