ArticleSystematic biology2020
Analysis of Spounaviruses as a Case Study for the Overdue Reclassification of Tailed Phages.
Article in Systematic biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 83 papers.
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Who cites it
83 citing papers in PubMed, 137 citations in OpenAlex.
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- Biological characteristics and genome analysis of Citrobacter freundii phage K1M.Archives of virology · 2025Article
- Characterization and therapeutic potential of newly isolated bacteriophages againstJournal of virology · 2025Article
- taxMyPhage: Automated Taxonomy of dsDNA Phage Genomes at the Genus and Species Level.PHAGE (New Rochelle, N.Y.) · 2025Article
- Self-splicing introns in genes of Bastillevirinae bacteriophages.Nucleic acids research · 2025Article
- Characterization, diversity, and biogeochemical potential of soil viruses inhabiting in Yuncheng Salt Lake.Frontiers in microbiology · 2025Article
- In Vitro Susceptibility of Clinical and Carrier Strains ofInternational journal of molecular sciences · 2024Article
- Recent Progress in Terrestrial Biota Derived Antibacterial Agents for Medical Applications.Molecules (Basel, Switzerland) · 2024Review
- Complete genome sequences ofMicrobiology resource announcements · 2024Article
- Phylogeny and disease associations of a widespread and ancient intestinal bacteriophage lineage.Nature communications · 2024Article
- The virtue of training: extending phage host spectra against vancomycin-resistantAntimicrobial agents and chemotherapy · 2024Article
- Isolation and characterization of lytic bacteriophages from various sources in Addis Ababa against antimicrobial-resistant diarrheagenic Escherichia coli strains and evaluation of their therapeutic potential.BMC infectious diseases · 2024Article
- Proton Pump Inhibitor Use and Complications of Cirrhosis Are Linked With Distinct Gut Microbial Bacteriophage and Eukaryotic Viral-Like Particle Signatures in Cirrhosis.Clinical and translational gastroenterology · 2024Article
23 more citing papers are in PubMed but not listed here.
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Authors and funding
21 authors at 18 institutions in 12 countries.
Funding
Abstract
Tailed bacteriophages are the most abundant and diverse viruses in the world, with genome sizes ranging from 10 kbp to over 500 kbp. Yet, due to historical reasons, all this diversity is confined to a single virus order-Caudovirales, composed of just four families: Myoviridae, Siphoviridae, Podoviridae, and the newly created Ackermannviridae family. In recent years, this morphology-based classification scheme has started to crumble under the constant flood of phage sequences, revealing that tailed phages are even more genetically diverse than once thought. This prompted us, the Bacterial and Archaeal Viruses Subcommittee of the International Committee on Taxonomy of Viruses (ICTV), to consider overall reorganization of phage taxonomy. In this study, we used a wide range of complementary methods-including comparative genomics, core genome analysis, and marker gene phylogenetics-to show that the group of Bacillus phage SPO1-related viruses previously classified into the Spounavirinae subfamily, is clearly distinct from other members of the family Myoviridae and its diversity deserves the rank of an autonomous family. Thus, we removed this group from the Myoviridae family and created the family Herelleviridae-a new taxon of the same rank. In the process of the taxon evaluation, we explored the feasibility of different demarcation criteria and critically evaluated the usefulness of our methods for phage classification. The convergence of results, drawing a consistent and comprehensive picture of a new family with associated subfamilies, regardless of method, demonstrates that the tools applied here are particularly useful in phage taxonomy. We are convinced that creation of this novel family is a crucial milestone toward much-needed reclassification in the Caudovirales order.
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Registered trials
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