ReviewBest practice & research. Clinical obstetrics & gynaecology2019
Tranexamic acid for post-partum haemorrhage: What, who and when.
Review in Best practice & research. Clinical obstetrics & gynaecology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 2 syntheses or guidelines pooled it, 59 citations in OpenAlex.
- Twin pregnancy and postpartum haemorrhage: a systematic review and meta-analysis.BMC pregnancy and childbirth · 2024Pooled it
- Complications Associated with Rhinoplasty: An Umbrella Review of Meta-analyses.Aesthetic plastic surgery · 2022Pooled it
- Effectiveness of tranexamic acid in intervening postpartum vaginal lacerations.BMC pregnancy and childbirth · 2025Trial
- Improving Obstetric Safety in Postpartum Hemorrhage: Impact of Protocol-Based Conservative Management.Life (Basel, Switzerland) · 2026Review
- Rapid detection of fibrinolytic activation in postpartum hemorrhage and acute obstetric coagulopathy using a novel assay.Blood advances · 2026Article
- Assessment of Structural and Process Readiness for Postpartum Haemorrhage Care in Uganda and Ghana: A Mixed Methods Study.BJOG : an international journal of obstetrics and gynaecology · 2025Article
- The role of tranexamic acid in reducing postpartum hemorrhage in high-risk pregnancies.AJOG global reports · 2025Article
- Management of Postpartum Hemorrhage in Low- and Middle-Income Countries: Emergency Need for Updated Approach Due to Specific Circumstances, Resources, and Availabilities.Journal of clinical medicine · 2024Review
- Review
- Placenta praevia.BJA education · 2024Article
- Postpartum Hemorrhage: Enhancing Outcomes for Mothers by Effective Management.Journal of obstetrics and gynaecology of India · 2024Article
- Tranexamic Acid Use in Obstetric Hemorrhage: Knowledge and Attitude Among Jordanian Obstetricians and Gynecologists.Cureus · 2024Article
- Safety assessment of tranexamic acid: real-world adverse event analysis from the FAERS database.Frontiers in pharmacology · 2024Article
- A comparative study of the local effect of tranexamic acid and phenylephrine on the amount of bleeding in rhinoplasty: A randomized clinical trial.Caspian journal of internal medicine · 2024Article
- Improving early infant diagnosis for HIV-exposed infants using unmanned aerial vehicles for blood sample transportation in Conakry, Guinea: a comparative cost-effectiveness analysis.BMJ global health · 2023Article
- Effectiveness of Tranexamic Acid in Reducing Hemorrhage in Isolated Blunt Solid Organ Injury.Cureus · 2021Article
- Bleeding Disorders in Primary Fibrinolysis.International journal of molecular sciences · 2021Review
- Review
- The value of the portable fibrinogen measuring device-a case report of severe postpartum hemorrhage with obstetric disseminated intravascular coagulation.JA clinical reports · 2021Article
- The many roles of tranexamic acid: An overview of the clinical indications for TXA in medical and surgical patients.European journal of haematology · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Tranexamic acid reduces bleeding by inhibiting the breakdown of blood clots. It is cost-effective and heat-stable with a long shelf life. In the WOMAN trial, tranexamic acid reduced deaths due to bleeding with no increase in thromboembolic events. The effect was greatest when women received tranexamic acid within 3 h of childbirth (RR = 0.69, 95% CI 0.52-0.91). The WHO recommends that women with post-partum haemorrhage receive 1 g tranexamic acid intravenously as soon as possible after giving birth, followed by a second dose if bleeding continues after 30 min or restarts within 24 h since the first dose. Urgent treatment is critical because women with post-partum haemorrhage bleed to death quickly, and tranexamic acid is most effective when given early. Evidence suggests there is no benefit when the drug is given more than 3 h after bleeding onset. Alternative routes of administration and use of tranexamic acid in the prevention of post-partum haemorrhage are research priorities.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.