Evidence map›Paper›PMID 31127390›Full record

ArticleAMB Express2019

Genomic insights into a robust gamma-aminobutyric acid-producer Lactobacillus brevis CD0817.

Dandan Gao, Kunpeng Chang, Gongtao Ding, Hongjing Wu, Yuanhong Chen, Mengya Jia, Xiaohua Liu, Shuixing Wang, Yuyuan Jin, Hao Pan and 1 more

Abstract read
In one paragraph

Article in AMB Express, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Isolation and genetic analysis of anBiochemistry and biophysics reports · 2026
    Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. NBiochemical genetics · 2025
    Article
  8. Article
  9. A Novel GABA-ProducingBiomolecules · 2025
    Article
  10. Article
  11. Uracil walking primer PCR: An accurate and efficient genome-walking tool.Journal, genetic engineering & biotechnology · 2025
    Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Review
  17. Article
  18. Article
  19. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Dandan GaoBiomedical Research Center, College of Life Sciences and Engineering, Northwest Minzu University, Lanzhou, 730030, Gansu, People's Republic of China.
Kunpeng ChangState Key Laboratory of Food Science and Technology, Nanchang University, Nanchang, 330047, Jiangxi, People's Republic of China.
Gongtao DingBiomedical Research Center, College of Life Sciences and Engineering, Northwest Minzu University, Lanzhou, 730030, Gansu, People's Republic of China.
Hongjing WuNanchang University College of Science and Technology, Nanchang, 330029, Jiangxi, People's Republic of China.
Yuanhong ChenState Key Laboratory of Food Science and Technology, Nanchang University, Nanchang, 330047, Jiangxi, People's Republic of China.
Mengya JiaState Key Laboratory of Food Science and Technology, Nanchang University, Nanchang, 330047, Jiangxi, People's Republic of China.
Xiaohua LiuSino-German Joint Research Institute, Nanchang University, Nanchang, 330047, Jiangxi, People's Republic of China.
Shuixing WangSino-German Joint Research Institute, Nanchang University, Nanchang, 330047, Jiangxi, People's Republic of China.
Yuyuan JinSino-German Joint Research Institute, Nanchang University, Nanchang, 330047, Jiangxi, People's Republic of China.
Hao PanSino-German Joint Research Institute, Nanchang University, Nanchang, 330047, Jiangxi, People's Republic of China.
Haixing LiBiomedical Research Center, College of Life Sciences and Engineering, Northwest Minzu University, Lanzhou, 730030, Gansu, People's Republic of China. hxli@ncu.edu.cn.

Funding

Fundamental Research Funds for the Central Universities of Northwest Minzu University 31920190023Jiangxi Provincial Department of Science and Technology 20153BCB23034Jiangxi Provincial Department of Science and Technology 20171BAB204002National Natural Science Foundation of China 21566023National Natural Science Foundation of China 31570070
6 · The paper itself

Abstract

Lactobacillus brevis CD0817, a strain isolated from a healthy adult gut, was currently the most efficient lactic acid bacterial cell factory for gamma-aminobutyric acid. In this study, the complete genome sequence of CD0817 was determined and compared with some related L. brevis genomes. The CD0817 genome consists of one 2,990,570-bp chromosome and four plasmids. The comparative genomic and phylogenetic analysis revealed that L. brevis CD0817 was not very conserved with low GABA-producing L. brevis strains. A significant divergence was that CD0817 harbors only the gadCA operon whereas the low GABA-producing L. brevis strains contain the operon and gadB. The gadB seemed to only marginally contribute to the accumulation of GABA. The high GABA production ability of CD0817 may be associated with its extraordinary genome.

Indexed as

Comparative genomics analysisComplete genome sequenceGamma-aminobutyric acidGlutamic acid decarboxylaseLactobacillus brevis CD0817

Identifiers

PMID31127390
PMCPMC6534642

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.