Evidence map›Paper›PMID 31127295›Full record

ArticleHuman molecular genetics2019

A multi-ancestry genome-wide study incorporating gene-smoking interactions identifies multiple new loci for pulse pressure and mean arterial pressure.

Yun Ju Sung, Lisa de las Fuentes, Thomas W Winkler, Daniel I Chasman, Amy R Bentley, Aldi T Kraja, Ioanna Ntalla, Helen R Warren, Xiuqing Guo, Karen Schwander and 272 more

Open access · bronzeAbstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Human molecular genetics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed, 4 pooled it
4.8field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 4 syntheses or guidelines pooled it, 47 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Integrative Genomic Analyses IdentifybioRxiv : the preprint server for biology · 2026
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  14. Genes, environment, and African ancestry in cardiometabolic disorders.Trends in endocrinology and metabolism: TEM · 2023
    Review
  15. Review
  16. Review
  17. Gene-lifestyle interactions in the genomics of human complex traits.European journal of human genetics : EJHG · 2022
    Article
  18. Article
  19. Article
  20. Gene-Environment Interactions for Cardiovascular Disease.Current atherosclerosis reports · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

282 authors at 20 institutions in 24 countries.

Yun Ju SungDivision of Biostatistics, Washington University School of Medicine, St. Louis, MO, USA.
Lisa de las FuentesDivision of Biostatistics, Washington University School of Medicine, St. Louis, MO, USA.
Thomas W WinklerDepartment of Genetic Epidemiology, University of Regensburg, Regensburg, Germany.
Daniel I ChasmanPreventive Medicine, Brigham and Women's Hospital, Boston, MA, USA.
Amy R BentleyCenter for Research on Genomics and Global Health, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.
Aldi T KrajaDivision of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, MO, USA.
Ioanna NtallaClinical Pharmacology, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
Helen R WarrenClinical Pharmacology, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
Xiuqing GuoDivision of Genomic Outcomes, Department of Pediatrics, The Institute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA, USA.
Karen SchwanderDivision of Biostatistics, Washington University School of Medicine, St. Louis, MO, USA.
Alisa K ManningCenter for Human Genetics Research, Massachusetts General Hospital, Boston, MA, USA.
Michael R BrownHuman Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX, USA.
Hugues AschardDepartment of Epidemiology, Harvard School of Public Health, Boston, MA, USA.
Mary F FeitosaDivision of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, MO, USA.
Nora FranceschiniEpidemiology, University of North Carolina Gillings School of Global Public Health, Chapel Hill, NC, USA.
Yingchang LuIcahn School of Medicine at Mount Sinai, The Charles Bronfman Institute for Personalized Medicine, New York, NY, USA.
Ching-Yu ChengSingapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore.
Xueling SimSaw Swee Hock School of Public Health, National University Health System and National University of Singapore, Singapore, Singapore.
Dina VojinovicDepartment of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands.
Jonathan MartenMedical Research Council Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK.
Solomon K MusaniJackson Heart Study, Department of Medicine, University of Mississippi Medical Center, Jackson, MS, USA.
Tuomas O KilpeläinenNovo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Melissa A RichardBrown Foundation Institute of Molecular Medicine, The University of Texas Health Science Center at Houston, Houston, TX, USA.
Stella AslibekyanDepartment of Epidemiology, University of Alabama at Birmingham, Birmingham, AL, USA.
Traci M BartzCardiovascular Health Research Unit, Biostatistics and Medicine, University of Washington, Seattle, WA, USA.
Rajkumar DorajooGenome Institute of Singapore, Agency for Science Technology and Research, Singapore, Singapore.
Changwei LiEpidemiology and Biostatistics, University of Georgia at Athens College of Public Health, Athens, GA, USA.
Yongmei LiuPublic Health Sciences, Epidemiology and Prevention, Wake Forest University Health Sciences, Winston-Salem, NC, USA.
Tuomo RankinenHuman Genomics Laboratory, Pennington Biomedical Research Center, Baton Rouge, LA, USA.
Albert Vernon SmithIcelandic Heart Association, Kopavogur, Iceland.
