Evidence map›Paper›PMID 31128574›Full record

ArticleAging2019

The small non-coding RNA profile of mouse oocytes is modified during aging.

Bettina P Mihalas, Nicole J Camlin, Miguel J Xavier, Alexandra E Peters, Janet E Holt, Jessie M Sutherland, Eileen A McLaughlin, Andrew L Eamens, Brett Nixon

Open access · hybridAbstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Aging, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.5field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 13 citations in OpenAlex.

  1. Review
  2. Ovarian aging: energy metabolism of oocytes.Journal of ovarian research · 2024
    Review
  3. Article
  4. Article
  5. Article
  6. Mouse Oocytes, A Complex Single Cell Transcriptome.Frontiers in cell and developmental biology · 2022
    Article
  7. Review
  8. The Impact of Aging on Macroautophagy in the Pre-ovulatory Mouse Oocyte.Frontiers in cell and developmental biology · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 3 countries.

Bettina P MihalasPriority Research Centre for Reproductive Science, Schools of Environmental and Life Sciences and Biomedical Science and Pharmacy, the University of Newcastle, Callaghan, New South Wales 2308, Australia.
Nicole J CamlinDepartment of Biochemistry and Molecular Biology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland 21218, United States.
Miguel J XavierPriority Research Centre for Reproductive Science, Schools of Environmental and Life Sciences and Biomedical Science and Pharmacy, the University of Newcastle, Callaghan, New South Wales 2308, Australia.
Alexandra E PetersPriority Research Centre for Reproductive Science, Schools of Environmental and Life Sciences and Biomedical Science and Pharmacy, the University of Newcastle, Callaghan, New South Wales 2308, Australia.
Janet E HoltPriority Research Centre for Reproductive Science, Schools of Environmental and Life Sciences and Biomedical Science and Pharmacy, the University of Newcastle, Callaghan, New South Wales 2308, Australia.
Jessie M SutherlandPriority Research Centre for Reproductive Science, Schools of Environmental and Life Sciences and Biomedical Science and Pharmacy, the University of Newcastle, Callaghan, New South Wales 2308, Australia.
Eileen A McLaughlinPriority Research Centre for Reproductive Science, Schools of Environmental and Life Sciences and Biomedical Science and Pharmacy, the University of Newcastle, Callaghan, New South Wales 2308, Australia.
Andrew L EamensSchool of Environmental and Life Sciences, the University of Newcastle, Callaghan, New South Wales 2308, Australia.
Brett NixonPriority Research Centre for Reproductive Science, Schools of Environmental and Life Sciences and Biomedical Science and Pharmacy, the University of Newcastle, Callaghan, New South Wales 2308, Australia.
University of Newcastle Australia · AUHunter Medical Research Institute · AUACT GovernmentJohns Hopkins University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Oocytes are reliant on messenger RNA (mRNA) stores to support their survival and integrity during a protracted period of transcriptional dormancy as they await ovulation. Oocytes are, however, known to experience an age-associated alteration in mRNA transcript abundance, a phenomenon that contributes to reduced developmental potential. Here we have investigated whether the expression profile of small non-protein-coding RNAs (sRNAs) is similarly altered in aged mouse oocytes. The application of high throughput sequencing revealed substantial changes to the global sRNA profile of germinal vesicle stage oocytes from young (4-6 weeks) and aged mice (14-16 months). Among these, 160 endogenous small-interfering RNAs (endo-siRNAs) and 10 microRNAs (miRNAs) were determined to differentially accumulate within young and aged oocytes. Further, we revealed decreased expression of two members of the kinesin protein family,

Indexed as

AgingAnimalsbeta KaryopherinsFemaleGene Expression ProfilingMiceMicrotubule-Associated ProteinsOocytesRNA, Small Untranslatedbeta KaryopherinsKifc1 protein, mouseKIFC5 protein, mouseMicrotubule-Associated ProteinsRNA, Small Untranslatedaneuploidyendo-siRNAkinesinmaternal agingmeiosismiRNAoocytesmall non-coding RNA

Identifiers

PMID31128574
PMCPMC6555462
OpenAlexW2945900373

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.