ReviewFrontiers in neuroendocrinology2019
Effects of opioids on the parental brain in health and disease.
Review in Frontiers in neuroendocrinology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 21 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Postpartum Intervention for Mothers With Opioid Use Disorders - Brain-Behavior Mechanisms
Postpartum Intervention for Mothers With Opioid Use Disorders (R33)
Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 34 citations in OpenAlex.
- The neuroscience of social feelings: mechanisms of adaptive social functioning.Neuroscience and biobehavioral reviews · 2021Pooled it
- Global burden and socioeconomic correlates of drug use disorders in women of childbearing age: insights from GBD and NHANES.European archives of psychiatry and clinical neuroscience · 2026Article
- From morphine to buprenorphine - Modeling opioid use disorder and its treatment during pregnancy: Effects on maternal care and offspring neurodevelopment in a translational rodent model.Pharmacology, biochemistry, and behavior · 2025Article
- Ontogenic, Immunological, and Behavioral Changes of Crack Cocaine Exposure During the Gestational Period.Molecular neurobiology · 2025Article
- Peripartum buprenorphine and oxycodone exposure impair maternal behavior and increase neuroinflammation in new mother rats.Brain, behavior, and immunity · 2025Article
- Gestational Opioid Exposure: From Morphine to MOUD - How Opioids Impact Offspring Development and Maternal Care.Current topics in behavioral neurosciences · 2025Review
- Roles of Maternal Substance Use, Posttraumatic Stress, And Parenting Practices In Predicting Child Conduct Problems.Journal of child and family studies · 2023Article
- Path of intuitive compassion to transform conflicts into enduring peace and prosperity: Symmetry across domains of reiterated prisoner's dilemma, dyadic active inference, and Mahayana Buddhism.Frontiers in psychology · 2023Article
- Compassion within conflict: Toward a computational theory of social groups informed by maternal brain physiology.The Behavioral and brain sciences · 2022Article
- Intersubjectivity as an antidote to stress: Using dyadic active inference model of intersubjectivity to predict the efficacy of parenting interventions in reducing stress-through the lens of dependent origination in Buddhist Madhyamaka philosophy.Frontiers in psychology · 2022Article
- Parenting and addictions: Current insights from human neuroscience.Current addiction reports · 2021Article
- Opioids and maternal brain-behavior adaptation.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2021Article
- The Value of Mechanistic Experiments to Target the Shared Neural Circuitry of Parenting and Addiction: The Potential for Video Feedback Interventions.Frontiers in psychology · 2021Article
- How stress can influence brain adaptations to motherhood.Frontiers in neuroendocrinology · 2021Review
- Neurobiology of peripartum mental illness.Handbook of clinical neurology · 2021Review
- Reduced Child-Oriented Face Mirroring Brain Responses in Mothers With Opioid Use Disorder: An Exploratory Study.Frontiers in psychology · 2021Article
- Neurobiological changes during the peripartum period: implications for health and behavior.Social cognitive and affective neuroscience · 2020Review
- Challenges for Women Entering Treatment for Opioid Use Disorder.Current psychiatry reports · 2020Review
- Potential Neural Mediators of Mom Power Parenting Intervention Effects on Maternal Intersubjectivity and Stress Resilience.Frontiers in psychiatry · 2020Article
- Early postpartum resting-state functional connectivity for mothers receiving buprenorphine treatment for opioid use disorder: A pilot study.Journal of neuroendocrinology · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
The epidemic of opioid use disorder (OUD) directly affects millions of women of child-bearing age. Unfortunately, parenting behaviors - among the most important processes for human survival - are vulnerable to the effects of OUD. The standard of care for pregnant women with OUD is opioid maintenance therapy (OMT), of which the primary objective is to mitigate addiction-related stress. The aim of this review is to synthesize current information specific to pregnancy and parenting that may be affected by OUD. We first summarize a model of the parental brain supported by animal research and human neuroimaging. We then review animal models of exogenous opioid effects on parental brain and behavior. We also present preliminary data for a unifying hypothesis that may link different effects of exogenous opioids on parenting across species and in the context of OMT. Finally, we discuss future directions that may inform research and clinical decision making for peripartum women with OUD.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.