Salman M TajuddinHealth Disparities Research Section, Laboratory of Epidemiology and Population Sciences, National Institute on Aging, National Institutes of Health, Baltimore, MD, USA.
Bamidele O TayoDepartment of Public Health Sciences, Loyola University Chicago, Maywood, IL, USA.
Wei ZhaoDepartment of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA.
Yanhua ZhouBiostatistics, Boston University School of Public Health, Boston, MA, USA.
Nana MatobaLaboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.
Tamar SoferDepartment of Medicine, Harvard Medical School, Boston, MA, USA.
Maris AlverEstonian Genome Center, Institute of Genomics, University of Tartu, Tartu, Estonia.
Marzyeh AminiDepartment of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen RB, The Netherlands.
Mathilde BoisselCNRS UMR 8199, European Genomic Institute for Diabetes (EGID), Institut Pasteur de Lille, University of Lille, Lille, France.
Jin Fang ChaiSaw Swee Hock School of Public Health, National University Health System and National University of Singapore, Singapore, Singapore.
Xu ChenDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Stockholm, Sweden.
Jasmin DiversBiostatistical Sciences, Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, NC, USA.
Ilaria GandinDepartment of Medical Sciences, University of Trieste, Trieste, Italy.
Chuan GaoMolecular Genetics and Genomics Program, Wake Forest School of Medicine, Winston-Salem, NC, USA.
Franco GiulianiniPreventive Medicine, Brigham and Women's Hospital, Boston, MA, USA.
Anuj GoelDivision of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, Oxfordshire, UK.
Sarah E HarrisCentre for Cognitive Ageing and Cognitive Epidemiology, The University of Edinburgh, Edinburgh, UK.
Fernando P HartwigPostgraduate Programme in Epidemiology, Federal University of Pelotas, Pelotas, RS, Brazil.
Meian HeLab Genetics and Molecular Cardiology, Cardiology, Heart Institute, University of Sao Paulo, Sao Paulo, CA, USA.
Andrea R V R HorimotoDepartment of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA.
Fang-Chi HsuBiostatistical Sciences, Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, NC, USA.
Anne U JacksonDepartment of Human Genetics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA.
Candace M KammererDepartment of Public Health, Faculty of Medicine, University of Kelaniya, Ragama, Sri Lanka.
Anuradhani KasturiratneFoundation for Research in Health Exercise and Nutrition, Kuopio Research Institute of Exercise Medicine, Kuopio, Finland.
Pirjo KomulainenResearch Unit of Molecular Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.
Brigitte KühnelInstitute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.
Karin LeanderMedical Research, Taichung Veterans General Hospital, Department of Social Work, Tunghai University, Taichung, Taiwan.
Wen-Jane LeeOphthalmology, Taichung Veterans General Hospital, Taichung, Taiwan.
Keng-Hung LinMRC Epidemiology Unit, University of Cambridge, Cambridge, UK.
Jian'an LuanDepartment of Clinical Chemistry, Fimlab Laboratories, Tampere, Finland.
Leo-Pekka LyytikäinenDepartment of Clinical Chemistry, Finnish Cardiovascular Research Center-Tampere, Faculty of Medicine and Life Sciences, University of Tampere, Tampere, Finland.
Colin A McKenzieSchool of Public Health, Department of Occupational and Environmental Health and State Key Laboratory of Environmental Health for Incubating, Tongi Medical College, Huazhong University of Science and Technology, Wuhan, China.
Christopher P NelsonDepartment of Cardiovascular Sciences, University of Leicester, Leicester, UK.
Raymond NoordamInternal Medicine, Gerontology and Geriatrics, Leiden University Medical Center, Leiden, The Netherlands.
Robert A ScottDepartment of Clinical Chemistry, Fimlab Laboratories, Tampere, Finland.
Wayne H H SheuEndocrinology and Metabolism, Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan.
Alena StančákováInstitute of Clinical Medicine, Internal Medicine, University of Eastern Finland, Kuopio, Finland.
Fumihiko TakeuchiDepartment of Gene Diagnostics and Therapeutics, Research Institute, National Center for Global Health and Medicine, Tokyo, Japan.
Peter J van der MostDepartment of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen RB, The Netherlands.
Tibor V VargaDepartment of Clinical Sciences, Genetic and Molecular Epidemiology Unit, Lund University Diabetes Centre, Skåne University Hospital, Malmö, Sweden.
Robert J WakenDivision of Biostatistics, Washington University School of Medicine, St. Louis, MO, USA.
Heming WangDepartment of Medicine, Harvard Medical School, Boston, MA, USA.
Yajuan WangDepartment of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, OH, USA.
