ReviewEndocrine reviews2019
Inflammation in the Pathophysiology and Therapy of Cardiometabolic Disease.
Review in Endocrine reviews, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 74 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
74 citing papers in PubMed, 2 syntheses or guidelines pooled it, 122 citations in OpenAlex.
- Relationship Between Clusters of Multimorbidity and Dementia Risk: A Systematic Review.International journal of geriatric psychiatry · 2025Pooled it
- Effects of resistant starch interventions on circulating inflammatory biomarkers: a systematic review and meta-analysis of randomized controlled trials.Nutrition journal · 2020Pooled it
- Plant-Derived Polyphenol Salvianolic Acid B Attenuates Cardiomyocyte Pyroptosis by Modulating the MMP12-NLRP3 Signaling Axis.Food science & nutrition · 2026Article
- Revisiting Insulin Resistance in the Pathophysiology of Type 2 Diabetes Mellitus: A Multi-Organ Perspective.Diabetes & metabolism journal · 2026Review
- Article
- Emerging Cardiovascular Risk Factors in Chronic Kidney Disease in the "Omics" Era: Gut and Beyond.Mayo Clinic proceedings · 2026Review
- The Promising Role of Selected Fibroblast Growth Factors as Potential Markers of Complications in Type 1 and Type 2 Diabetes.International journal of molecular sciences · 2025Article
- Impact of (poly)phenol-rich dietary sources on DNA damage: insights from human intervention studies using the Comet assay - a review and perspective.The British journal of nutrition · 2025Review
- Associations of cardiometabolic multimorbidity with all-cause dementia, alzheimer's disease, and vascular dementia: a cohort study in the UK biobank.BMC public health · 2025Article
- A Comprehensive Pilot Study to Elucidate the Distinct Gut Microbial Composition and Its Functional Significance in Cardio-Metabolic Disease.Biochemical genetics · 2025Article
- The novel role ofJournal of diabetes and metabolic disorders · 2025Article
- Accelerated Biological Aging and Longitudinal Progression of Cardiometabolic Disease, Subsequent Dementia, and Death: A Multistate Analysis.European journal of neurology · 2025Article
- Inflammatory markers mediate the association between weight-adjusted waist circumference and mortality in patients with cardiometabolic syndrome.Scientific reports · 2025Article
- The association of dietary approaches to stop hypertension measured by the food frequency questionnaire with metabolic syndrome and some inflammatory biomarkers in adolescents with obesity: a case-control study.Journal of health, population, and nutrition · 2025Article
- Heat-moisture-treated rice improves oral glucose tolerance by modulating serum and fecal metabolites in mice.Frontiers in nutrition · 2025Article
- Joint and Temporal Relationships of Systemic Inflammation and Atherogenic Dyslipidemia with Risk of Cardiometabolic Disease: A Longitudinal Cohort Study.Journal of inflammation research · 2025Article
- Clockwork conditioning: Aligning the skeletal muscle clock with time-of-day exercise for cardiometabolic health.Journal of molecular and cellular cardiology · 2025Review
- Biomarkers of intestinal permeability are associated with inflammation in metabolically healthy obesity but not normal-weight obesity.American journal of physiology. Heart and circulatory physiology · 2024Article
- Gestational Diabetes Mellitus-Induced Inflammation in the Placenta via IL-1β and Toll-like Receptor Pathways.International journal of molecular sciences · 2024Article
- The Role of the Gut Microbiota in Complications among Hemodialysis Patients.Microorganisms · 2024Review
14 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The role of chronic inflammation in the pathogenesis of type 2 diabetes mellitus and associated complications is now well established. Therapeutic interventions counteracting metabolic inflammation improve insulin secretion and action and glucose control and may prevent long-term complications. Thus, a number of anti-inflammatory drugs approved for the treatment of other inflammatory conditions are evaluated in patients with metabolic syndrome. Most advanced are clinical studies with IL-1 antagonists showing improved β-cell function and glycemia and prevention of cardiovascular diseases and heart failure. However, alternative anti-inflammatory treatments, alone or in combinations, may turn out to be more effective, depending on genetic predispositions, duration, and manifestation of the disease. Thus, there is a great need for comprehensive and well-designed clinical studies to implement anti-inflammatory drugs in the treatment of patients with metabolic syndrome and its associated conditions.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.