ArticleScientific reports2019
Prevalence and characterization of Clostridium perfringens toxinotypes among patients with antibiotic-associated diarrhea in Iran.
Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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20 citing papers in PubMed, 1 synthesis or guideline pooled it, 32 citations in OpenAlex.
- A worldwide systematic review and meta-analysis of bacteria related to antibiotic-associated diarrhea in hospitalized patients.PloS one · 2021Pooled it
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- Microbiological Quality of Maize Silage in Relation to Agricultural Practices: A Four-Year Study.Foods (Basel, Switzerland) · 2026Article
- Prevalence and toxin gene profiles ofJournal of veterinary science · 2025Article
- Prevalence of epsilon toxin-producing Clostridium perfringens isolates among patients with multiple sclerosis and neuromyelitis optica spectrum disorder in Iran.BMC neurology · 2025Article
- Review
- Toxigenic Clostridium perfringens Isolated from At-Risk Paediatric Inflammatory Bowel Disease Patients.Journal of Crohn's & colitis · 2024Article
- Clostridial Myonecrosis: A Comprehensive Review of Toxin Pathophysiology and Management Strategies.Microorganisms · 2024Review
- Emergence of genetic diversity and multi-drug resistant Clostridium perfringens from wild birds.BMC veterinary research · 2024Article
- Clostridium perfringens in central Colombia: frequency, toxin genes, and risk factors.Gut pathogens · 2024Article
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- Genome characteristics of themSystems · 2023Article
- Prevalence and Characterisation ofMicroorganisms · 2023Article
- Molecular characteristics and phylogenetic analysis ofFrontiers in microbiology · 2023Article
- Design of a chitosan-based nano vaccine against epsilon toxin ofResearch in pharmaceutical sciences · 2021Article
- Diversity and Composition of Gut Bacterial Community in Giant Panda with Anorexia.Current microbiology · 2021Article
- Prevalence and Genetic Diversity ofInfection and drug resistance · 2021Article
- Toxin typing ofArchives of Razi Institute · 2021Article
- Treatment of RecurrentJournal of inflammation research · 2020Article
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Clostridium perfringens has emerged as an important cause of antibiotic-associated diarrhea (AAD), particularly in the hospital environment. Here we investigated the prevalence and molecular epidemiology of C. perfringens isolated from 2280 fecal samples from Iranian diarrheal patients suspected of having AAD. Overall, AAD was diagnosed in 13.3% (303/2280) of patients and associated with advanced age (>50 years, P = 0.001). A total of 106 C. perfringens isolates were cultured from AAD (n = 68) and non-AAD (n = 38) groups, with toxinotypes A and F comprising 84% and 16% of isolates, respectively. Notably, 41.2% of type F strains were also cpb2-positive and enterotoxigenic cpe-positive strains were detected in 13.2% of the isolates from AAD patients. Genes associated with the VirR/VirS signal transduction (virR, virS) and accessory gene regulator (agrB, agrD) systems were detected in 56.6% and 67% of the isolates, respectively, and peptides of the quorum-sensing modulator, AgrD were highly conserved across all strains. The high prevalence of C. perfringens in Iranian AAD patients suggests that diagnostic laboratories in this region should consider screening for C. perfringens in cases of suspected AAD, especially if the specimen is negative for other pathogens and/or the patients are aged >50 years.
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