Erin B WareDepartment of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA.
Stefan WeissInterfaculty Institute for Genetics and Functional Genomics, University Medicine Ernst Moritz Arndt University Greifswald, Greifswald, Germany.
Wanqing WenDivision of Epidemiology, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN, USA.
Lisa R YanekGeneral Internal Medicine, GeneSTAR Research Program, Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Weihua ZhangMRC-PHE Centre for Environment and Health, Department of Epidemiology and Biostatistics, Imperial College London, London, UK.
Jing Hua ZhaoDepartment of Clinical Chemistry, Fimlab Laboratories, Tampere, Finland.
Saima AfaqMRC-PHE Centre for Environment and Health, Department of Epidemiology and Biostatistics, Imperial College London, London, UK.
Tamuno AlfredIcahn School of Medicine at Mount Sinai, The Charles Bronfman Institute for Personalized Medicine, New York, NY, USA.
Najaf AminDepartment of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands.
Dan E ArkingMcKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Tin AungSingapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore.
R Graham BarrDepartments of Medicine and Epidemiology, Columbia University Medical Center, New York, NY, USA.
Lawrence F BielakDepartment of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA.
Eric BoerwinkleHuman Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX, USA.
Erwin P BottingerIcahn School of Medicine at Mount Sinai, The Charles Bronfman Institute for Personalized Medicine, New York, NY, USA.
Peter S BraundDepartment of Cardiovascular Sciences, University of Leicester, Leicester, UK.
Jennifer A BrodyCardiovascular Health Research Unit, Medicine, University of Washington, Seattle, WA, USA.
Ulrich BroeckelSection of Genomic Pediatrics, Department of Pediatrics, Medicine and Physiology, Medical College of Wisconsin, Milwaukee, WI, USA.
Brian CadeDivision of Sleep and Circadian Disorders, Brigham and Women's Hospital, Boston, MA, USA.
Archie CampbellCentre for Genomic & Experimental Medicine, Institute of Genetics & Molecular Medicine, University of Edinburgh, Edinburgh, UK.
Mickaël CanouilCNRS UMR 8199, European Genomic Institute for Diabetes (EGID), Institut Pasteur de Lille, University of Lille, Lille, France.
Aravinda ChakravartiMcKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Massimiliano CoccaDepartment of Medical Sciences, University of Trieste, Trieste, Italy.
Francis S CollinsMedical Genomics and Metabolic Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.
John M ConnellNinewells Hospital & Medical School, University of Dundee, Dundee, Scotland, UK.
Renée de MutsertClinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands.
H Janaka de SilvaDepartment of Medicine, Faculty of Medicine, University of Kelaniya, Ragama, Sri Lanka.
Marcus DörrDZHK (German Centre for Cardiovascular Health), Partner Site Greifswald, Greifswald, Germany.
Qing DuanDepartment of Genetics, University of North Carolina, Chapel Hill, USA.
Charles B EatonDepartment of Family Medicine and Epidemiology, Alpert Medical School of Brown University, Providence, RI, USA.
Georg EhretMcKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Evangelos EvangelouMRC-PHE Centre for Environment and Health, Department of Epidemiology and Biostatistics, Imperial College London, London, UK.
Jessica D FaulSurvey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI, USA.
Nita G ForouhiDepartment of Clinical Chemistry, Fimlab Laboratories, Tampere, Finland.
Oscar H FrancoDepartment of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands.
Yechiel FriedlanderBraun School of Public Health, Hebrew University-Hadassah Medical Center, Jerusalem, Israel.
He GaoMRC-PHE Centre for Environment and Health, Department of Epidemiology and Biostatistics, Imperial College London, London, UK.
Bruna GiganteMedical Research, Taichung Veterans General Hospital, Department of Social Work, Tunghai University, Taichung, Taiwan.
C Charles GuDivision of Biostatistics, Washington University School of Medicine, St. Louis, MO, USA.
Preeti GuptaSingapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore.
Saskia P HagenaarsCentre for Cognitive Ageing and Cognitive Epidemiology, The University of Edinburgh, Edinburgh, UK.
Tamara B HarrisLaboratory of Epidemiology and Population Sciences, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA.
Jiang HeEpidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA, USA.
Sami HeikkinenInstitute of Clinical Medicine, Internal Medicine, University of Eastern Finland, Kuopio, Finland.
