ArticleScientific reports2019
Association between depressive-symptom trajectories and cognitive function in the late middle-aged and older population: results of the Korean Longitudinal Study of Ageing.
Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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18 citing papers in PubMed.
- Exploring blood-based biomarkers in late-life depression: Correlates of psychotherapeutic treatment outcomes.European psychiatry : the journal of the Association of European Psychiatrists · 2026Trial
- Positive affect disrupts neurodegeneration effects on cognitive training plasticity in older adults.Social cognitive and affective neuroscience · 2024Trial
- Posttraumatic stress disorder, major depression, and mild cognitive impairment: A cohort study of world trade center responders.Psychiatry research · 2026Article
- Sex-specific association of depressive symptom trajectories with cognitive decline and clinical progression in mild cognitive impairment.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Depressive intensity, duration, and their associations with cognitive decline: a population-based study in Korea.GeroScience · 2025Article
- Multitrajectories of Frailty and Depression With Cognitive Function: Findings From the Health and Retirement Longitudinal Study.Journal of cachexia, sarcopenia and muscle · 2025Article
- Persistent depressive symptom trajectory is associated with cognitive impairment: a population-based longitudinal study of aging in Taiwan.BMC geriatrics · 2025Article
- The Mediating Role of Cognitive Function in the Relationship Between Physical Performance and Depressive Symptoms Among Older Adults in China: A Prospective Longitudinal Study.Nursing research and practice · 2025Article
- Trajectories in depressive symptoms and midlife brain health.Translational psychiatry · 2024Article
- Regional differences in the effects of healthy aging on depressive symptoms: a Korean longitudinal study of aging (2006-2020).Frontiers in public health · 2024Article
- The mediating effect of leisure activities in the relationship between depression and cognitive decline in middle age and older adults in Taiwan.BMC geriatrics · 2023Article
- Sub-national patterns and correlates of depression among adults aged 45 years and older: findings from wave 1 of the Longitudinal Ageing Study in India.The lancet. Psychiatry · 2022Article
- Trajectories of depressive symptoms among community-dwelling Korean older adults: findings from the Korean longitudinal study of aging (2006-2016).BMC psychiatry · 2022Article
- Longitudinal Association Between Depressive Symptoms and Cognitive Function Among Older Adults: A Latent Growth Curve Modeling Approach.International journal of public health · 2022Article
- The higher levels of self-reported satisfaction, the lower risk of depressive symptoms: Evidence from a nationwide cross-sectional study in China.Frontiers in medicine · 2022Article
- Predictors of Changes in Cognitive Function in Older Korean Adults: The 2006-2018 Korean Longitudinal Study of Aging.International journal of environmental research and public health · 2021Article
- Could α-Klotho Unlock the Key Between Depression and Dementia in the Elderly: from Animal to Human Studies.Molecular neurobiology · 2021Review
- Trajectories of depressive symptoms and associated patterns of cognitive decline.Scientific reports · 2020Article
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6 authors.
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Abstract
This study investigated the association between depressive symptoms and cognitive function according to four different trajectories of depressive symptoms in the late middle-aged and older South Korean population. Panel data from the Korean Longitudinal Study of Ageing were analyzed. We used latent class trajectory models to identify four trajectories of depressive symptoms. We performed linear mixed-effects regression analysis to assess associations between depressive-symptom trajectories and MMSE scores. Of 4,374 participants, 18.4%, 4.9%, 55.2%, and 21.5% were classified as having a low, increasing, moderate declining, and high depressive-symptom trajectory, respectively. Individuals with an increasing trajectory (β = -0.729, P ≤ 0.001), moderate trajectory (β = -0.278, P = 0.003), and high trajectory (β = -1.605, P ≤ 0.001) had lower MMSE scores compared with those in the low trajectory group. These relationships were particularly strong among women; individuals who were physically inactive; those who were separated, divorced, or single; and those with hypertension or cerebrovascular disease. Each trajectory group for depressive symptoms was associated with cognitive decline. Moreover, female, physically inactive, and single individuals, as well as those with hypertension and cerebrovascular disease should be particularly mindful of their mental and physical health to prevent cognitive decline.
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