Evidence map›Paper›PMID 31127506›Full record

ArticleChinese journal of integrative medicine2019

Celastrus orbiculatus Extracts Inhibit Human Hepatocellular Carcinoma Growth by Targeting mTOR Signaling Pathways.

Ya-Yun Qian, Wen-Yuan Li, Yan Yan, Xue-Yu Zhao, Ting Yang, Chuan-Ci Fang, Jing-Jing Hou, Yan-Qing Liu

Abstract read
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Article in Chinese journal of integrative medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Ya-Yun QianInstitute of Traditional Chinese Medicine and Western Medicine, School of Medicine, Yangzhou University, Yangzhou, 225009, Jiangsu Province, China. yyqian@yzu.edu.cn.
Wen-Yuan LiInstitute of Traditional Chinese Medicine and Western Medicine, School of Medicine, Yangzhou University, Yangzhou, 225009, Jiangsu Province, China.
Yan YanInstitute of Traditional Chinese Medicine and Western Medicine, School of Medicine, Yangzhou University, Yangzhou, 225009, Jiangsu Province, China.
Xue-Yu ZhaoInstitute of Traditional Chinese Medicine and Western Medicine, School of Medicine, Yangzhou University, Yangzhou, 225009, Jiangsu Province, China.
Ting YangInstitute of Traditional Chinese Medicine and Western Medicine, School of Medicine, Yangzhou University, Yangzhou, 225009, Jiangsu Province, China.
Chuan-Ci FangInstitute of Traditional Chinese Medicine and Western Medicine, School of Medicine, Yangzhou University, Yangzhou, 225009, Jiangsu Province, China.
Jing-Jing HouInstitute of Traditional Chinese Medicine and Western Medicine, School of Medicine, Yangzhou University, Yangzhou, 225009, Jiangsu Province, China.
Yan-Qing LiuInstitute of Traditional Chinese Medicine and Western Medicine, School of Medicine, Yangzhou University, Yangzhou, 225009, Jiangsu Province, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo characterize the molecular mechanism underlying the antineoplastic activity of Celastrus orbiculatus Thunb. extracts (COE).

methodsThe human hepatocellular carcinoma HepG2 cells with mammalian target of rapamycin (mTOR) knockdown expressed (HepG2/mTOR) were constructed using molecular biological technology. In vitro, the HepG2/mTOR

resultsCOE inhibited the proliferation significantly in a concentration-dependent manner in HepG2/mTOR

conclusionCOE was a potential chemotherapeutic drug in HCC treatments via targeting mTOR signal pathway.

Indexed as

AnimalsAntineoplastic Agents, PhytogenicApoptosisCarcinoma, HepatocellularCelastrusCell ProliferationCell SurvivalDown-RegulationFemaleGene Expression Regulation, NeoplasticHep G2 CellsHumansLiver NeoplasmsMiceMice, NudePlant ExtractsAntineoplastic Agents, PhytogenicMTOR protein, humanPlant ExtractsTOR Serine-Threonine KinasesapoptosisCelastrus orbiculatushepatocellular carcinomamammalian target of rapamycin

Identifiers

PMID31127506

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.