Chew-Kiat HengDepartment of Paediatrics, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.
Albert HofmanDepartment of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands.
Barbara V HowardMedStar Health Research Institute, Hyattsville, MD, USA.
Steven C HuntDivision of Epidemiology, Department of Internal Medicine, University of Utah School of Medicine, Salt Lake City, UT, USA.
Marguerite R IrvinDepartment of Biostatistics, University of Alabama at Birmingham, Birmingham, AL, USA.
Yucheng JiaDivision of Genomic Outcomes, Department of Pediatrics, The Institute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA, USA.
Tomohiro KatsuyaDepartment of Clinical Gene Therapy, Osaka University Graduate School of Medicine, Suita, Japan.
Joel KaufmanEpidemiology, Occupational and Environmental Medicine Program, University of Washington, Seattle, WA, USA.
Nicola D KerrisonDepartment of Clinical Chemistry, Fimlab Laboratories, Tampere, Finland.
Chiea Chuen KhorGenome Institute of Singapore, Agency for Science Technology and Research, Singapore, Singapore.
Woon-Puay KohSaw Swee Hock School of Public Health, National University Health System and National University of Singapore, Singapore, Singapore.
Heikki A KoistinenDepartment of Public Health Solutions, National Institute for Health and Welfare, Helsinki, Finland.
Charles B KooperbergFred Hutchinson Cancer Research Center, University of Washington School of Public Health, Seattle, WA, USA.
Jose E KriegerDepartment of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA.
Michiaki KuboRIKEN Center for Integrative Medical Sciences, Yokohama, Japan.
Zoltan KutalikInstitute of Social Preventive Medicine, Lausanne University Hospital, Lausanne, Switzerland.
Johanna KuusistoInstitute of Clinical Medicine, Internal Medicine, University of Eastern Finland, Kuopio, Finland.
Timo A LakkaResearch Unit of Molecular Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.
Carl D LangefeldBiostatistical Sciences, Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, NC, USA.
Claudia LangenbergDepartment of Clinical Chemistry, Fimlab Laboratories, Tampere, Finland.
Lenore J LaunerLaboratory of Epidemiology and Population Sciences, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA.
Joseph H LeeSergievsky Center, College of Physicians and Surgeons, Columbia University Mailman School of Public Health, New York, NY, USA.
Benjamin LehneMRC-PHE Centre for Environment and Health, Department of Epidemiology and Biostatistics, Imperial College London, London, UK.
Daniel LevyNHLBI Framingham Heart Study, Framingham, MA, USA.
Cora E LewisDepartment of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.
Yize LiDivision of Biostatistics, Washington University School of Medicine, St. Louis, MO, USA.
Lifelines Cohort Study
Sing Hui LimSingapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore.
Ching-Ti LiuBiostatistics, Boston University School of Public Health, Boston, MA, USA.
Jianjun LiuSaw Swee Hock School of Public Health, National University Health System and National University of Singapore, Singapore, Singapore.
Jingmin LiuWHI CCC, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
Yeheng LiuDivision of Genomic Outcomes, Department of Pediatrics, The Institute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA, USA.
Marie LohMRC-PHE Centre for Environment and Health, Department of Epidemiology and Biostatistics, Imperial College London, London, UK.
Kurt K LohmanBiostatistical Sciences, Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, NC, USA.
Tin LouieDepartment of Biostatistics, University of Washington, Seattle, WA, USA.
Reedik MägiEstonian Genome Center, Institute of Genomics, University of Tartu, Tartu, Estonia.
Koichi MatsudaLaboratory for Clinical Genome Sequencing, Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, The University of Tokyo, Minato-ku, Japan.
Thomas MeitingerInstitute of Human Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.
Andres MetspaluEstonian Genome Center, Institute of Genomics, University of Tartu, Tartu, Estonia.
Lili MilaniCardiovascular Division, Department of Medicine, Washington University, St. Louis, MO, USA.
Yukihide MomozawaLaboratory for Genotyping Development, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.
Thomas H MosleyGeriatrics, Medicine, University of Mississippi, Jackson, MS, USA.
Mike A NallsLaboratory of Neurogenetics, National Institute on Aging, Bethesda, MD, USA.
Ubaydah NasriDivision of Genomic Outcomes, Department of Pediatrics, The Institute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA, USA.
