ArticleScientific reports2019
Honey bee predisposition of resistance to ubiquitous mite infestations.
Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 31 citations in OpenAlex.
- The symbiotic bacteriaMicrobiology spectrum · 2026Article
- Multi-Genome-Wide association studies provide new insights into the genetic architecture of Varroa resistance in honeybees.BMC genomics · 2025Article
- Article
- Article
- Allele Frequencies of Genetic Variants Associated with Varroa Drone Brood Resistance (DBR) inInsects · 2024Article
- Comprehensive Approach to PhenotypeInsects · 2024Article
- Population-wide modelling reveals prospects of marker-assisted selection for parasitic mite resistance in honey bees.Scientific reports · 2024Article
- Expression of Molecular Markers of Resilience againstInsects · 2023Article
- A genotyping by sequencing approach can disclose Apis mellifera population genomic information contained in honey environmental DNA.Scientific reports · 2022Article
- Decreased Mite Reproduction to Select Varroa destructor (Acari: Varroidae) Resistant Honey Bees (Hymenoptera: Apidae): Limitations and Potential Methodological Improvements.Journal of economic entomology · 2022Article
- Article
- qPCR assays with dual-labeled probes for genotyping honey bee variants associated with varroa resistance.BMC veterinary research · 2021Article
- Host-Parasite Co-Evolution in Real-Time: Changes in Honey Bee Resistance Mechanisms and Mite Reproductive Strategies.Insects · 2021Article
- Association between the Microsatellite Ap243, AC117 and SV185 Polymorphisms andVeterinary sciences · 2020Article
- Review
- Improving bee health through genomics.Nature reviews. Genetics · 2020Review
- Natural selection, selective breeding, and the evolution of resistance of honeybees (Zoological letters · 2020Review
- Factors restraining the population growth of Varroa destructor in Ethiopian honey bees (Apis mellifera simensis).PloS one · 2019Article
Corrections and comments
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Authors and funding
14 authors at 5 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Host-parasite co-evolution history is lacking when parasites switch to novel hosts. This was the case for Western honey bees (Apis mellifera) when the ectoparasitic mite, Varroa destructor, switched hosts from Eastern honey bees (Apis cerana). This mite has since become the most severe biological threat to A. mellifera worldwide. However, some A. mellifera populations are known to survive infestations, largely by suppressing mite population growth. One known mechanism is suppressed mite reproduction (SMR), but the underlying genetics are poorly understood. Here, we take advantage of haploid drones, originating from one queen from the Netherlands that developed Varroa-resistance, whole exome sequencing and elastic-net regression to identify genetic variants associated with SMR in resistant honeybees. An eight variants model predicted 88% of the phenotypes correctly and identified six risk and two protective variants. Reproducing and non-reproducing mites could not be distinguished using DNA microsatellites, which is in agreement with the hypothesis that it is not the parasite but the host that adapted itself. Our results suggest that the brood pheromone-dependent mite oogenesis is disrupted in resistant hosts. The identified genetic markers have a considerable potential to contribute to a sustainable global apiculture.
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