ArticleEuropean journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology2019
Detection of Methanobrevibacter smithii in vaginal samples collected from women diagnosed with bacterial vaginosis.
Article in European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 37 citations in OpenAlex.
- Methanobrevibacter smithii activates immune microenvironment of intestinum tenue in a mouse model.Archives of microbiology · 2026Article
- Methanobrevibacter smithii strain U29 whole genome sequence delineates M. smithii intermediate cell variants.BMC research notes · 2025Article
- Exploring the human archaeome: its relevance for health and disease, and its complex interplay with the human immune system.The FEBS journal · 2025Review
- Review
- Archaea in the Human Microbiome and Potential Effects on Human Infectious Disease.Emerging infectious diseases · 2024Review
- The discovery ofiScience · 2024Article
- Human associated Archaea: a neglected microbiome worth investigating.World journal of microbiology & biotechnology · 2024Review
- Holistic View and Novel Perspective on Ruminal and Extra-Gastrointestinal Methanogens in Cattle.Microorganisms · 2023Review
- The evolving role of methanogenic archaea in mammalian microbiomes.Frontiers in microbiology · 2023Review
- Bacteria and Methanogens in the Human Microbiome: a Review of Syntrophic Interactions.Microbial ecology · 2022Review
- Virome and metagenomic analysis reveal the distinct distribution of microbiota in human fetal gut during gestation.Frontiers in immunology · 2022Article
- Introducing clinical nanorachaeaology: Isolation by co-culture ofCurrent research in microbial sciences · 2022Article
- MeconialCurrent research in microbial sciences · 2021Article
- The Mammalian Metaorganism: A Holistic View on How Microbes of All Kingdoms and Niches Shape Local and Systemic Immunity.Frontiers in immunology · 2021Review
- Diversity of Methanogens in Animals' Gut.Microorganisms · 2020Article
- State of the Art in the Culture of the Human Microbiota: New Interests and Strategies.Clinical microbiology reviews · 2020Review
- Detection ofMicroorganisms · 2020Article
- The host-associated archaeome.Nature reviews. Microbiology · 2020Review
- Loss of microbial diversity and pathogen domination of the gut microbiota in critically ill patients.Microbial genomics · 2019Article
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Vaginosis is a dysbiotic condition of the vaginal cavity that has deleterious effects during pregnancy. The role of methanogens in this disease is unknown since current methods of investigation are not appropriate for the search of methanogens. We prospectively investigated the presence of methanogens in vaginal specimens collected from 33 women thereafter diagnosed with bacterial vaginosis and 92 women thereafter diagnosed without bacterial vaginosis (control group) by direct microscopic examination and fluorescent in situ hybridization, PCR-sequencing, and real-time PCR and isolation and culture. These investigations found only one methanogen, Methanobrevibacter smithii, exclusively in 97% bacterial vaginosis specimens and in two intermediate microbiota specimens. M. smithii was detected microscopically in 2/20 specimens analyzed, by PCR-based observations in 34/125 specimens with 99% sequence similarity with the reference 16S rRNA and mcrA gene sequences and was cultured in 9/40 specimens. These data suggest that the detection of M. smithii could be used as a biomarker for the laboratory diagnosis of bacterial vaginosis.
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