Evidence map›Paper›PMID 31128568›Full record

Trial reportPsychoneuroendocrinology2019

Null results of oxytocin and vasopressin administration across a range of social cognitive and behavioral paradigms: Evidence from a randomized controlled trial.

Benjamin A Tabak, Adam R Teed, Elizabeth Castle, Janine M Dutcher, Meghan L Meyer, Ronnie Bryan, Michael R Irwin, Matthew D Lieberman, Naomi I Eisenberger

Registry-linked trialOpen access · greenAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Psychoneuroendocrinology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01680718 (Neuropeptides and Social Behavior), which is not on this map. Cited by 24 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed, 1 pooled it
9.4field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01680718 early_phase1completednot on this map

Neuropeptides and Social Behavior

TypeinterventionalSponsorUniversity of California, Los AngelesRan2012 to 2013Enrolled160ConditionsSocial PsychologyArmsIntranasal oxytocin, Intranasal vasopressin, Intranasal placebo
3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 1 synthesis or guideline pooled it, 46 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Trial
  4. Review
  5. Article
  6. Article
  7. Review
  8. Review
  9. Review
  10. Article
  11. Evaluating the neuropeptide-social cognition link in ageing: the mediating role of basic cognitive skills.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2022
    Article
  12. Oxytocin-a social peptide? Deconstructing the evidence.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2022
    Review
  13. Review
  14. Article
  15. Illusory Essences: A Bias Holding Back Theorizing in Psychological Science.Perspectives on psychological science : a journal of the Association for Psychological Science · 2022
    Article
  16. Article
  17. Article
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 6 institutions in 1 country.

Benjamin A TabakDepartment of Psychology, Southern Methodist University, Dallas, TX, United States. Electronic address: btabak@smu.edu.
Adam R TeedDepartment of Psychology, Southern Methodist University, Dallas, TX, United States.
Elizabeth CastleDepartment of Psychology, University of California, Los Angeles, CA, United States.
Janine M DutcherDepartment of Psychology, Carnegie Mellon University, Pittsburgh, PA, United States.
Meghan L MeyerDepartment of Psychological and Brain Sciences, Dartmouth College, Hanover, NH, United States.
Ronnie BryanLos Angeles Trade-Tech College, Los Angeles, CA, United States.
Michael R IrwinDepartment of Psychology, University of California, Los Angeles, CA, United States; Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, University of California, Los Angeles, CA, United States; Cousins Center for Psychoneuroimmunology, Jane and Terry Semel Institute for Neuroscience, David Geffen School of Medicine, University of California, Los Angeles, CA, United States.
Matthew D LiebermanDepartment of Psychology, University of California, Los Angeles, CA, United States; Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, University of California, Los Angeles, CA, United States.
Naomi I EisenbergerDepartment of Psychology, University of California, Los Angeles, CA, United States.
University of California, Los Angeles · USSouthern Methodist University · USCarnegie Mellon University · USDartmouth College · USLos Angeles Trade Technical College · USNeurobehavioral Systems · US

Funding

PREVENTION RESEARCH TRAINING:URBAN CHILDREN'S MENT HLTHT32MH015750 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI CHRISTINE DUNKEL SCHETTER · 1985 to 2026
$6.2M
NIMH NIH HHS T32 MH015750
6 · The paper itself

Abstract

Research examining oxytocin and vasopressin in humans has the potential to elucidate neurobiological mechanisms underlying human sociality that have been previously unknown or not well characterized. A primary goal of this work is to increase our knowledge about neurodevelopmental and psychiatric disorders characterized by impairments in social cognition. However, years of research highlighting wide-ranging effects of, in particular, intranasal oxytocin administration have been tempered as the fields of psychology, neuroscience, and other disciplines have been addressing concerns over the reproducibility and validity of research findings. We present a series of behavioral tasks that were conducted using a randomized, double-blind, placebo controlled, between-subjects design, in which our research group found no main effects of oxytocin and vasopressin on a host of social outcomes. In addition to null hypothesis significance testing, we implemented equivalence testing and Bayesian hypothesis testing to examine the sensitivity of our findings. These analyses indicated that 47-83% of our results (depending on the method of post-hoc analysis) had enough sensitivity to detect the absence of a main effect. Our results add to evidence that intranasal oxytocin may have a more limited direct effect on human social processes than initially assumed and suggest that the direct effects of intranasal vasopressin may be similarly limited. Randomized controlled trial registration: NCT01680718.

Indexed as

Administration, IntranasalAdolescentAdultBayes TheoremCognitionDouble-Blind MethodFemaleHumansMaleNegative ResultsOxytocinPlacebo EffectReproducibility of ResultsSocial BehaviorSocial SkillsVasopressinsOxytocinVasopressinsOxytocinSocial behaviorSocial cognitionSocial processesVasopressin

Identifiers

PMID31128568
PMCPMC6687062
OpenAlexW2940659074

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.