ArticleJournal of the American Academy of Child and Adolescent Psychiatry2020
The Heterogeneity of Anxious Phenotypes: Neural Responses to Errors in Treatment-Seeking Anxious and Behaviorally Inhibited Youths.
Article in Journal of the American Academy of Child and Adolescent Psychiatry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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18 citing papers in PubMed.
- Neural responses to error in youth: the impact of social context, anxiety, and worry.European child & adolescent psychiatry · 2026Article
- Structural Brain Correlates of Childhood Inhibited Temperament: An ENIGMA-Anxiety Mega-Analysis.Journal of the American Academy of Child and Adolescent Psychiatry · 2026Article
- Infant sensory gating and a developmental cascade to autistic traits and anxiety.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Review
- Adolescent cognitive control processing is associated with anxiety in young adulthood during the COVID-19 pandemic.Cognitive, affective & behavioral neuroscience · 2025Article
- Integrating Multimodal Neuroimaging of Error Monitoring to Estimate Future Anxiety in Adolescents.JAMA network open · 2025Article
- Threat Appraisal and Pediatric Anxiety: Proof of Concept of a Latent Variable Approach.Clinical psychological science : a journal of the Association for Psychological Science · 2024Article
- The genetic architecture of youth anxiety: a study protocol.BMC psychiatry · 2024Article
- Multimodal study of the neural sources of error monitoring in adolescents and adults.Psychophysiology · 2023Article
- Cross-sectional and Longitudinal Associations of Anxiety and Irritability With Adolescents' Neural Responses to Cognitive Conflict.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2023Article
- Developmental Changes in the Association Between Cognitive Control and Anxiety.Child psychiatry and human development · 2022Article
- Hyperbolic trade-off: The importance of balancing trial and subject sample sizes in neuroimaging.NeuroImage · 2022Article
- Article
- Amygdala Functional Connectivity and Negative Reactive Temperament at Age 4 Months.Journal of the American Academy of Child and Adolescent Psychiatry · 2021Article
- Behavioral inhibition and dual mechanisms of anxiety risk: Disentangling neural correlates of proactive and reactive control.JCPP advances · 2021Article
- Cognitive Control in Pediatric Obsessive-Compulsive and Anxiety Disorders: Brain-Behavioral Targets for Early Intervention.Biological psychiatry · 2021Review
- Emotional distractors and attentional control in anxious youth: eye tracking and fMRI data.Cognition & emotion · 2021Article
- Overcontrol and neural response to errors in pediatric anxiety disorders.Journal of anxiety disorders · 2020Article
- Infant behavioral reactivity predicts change in amygdala volume 12 years later.Developmental cognitive neuroscience · 2020Article
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9 authors.
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Abstract
objectiveAlthough behaviorally inhibited (BI) temperament predicts risk for anxiety, anxiety in BI may involve distinct neural responses to errors. The current study examines the relations between anxiety and neural correlates of error processing both in youths identified as BI in early childhood and in youths seeking treatment for an anxiety disorder.
methodAll participants underwent functional magnetic resonance imaging using a flanker task to assess responses to errors. A study in healthy subjects assessed test-retest reliability to inform analyses in two other samples. For one sample, a cohort of BI youths (Low BI, n = 28; High BI, n = 27) was followed into adolescence. For the other, participants were recruited based on the presence or absence of an anxiety disorder. Using identical methods in medication-free subjects, analyses compared relations between anxiety and error processing across the two samples.
resultsError-processing exhibited acceptable reliability. Within a ventromedial-prefrontal-cortex (vmPFC) cluster, anxiety related to error processing only in youths whose early-life BI status was known. In the high BI group, anxiety related to reduced neural response to errors. No such associations manifested in treatment-seeking youths. Other analyses mapped relations between error-processing and anxiety in each sample on its own. However, only the vmPFC cluster statistically differentiated the neural correlates of anxiety in BI.
conclusionBI temperament may define a unique pathway into anxiety involving perturbed neural responding to errors. Although BI is a risk factor for later anxiety, the neural and associated features of anxiety in BI youths may differ from those in treatment-seeking youths.
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