ArticleClinical infectious diseases : an official publication of the Infectious Diseases Society of America2020
Risk Factors for Tuberculosis and Effect of Preventive Therapy Among Close Contacts of Persons With Infectious Tuberculosis.
Article in Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 50 citations in OpenAlex.
- Responding to a protracted tuberculosis outbreak: lessons from multiple rounds of investigation in a Chinese boarding school.Annals of medicine · 2026Article
- Long-Term Trends and Determinants of Tuberculosis Burden in China, 1990-2023: Insights from the Global Burden of Disease Study 2023.Pathogens (Basel, Switzerland) · 2026Article
- Body Mass Index and Incident Tuberculosis in Close Tuberculosis Contacts.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2026Observational
- Timing matters in macrophage/CD4+ T cell interactions: an agent-based model comparingmSystems · 2025Article
- Exposure Time to a Tuberculosis Index Case as a Marker of Infection in Immigrant Populations.Pathogens (Basel, Switzerland) · 2025Article
- Tuberculosis Preventive Treatment in High TB-Burden Settings: A State-of-the-Art Review.Drugs · 2025Review
- The yield of tuberculosis contact investigation in São Paulo, Brazil: a community-based cross-sectional study.Epidemiology and infection · 2025Article
- Timing and predictors of disease incidence among named contacts of reported tuberculosis patients in a low incidence setting.PloS one · 2025Article
- Transcriptomic Signatures of Progression to Tuberculosis Disease Among Close Contacts in Brazil.The Journal of infectious diseases · 2024Article
- Surveillance of close contacts of patients with infectious tuberculosis: a prospective cohort study.Antimicrobial resistance and infection control · 2024Article
- Using the Health Belief Model to Predict Tuberculosis Preventive Behaviors Among Tuberculosis Patients' Household Contacts During the COVID-19 Pandemic in the Border Areas of Northern Thailand.Journal of preventive medicine and public health = Yebang Uihakhoe chi · 2024Article
- Capturing RecentTropical medicine and infectious disease · 2024Article
- Predicting stringent QuantiFERON-TB Gold Plus conversions in contacts of tuberculosis patients.Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi · 2023Article
- Contribution of Reinfection to Annual Rate of Tuberculosis Infection (ARI) and Incidence of Tuberculosis Disease.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2023Article
- Assessing the spatial heterogeneity of tuberculosis in a population with internal migration in China: a retrospective population-based study.Frontiers in public health · 2023Article
- Patterns of Childhood Tuberculosis Diagnosis in Hawassa University Comprehensive Specialized Hospital, Hawassa, Sidama Regional State, Ethiopia.Pediatric health, medicine and therapeutics · 2022Article
- Tuberculosis infection among youths in overcrowded university hostels in Kenya: a cross-sectional study.Tropical medicine and health · 2021Article
- Management ofOpen forum infectious diseases · 2021Article
- Antigen-Specific T-Cell Activation Distinguishes between Recent and Remote Tuberculosis Infection.American journal of respiratory and critical care medicine · 2021Observational
- Ethical issues in the access to emergency care for undocumented immigrants.Journal of the American College of Emergency Physicians open · 2021Article
Corrections and comments
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Authors and funding
10 authors at 8 institutions in 1 country.
Funding
Abstract
backgroundClose contacts of persons with pulmonary tuberculosis (TB) have high rates of TB disease.
methodsWe prospectively enrolled TB patients and their close contacts at 9 US/Canadian sites. TB patients and contacts were interviewed to identify index patient, contact, and exposure risk factors for TB. Contacts were evaluated for latent TB infection (LTBI) and TB, and the effectiveness of LTBI treatment for preventing contact TB was examined.
resultsAmong 4490 close contacts, multivariable risk factors for TB were age ≤5 years, US/Canadian birth, human immunodeficiency virus infection, skin test induration ≥10 mm, shared bedroom with an index patient, exposure to more than 1 index patient, and index patient weight loss (P < .05 for each). Of 1406 skin test-positive contacts, TB developed in 49 (9.8%) of 446 who did not initiate treatment, 8 (1.8%) of 443 who received partial treatment, and 1 (0.2%) of 517 who completed treatment (1951, 290, and 31 cases/100 000 person-years, respectively; P < .001). TB was diagnosed in 4.2% of US/Canadian-born compared with 2.3% of foreign-born contacts (P = .002), and TB rates for US/Canadian-born and foreign-born contacts who did not initiate treatment were 3592 and 811 per 100 000 person-years, respectively (P < .001).
conclusionsTreatment for LTBI was highly effective in preventing TB among close contacts of infectious TB patients. Several index patient, contact, and exposure characteristics associated with increased risk of contact TB were identified. These findings help inform contact investigation, LTBI treatment, and other public health prevention efforts.
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