Jeff R O'ConnellDivision of Endocrinology, Diabetes, and Nutrition, University of Maryland School of Medicine, Baltimore, MD, USA.
Adesola OgunniyiDepartment of Medicine, University of Ibadan, Ibadan, Nigeria.
Walter R PalmasInternal Medicine, Columbia University, New York, NY, USA.
Nicholette D PalmerBiochemistry, Wake Forest School of Medicine, Winston-Salem, NC, USA.
James S PankowDivision of Epidemiology and Community Health, University of Minnesota School of Public Health, Minneapolis, MN, USA.
Nancy L PedersenDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Stockholm, Sweden.
Annette PetersInstitute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.
Patricia A PeyserDepartment of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA.
Ozren PolasekDepartment of Public Health, Department of Medicine, University of Split, Split, Croatia.
David PorteousCentre for Genomic & Experimental Medicine, Institute of Genetics & Molecular Medicine, University of Edinburgh, Edinburgh, UK.
Olli T RaitakariDepartment of Clinical Physiology and Nuclear Medicine, Turku University Hospital, Turku, Finland.
Frida RenströmDepartment of Clinical Sciences, Genetic and Molecular Epidemiology Unit, Lund University Diabetes Centre, Skåne University Hospital, Malmö, Sweden.
Treva K RiceDivision of Biostatistics, Washington University School of Medicine, St. Louis, MO, USA.
Paul M RidkerPreventive Medicine, Brigham and Women's Hospital, Boston, MA, USA.
Antonietta RobinoInstitute for Maternal and Child Health-IRCCS 'Burlo Garofolo', Trieste, Italy.
Jennifer G RobinsonDepartment of Epidemiology and Medicine, University of Iowa, Iowa City, IA, USA.
Lynda M RosePreventive Medicine, Brigham and Women's Hospital, Boston, MA, USA.
Igor RudanCentre for Global Health Research, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, UK.
Charumathi SabanayagamSingapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore.
Babatunde L SalakoDepartment of Medicine, University of Ibadan, Ibadan, Nigeria.
Kevin SandowDivision of Genomic Outcomes, Department of Pediatrics, The Institute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA, USA.
Carsten O SchmidtDZHK (German Centre for Cardiovascular Health), Partner Site Greifswald, Greifswald, Germany.
Pamela J SchreinerDivision of Epidemiology and Community Health, University of Minnesota School of Public Health, Minneapolis, MN, USA.
William R ScottMRC-PHE Centre for Environment and Health, Department of Epidemiology and Biostatistics, Imperial College London, London, UK.
Peter SeverInternational Centre for Circulatory Health, Imperial College London, London, UK.
Mario SimsJackson Heart Study, Department of Medicine, University of Mississippi Medical Center, Jackson, MS, USA.
Colleen M SitlaniCardiovascular Health Research Unit, Medicine, University of Washington, Seattle, WA, USA.
Blair H SmithDivision of Population Health Sciences, Ninewells Hospital and Medical School, University of Dundee, Dundee, UK.
Jennifer A SmithDepartment of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA.
Harold SniederDepartment of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen RB, The Netherlands.
John M StarrCentre for Cognitive Ageing and Cognitive Epidemiology, The University of Edinburgh, Edinburgh, UK.
Konstantin StrauchInstitute of Genetic Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.
Hua TangDepartment of Genetics, Stanford University, Stanford, CA, USA.
Kent D TaylorDivision of Genomic Outcomes, Department of Pediatrics, The Institute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA, USA.
Yik Ying TeoSaw Swee Hock School of Public Health, National University Health System and National University of Singapore, Singapore, Singapore.
Yih Chung ThamSingapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore.
André G UitterlindenDepartment of Internal Medicine, Erasmus University Medical Center, Rotterdam, The Netherlands.
Melanie WaldenbergerResearch Unit of Molecular Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.
Lihua WangDivision of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, MO, USA.
Ya Xing WangBeijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Ophthalmology and Visual Science Key Lab, Beijing Tongren Hospital, Capital Medical University, Beijing, China.
Wen Bin WeiBeijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing, China.
Gregory WilsonJackson Heart Study, School of Public Health, Jackson State University, Jackson, MS, USA.
Mary K WojczynskiDivision of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, MO, USA.
