Evidence map›Paper›PMID 31129235›Full record

ReviewNeuroscience and biobehavioral reviews2019

Sex differences in fear extinction.

E R Velasco, A Florido, M R Milad, R Andero

Abstract readReview
In one paragraph

Review in Neuroscience and biobehavioral reviews, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 71 papers.

0numbers the graph read from it
0cells of the map it votes in
71citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

71 citing papers in PubMed.

  1. Trial
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  11. Reduction in Reward-Driven Behavior Depends on the Basolateral But Not Central Nucleus of the Amygdala in Female Rats.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025
    Article
  12. Article
  13. Merkel cell stimulation in fear and sensory signaling.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2025
    Article
  14. Article
  15. Article
  16. Review
  17. Article
  18. Article
  19. Sex Differences in Neural Circuits Underlying Fear Processing.Current topics in behavioral neurosciences · 2025
    Review
  20. Article

11 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

E R VelascoInstitut de Neurociències, Universitat Autònoma de Barcelona, Spain.
A FloridoInstitut de Neurociències, Universitat Autònoma de Barcelona, Spain.
M R MiladDepartment of Psychiatry, University of Illinois at Chicago, USA.
R AnderoInstitut de Neurociències, Universitat Autònoma de Barcelona, Spain; CIBERSAM, Corporació Sanitaria Parc Taulí, Sabadell, Spain; Department of Psychobiology and Methodology of Health Sciences, Universitat Autònoma de Barcelona, Spain. Electronic address: raul.andero@uab.cat.

Funding

Identifying neural mechanisms of PTSD symptom reduction induced by combined estrogen and prolonged exposure therapyR61MH111907 · NIMH · UNIVERSITY OF ILLINOIS AT CHICAGO · PI MILAD, MOHAMMED R · 2017 to 2018
$1.5M
NIMH NIH HHS R61 MH111907
6 · The paper itself

Abstract

Despite the exponential increase in fear research during the last years, few studies have included female subjects in their design. The need to include females arises from the knowledge gap of mechanistic processes underlying the behavioral and neural differences observed in fear extinction. Moreover, the exact contribution of sex and hormones in relation to learning and behavior is still largely unknown. Insights from this field could be beneficial as fear-related disorders are twice as prevalent in women compared to men. Here, we review an up-to-date summary of animal and human studies in adulthood that report sex differences in fear extinction from a structural and functional approach. Furthermore, we describe how these factors could contribute to the observed sex differences in fear extinction during normal and pathological conditions.

Indexed as

Sex CharacteristicsAnimalsBrainExtinction, PsychologicalFearFemaleHumansMaleExtinctionFearFemaleHumanMaleRodentSex

Identifiers

PMID31129235
PMCPMC6692252

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.