Evidence map›Paper›PMID 31127443›Full record

ArticleDigestive diseases and sciences2019

Involvement of Potassium Channels, Nitric Oxide Synthase, and Guanylate Cyclase in the Spasmolytic Effect of Simaba ferruginea A.St.-Hil on Rat Isolated Ileum.

Rafael B Almendra, Oscar C da Fonseca, Daniel B Nunes, Tayane Izabely N da Silva, Jéssica Sara de S M Oliveira, Mariana Helena Chaves, Aldeídia P de Oliveira, Rosimeire F Dos Santos, Rita de Cássia M Oliveira

Abstract read
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In one paragraph

Article in Digestive diseases and sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Rafael B AlmendraMedicinal Plants Research Center (NPPM), Health Sciences Center, Federal University of Piaui, Nossa Senhora de Fátima Avenue, Teresina, PI, 64049-550, Brazil.
Oscar C da FonsecaMedicinal Plants Research Center (NPPM), Health Sciences Center, Federal University of Piaui, Nossa Senhora de Fátima Avenue, Teresina, PI, 64049-550, Brazil.
Daniel B NunesMedicinal Plants Research Center (NPPM), Health Sciences Center, Federal University of Piaui, Nossa Senhora de Fátima Avenue, Teresina, PI, 64049-550, Brazil.
Tayane Izabely N da SilvaMedicinal Plants Research Center (NPPM), Health Sciences Center, Federal University of Piaui, Nossa Senhora de Fátima Avenue, Teresina, PI, 64049-550, Brazil.
Jéssica Sara de S M OliveiraDepartment of Chemistry, Center of Natural Sciences, Federal University of Piaui, Teresina, PI, Brazil.
Mariana Helena ChavesDepartment of Chemistry, Center of Natural Sciences, Federal University of Piaui, Teresina, PI, Brazil.
Aldeídia P de OliveiraMedicinal Plants Research Center (NPPM), Health Sciences Center, Federal University of Piaui, Nossa Senhora de Fátima Avenue, Teresina, PI, 64049-550, Brazil.
Rosimeire F Dos SantosMedicinal Plants Research Center (NPPM), Health Sciences Center, Federal University of Piaui, Nossa Senhora de Fátima Avenue, Teresina, PI, 64049-550, Brazil.
Rita de Cássia M OliveiraMedicinal Plants Research Center (NPPM), Health Sciences Center, Federal University of Piaui, Nossa Senhora de Fátima Avenue, Teresina, PI, 64049-550, Brazil. menesesoliveira@gmail.com.
Universidade Federal do Piauí · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND AND

aimSimaba ferruginea A.St.-Hil. Popularly known as "calunga," is a typical Brazilian cerrado plant whose rhizomes are popular for treating diarrhea.

aimsThe aim of this study was to evaluate the spasmolytic activity and the antidiarrheal effect of the ethanolic extract obtained from S. ferruginea (Sf-EtOH).

methodsIleal segments (1-2 cm) from male Wistar rats were mounted in isolated organ baths and connected to a force transducer, and then to an amplifier which was connected to a computer (AVS Projetos/São Paulo-SP). After stabilization for 60 min, under tension (1 gf), two submaximal contractions were induced with KCl 40 mM or carbachol 10

resultsSf-EtOH promotes relaxation on rat isolated ileum pre-contracted with CCh and KCl in a concentration-dependent manner. Sf-EtOH also inhibited ileum contractions against cumulative concentrations of carbachol (CCh), KCl, and CaCl

conclusionsSf-EtOH acts in a concentration-dependent manner, involving the positive modulation of K

Indexed as

SimaroubaceaeAnimalsDose-Response Relationship, DrugGuanylate CyclaseIleumMaleMuscle Relaxants, CentralNitric Oxide SynthaseOrgan Culture TechniquesParasympatholyticsPlant ExtractsPlant LeavesPotassium ChannelsRatsRats, WistarGuanylate CyclaseMuscle Relaxants, CentralNitric Oxide SynthaseParasympatholyticsPlant ExtractsPotassium ChannelsMedicinal plantsNitric oxidePotassium channelsRat ileum

Identifiers

PMID31127443
OpenAlexW2945716773

What OpenQuestion holds

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Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.