Yong-Bing XiangState Key Laboratory of Oncogene and Related Genes & Department of Epidemiology, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, P.R. China.
Jie YaoDivision of Genomic Outcomes, Department of Pediatrics, The Institute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA, USA.
Jian-Min YuanDepartment of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA.
Alan B ZondermanBehavioral Epidemiology Section, Laboratory of Epidemiology and Population Sciences, National Institute on Aging, National Institutes of Health, Baltimore, MD, USA.
Diane M BeckerGeneral Internal Medicine, GeneSTAR Research Program, Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Michael BoehnkeDepartment of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA.
Donald W BowdenBiochemistry, Wake Forest School of Medicine, Winston-Salem, NC, USA.
John C ChambersMRC-PHE Centre for Environment and Health, Department of Epidemiology and Biostatistics, Imperial College London, London, UK.
Yii-Der Ida ChenDivision of Genomic Outcomes, Department of Pediatrics, The Institute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA, USA.
David R WeirSurvey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI, USA.
Ulf de FaireInstitute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
Ian J DearyCentre for Cognitive Ageing and Cognitive Epidemiology, The University of Edinburgh, Edinburgh, UK.
Tõnu EskoEstonian Genome Center, Institute of Genomics, University of Tartu, Tartu, Estonia.
Martin FarrallDivision of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, Oxfordshire, UK.
Terrence ForresterTropical Metabolism Research Unit, Tropical Medicine Research Institute, University of the West Indies, Mona, Jamaica.
Barry I FreedmanNephrology, Internal Medicine, Wake Forest School of Medicine, Winston-Salem, NC, USA.
Philippe FroguelCNRS UMR 8199, European Genomic Institute for Diabetes (EGID), Institut Pasteur de Lille, University of Lille, Lille, France.
Paolo GaspariniDepartment of Medical Sciences, University of Trieste, Trieste, Italy.
Christian GiegerResearch Unit of Molecular Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.
Bernardo Lessa HortaPostgraduate Programme in Epidemiology, Federal University of Pelotas, Pelotas, RS, Brazil.
Yi-Jen HungEndocrinology and Metabolism, Tri-Service General Hospital, National Defense Medical Center, Taipei City, Taipei, Taiwan.
Jost Bruno JonasBeijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing, China.
Norihiro KatoDepartment of Gene Diagnostics and Therapeutics, Research Institute, National Center for Global Health and Medicine, Tokyo, Japan.
Jaspal S KoonerDepartment of Cardiology, Ealing Hospital, Middlesex, UK.
Markku LaaksoInstitute of Clinical Medicine, Internal Medicine, University of Eastern Finland, Kuopio, Finland.
Terho LehtimäkiDepartment of Clinical Chemistry, Fimlab Laboratories, Tampere, Finland.
Kae-Woei LiangSchool of Medicine, National Yang-ming University, Taipei, Taiwan.
Patrik K E MagnussonDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Stockholm, Sweden.
Albertine J OldehinkelDepartment of Psychiatry, University of Groningen, University Medical Center Groningen, Groningen RB, The Netherlands.
Alexandre C PereiraLab Genetics and Molecular Cardiology, Cardiology, Heart Institute, University of Sao Paulo, Sao Paulo, CA, USA.
Thomas PerlsGeriatrics Section, Boston University Medical Center, Boston, MA, USA.
Rainer RauramaaFoundation for Research in Health Exercise and Nutrition, Kuopio Research Institute of Exercise Medicine, Kuopio, Finland.
Susan RedlineDivision of Sleep and Circadian Disorders, Brigham and Women's Hospital, Boston, MA, USA.
Rainer RettigDZHK (German Centre for Cardiovascular Health), Partner Site Greifswald, Greifswald, Germany.
Nilesh J SamaniDepartment of Cardiovascular Sciences, University of Leicester, Leicester, UK.
James ScottNational Heart and Lung Institute, Imperial College London, London, UK.
Xiao-Ou ShuDivision of Epidemiology, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN, USA.
Pim van der HarstDepartment of Cardiology, University of Groningen, University Medical Center Groningen, Groningen RB, The Netherlands.
Lynne E WagenknechtPublic Health Sciences, Wake Forest School of Medicine, Winston-Salem, NC, USA.
Nicholas J WarehamMRC Epidemiology Unit, University of Cambridge, Cambridge, UK.
Hugh WatkinsDivision of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, Oxfordshire, UK.
Ananda R WickremasingheDepartment of Public Health, Faculty of Medicine, University of Kelaniya, Ragama, Sri Lanka.
