ArticleThe journal of allergy and clinical immunology. In practice
Pediatric Hypereosinophilia: Characteristics, Clinical Manifestations, and Diagnoses.
Article in The journal of allergy and clinical immunology. In practice. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 45 citations in OpenAlex.
- Eosinophilic granulomatous inflammation and multi-organ involvement probable caused by Paragonimus heterotremus infection in a pediatric patient: a rare case report.BMC pediatrics · 2026Article
- Assessment of smoking exposure by urine cotinine levels in severe COVID-19 patients: a case-control study.Scientific reports · 2025Observational
- Unusual diagnosis in a Lebanese child with persistent hyper eosinophilia: a case report.Annals of medicine and surgery (2012) · 2025Article
- Review of Paraneoplastic Syndromes in Children with Malignancy.Medical science monitor : international medical journal of experimental and clinical research · 2025Review
- A Retrospective Longitudinal Study of Refugees With Eosinophilia at an Academic Center in the United States From 2015 to 2020.Open forum infectious diseases · 2024Article
- Eosinophilia in children: characteristics, etiology and diagnostic algorithm.European journal of pediatrics · 2023Article
- Characteristics of patients with incidental eosinophilia admitted to a tertiary hospital in southern China.Heliyon · 2023Article
- Eosinophilia and Increased Immunoglobulin E: Is It Really a Primary Immunodeficiency? A Diagnostic Challenge.Turkish archives of pediatrics · 2023Article
- The multidisciplinary approach to eosinophilia.Frontiers in oncology · 2023Review
- Hypereosinophilia in NICU patients with a neonatal lymphatic flow disorder.Journal of perinatology : official journal of the California Perinatal Association · 2022Article
- Parasitic Infections in Internationally Adopted Children: A Twelve-Year Retrospective Study.Pathogens (Basel, Switzerland) · 2022Article
- Strongyloidiasis in Children Outside the Tropics: Do We Need to Increase Awareness?Microorganisms · 2021Article
- Pediatric hypereosinophilia and toxoplasma: Peregrination beyond facileness.Journal of family medicine and primary care · 2021Article
- Review
- Idiopathic hypereosinophilic syndrome: A rare diagnosis in children.Clinical case reports · 2020Article
- Eosinophil responses during COVID-19 infections and coronavirus vaccination.The Journal of allergy and clinical immunology · 2020Review
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundEosinophilia is associated with various conditions, including allergic, infectious, and neoplastic disorders. The diagnostic differential is broad, and data on hypereosinophilia in pediatric patients are limited.
objectiveThe objectives of this study were to identify cases of hypereosinophilia in a tertiary pediatric medical center, determine clinical characteristics and disease associations, and estimate the incidence of hypereosinophilia in the hospital and geographic populations.
methodsA retrospective chart review included patients younger than 18 years presenting to a tertiary pediatric medical center (January 1, 2008, to May 31, 2017) with absolute eosinophil counts (AECs) greater than or equal to 1.50 thousand eosinophils/microliter (K/μL) recorded on at least 2 occasions at least 4 weeks apart (N = 176). Clinical characteristics, laboratory values, treatment course, and associated diagnoses were evaluated.
resultsThe most common cause of hypereosinophilia in this cohort was secondary hypereosinophilia. Atopic dermatitis, graft-versus-host disease, sickle cell disease, and parasitic infections were the most common conditions associated with hypereosinophilia. Median age at diagnosis was 4.6 (interquartile range, 1.5-10.5) years. Median peak AEC was 3.16 (2.46-4.78) K/μL. Hypereosinophilia occurred most frequently in patients aged between 6 and 11 years (24.4%) and younger than 1 year (18.2%). Patients with neoplasms and immune deficiencies had significantly higher peak AECs than did patients with overlap hypereosinophilic syndrome and atopic diseases (P < .0001).
conclusionsPediatric hypereosinophilia has an incidence of 54.4 per 100,000 persons per year, with children younger than 1 year and aged 6 to 11 years accounting for most affected patients. Pediatric hypereosinophilia is not uncommon and remains underrecognized, highlighting a need for clinicians to identify patients who meet criteria for hypereosinophilia and to pursue a thorough evaluation.
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