Tangchun WuSchool of Public Health, Department of Occupational and Environmental Health and State Key Laboratory of Environmental Health for Incubating, Tongi Medical College, Huazhong University of Science and Technology, Wuhan, China.
Yoichiro KamataniLaboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.
Cathy C LaurieDepartment of Biostatistics, University of Washington, Seattle, WA, USA.
Claude BouchardHuman Genomics Laboratory, Pennington Biomedical Research Center, Baton Rouge, LA, USA.
Richard S CooperDepartment of Public Health Sciences, Loyola University Chicago, Maywood, IL, USA.
Michele K EvansHealth Disparities Research Section, Laboratory of Epidemiology and Population Sciences, National Institute on Aging, National Institutes of Health, Baltimore, MD, USA.
Vilmundur GudnasonIcelandic Heart Association, Kopavogur, Iceland.
James HixsonHuman Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX, USA.
Sharon L R KardiaDepartment of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA.
Stephen B KritchevskyDepartment of Internal Medicine, Section on Gerontology and Geriatric Medicine, Wake Forest School of Medicine, Winston-Salem, NC, USA.
Bruce M PsatyCardiovascular Health Research Unit, Epidemiology, Medicine and Health Services, University of Washington, Seattle, WA, USA.
Rob M van DamSaw Swee Hock School of Public Health, National University Health System and National University of Singapore, Singapore, Singapore.
Donna K ArnettDean's Office, University of Kentucky College of Public Health, Lexington, KY, USA.
Dennis O Mook-KanamoriClinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands.
Myriam FornageBrown Foundation Institute of Molecular Medicine, The University of Texas Health Science Center at Houston, Houston, TX, USA.
Ervin R FoxCardiology, Medicine, University of Mississippi Medical Center, Jackson, MS, USA.
Caroline HaywardMedical Research Council Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK.
Cornelia M van DuijnDepartment of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands.
E Shyong TaiSaw Swee Hock School of Public Health, National University Health System and National University of Singapore, Singapore, Singapore.
Tien Yin WongSingapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore.
Ruth J F LoosIcahn School of Medicine at Mount Sinai, The Charles Bronfman Institute for Personalized Medicine, New York, NY, USA.
Alex P ReinerFred Hutchinson Cancer Research Center, University of Washington School of Public Health, Seattle, WA, USA.
Charles N RotimiCenter for Research on Genomics and Global Health, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.
Laura J BierutDepartment of Psychiatry, Washington University School of Medicine, St. Louis, MO, USA.
Xiaofeng ZhuDepartment of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, OH, USA.
L Adrienne CupplesBiostatistics, Boston University School of Public Health, Boston, MA, USA.
Michael A ProvinceDivision of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, MO, USA.
Jerome I RotterDivision of Genomic Outcomes, Department of Pediatrics, The Institute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA, USA.
Paul W FranksDepartment of Clinical Sciences, Genetic and Molecular Epidemiology Unit, Lund University Diabetes Centre, Skåne University Hospital, Malmö, Sweden.
Kenneth RiceDepartment of Biostatistics, University of Washington, Seattle, WA, USA.
Paul ElliottMRC-PHE Centre for Environment and Health, Department of Epidemiology and Biostatistics, Imperial College London, London, UK.
Mark J CaulfieldClinical Pharmacology, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
W James GaudermanBiostatistics, Preventive Medicine, University of Southern California, Los Angeles, CA, USA.
Patricia B MunroeClinical Pharmacology, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
Dabeeru C RaoDivision of Biostatistics, Washington University School of Medicine, St. Louis, MO, USA.
Alanna C MorrisonHuman Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX, USA.
National Institutes of Health · USUniversity of Michigan · USThe Lundquist Institute · USBrigham and Women's Hospital · USUniversity of Washington · USWashington University in St. Louis · USNational University of Singapore · SGAgency for Science, Technology and Research · SGUniversity Medical Center Groningen · NLBoston University · USFimlab (Finland) · FIJackson Memorial Hospital · USBeijing Tongren Hospital · CNErasmus MC · NLHelmholtz Zentrum München · DEJohns Hopkins University · USUniversity of Eastern Finland · FIWake Forest University · USCentre for Human Genetics · GBCentre National de la Recherche Scientifique · FR

Funding

HRS Yrs29-34: Y33 SSA CoFundingU01AG009740 · NIA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Jessica Faul, KENNETH M LANGA · 1990 to 2026
$555.8M
Genetic epidemiology of complex diseasesZIAHG200362 · NHGRI · NATIONAL HUMAN GENOME RESEARCH INSTITUTE · PI ROTIMI, CHARLES · 2009 to 2025
$54.7M
Framingham Project/LevyZIAHL006001 · NHLBI · NATIONAL HEART, LUNG, AND BLOOD INSTITUTE · PI LEVY, DANIEL · 2009 to 2025
$51.1M
Genetic analysis of type II diabetes in Finnish populationZIAHG000024 · NHGRI · NATIONAL HUMAN GENOME RESEARCH INSTITUTE · PI ERDOS, MICHAEL · 2009 to 2025
$38.2M
Long Life Family Study: Data Management and Coordinating CenterU01AG023746 · NIA · WASHINGTON UNIVERSITY · PI PROVINCE, MICHAEL A. · 2004 to 2018
$29.2M
Genome-Wide Association Analysis in Essential Hypertension (FEHGAS study)R01HL086694 · NHLBI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI ARAVINDA CHAKRAVARTI · 2007 to 2026
$21.2M
The Underlying Biology of Health DisparitiesZIAAG000519 · NIA · NATIONAL INSTITUTE ON AGING · PI EVANS, MICHELE K · 2009 to 2025
$15.7M
Identifying Genes for Type 2 Diabetes: FUSIONU01DK062370 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI BOEHNKE, MICHAEL L, SCOTT, LAURA J. · 2009 to 2021
$11.6M
CHARGE Consortium: Omics Discovery for CVD and Aging PhenotypesR01HL105756 · NHLBI · UNIVERSITY OF WASHINGTON · PI Bruce M Psaty, NICHOLAS L SMITH · 2011 to 2026
$9.5M
Rare variants and NHLBI traits in deeply phenotyped cohortsR01HL120393 · NHLBI · UNIVERSITY OF WASHINGTON · PI PSATY, BRUCE M, RICE, KENNETH M. · 2014 to 2016
$8.9M
A Multi-Ethnic Study of Gene-Lifestyle Interactions in Cardiovascular TraitsR01HL118305 · NHLBI · WASHINGTON UNIVERSITY · PI RAO, DABEERU C · 2014 to 2017
$8.3M
Prospective studies of cancer etiology and prevention in Shanghai and SingaporeR01CA144034 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI YUAN, JIAN-MIN · 2010 to 2014
$7.0M
Biotechnology and Biological Sciences Research Council BB/F019394/1British Heart Foundation FS/12/82/29736Cancer Research UK 14136Medical Research Council G0401527Medical Research Council G0500300Medical Research Council G1000143Medical Research Council G9521010Medical Research Council MC_EX_MR/M009203/1Medical Research Council MC_PC_14089Medical Research Council MC_UP_1605/7Medical Research Council MC_UU_00007/10Medical Research Council MC_UU_12015/1Medical Research Council MR/K002414/1Medical Research Council MR/L01341X/1Medical Research Council MR/M009203/1Medical Research Council MR/N003284/1Medical Research Council MR/R023484/1NCI NIH HHS R01 CA144034NCI NIH HHS UM1 CA182876NHLBI NIH HHS K01 HL135405NHLBI NIH HHS K25 HL121091NHLBI NIH HHS R01 HL086694NHLBI NIH HHS R01 HL103612NHLBI NIH HHS R01 HL105756NHLBI NIH HHS R01 HL118305NHLBI NIH HHS R01 HL119443NHLBI NIH HHS R01 HL120393NHLBI NIH HHS U01 HL120393NHLBI NIH HHS U01 HL130114NIA NIH HHS R01 AG055406NIA NIH HHS R01 AG060110NIA NIH HHS R01 AG067592NIA NIH HHS U01 AG009740NIA NIH HHS U01 AG023746NIDDK NIH HHS R01 DK062370NIDDK NIH HHS T32 DK091317NIDDK NIH HHS U01 DK062370Wellcome Trust 212945/Z/18/Z
6 · The paper itself

Abstract

Elevated blood pressure (BP), a leading cause of global morbidity and mortality, is influenced by both genetic and lifestyle factors. Cigarette smoking is one such lifestyle factor. Across five ancestries, we performed a genome-wide gene-smoking interaction study of mean arterial pressure (MAP) and pulse pressure (PP) in 129 913 individuals in stage 1 and follow-up analysis in 480 178 additional individuals in stage 2. We report here 136 loci significantly associated with MAP and/or PP. Of these, 61 were previously published through main-effect analysis of BP traits, 37 were recently reported by us for systolic BP and/or diastolic BP through gene-smoking interaction analysis and 38 were newly identified (P < 5 × 10-8, false discovery rate < 0.05). We also identified nine new signals near known loci. Of the 136 loci, 8 showed significant interaction with smoking status. They include CSMD1 previously reported for insulin resistance and BP in the spontaneously hypertensive rats. Many of the 38 new loci show biologic plausibility for a role in BP regulation. SLC26A7 encodes a chloride/bicarbonate exchanger expressed in the renal outer medullary collecting duct. AVPR1A is widely expressed, including in vascular smooth muscle cells, kidney, myocardium and brain. FHAD1 is a long non-coding RNA overexpressed in heart failure. TMEM51 was associated with contractile function in cardiomyocytes. CASP9 plays a central role in cardiomyocyte apoptosis. Identified only in African ancestry were 30 novel loci. Our findings highlight the value of multi-ancestry investigations, particularly in studies of interaction with lifestyle factors, where genomic and lifestyle differences may contribute to novel findings.

Indexed as

Gene-Environment InteractionPolymorphism, GeneticAdolescentAdultAgedAged, 80 and overAntiportersArterial PressureBlood PressureCaspase 9EthnicityFemaleGenome-Wide Association StudyHumansHypertensionMaleAntiportersAVPR1A protein, humanCASP9 protein, humanCaspase 9CSMD1 protein, humanMembrane ProteinsReceptors, VasopressinSLC26A7 protein, humanSulfate TransportersTumor Suppressor Proteins

Identifiers

PMID31127295
PMCPMC6644157
OpenAlexW2937482092

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