Evidence map›Paper›PMID 31127095›Full record

ArticleNature communications2019

Resting brain dynamics at different timescales capture distinct aspects of human behavior.

Raphaël Liégeois, Jingwei Li, Ru Kong, Csaba Orban, Dimitri Van De Ville, Tian Ge, Mert R Sabuncu, B T Thomas Yeo

Abstract read
In one paragraph

Article in Nature communications, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 154 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
154citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

154 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Neurobiology of loneliness: a systematic review.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2021
    Pooled it
  4. Sharp and smooth state transitions during resting state brain dynamics.bioRxiv : the preprint server for biology · 2026
    Article
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  8. Cognitive Processing and EEG Complexity.Entropy (Basel, Switzerland) · 2026
    Review
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94 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Raphaël LiégeoisDepartment of Electrical and Computer Engineering, Clinical Imaging Research Centre, N.1 Institute for Health and Memory Networks Program, National University of Singapore, Singapore, 117583, Singapore. Raphael.Liegeois@epfl.ch.ORCID http://orcid.org/0000-0003-3985-3898
Jingwei LiDepartment of Electrical and Computer Engineering, Clinical Imaging Research Centre, N.1 Institute for Health and Memory Networks Program, National University of Singapore, Singapore, 117583, Singapore.ORCID http://orcid.org/0000-0002-6395-8801
Ru KongDepartment of Electrical and Computer Engineering, Clinical Imaging Research Centre, N.1 Institute for Health and Memory Networks Program, National University of Singapore, Singapore, 117583, Singapore.
Csaba OrbanDepartment of Electrical and Computer Engineering, Clinical Imaging Research Centre, N.1 Institute for Health and Memory Networks Program, National University of Singapore, Singapore, 117583, Singapore.ORCID http://orcid.org/0000-0001-9133-3561
Dimitri Van De VilleInstitute of Bioengineering, Centre for Neuroprosthetics, École Polytechnique Fédérale de Lausanne, 1015, Lausanne, Switzerland.ORCID http://orcid.org/0000-0002-2879-3861
Tian GePsychiatric & Neurodevelopmental Genetics Unit, Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, 02114, USA.
Mert R SabuncuSchool of Electrical and Computer Engineering, Cornell University, Ithaca, NY, 14853, USA.
B T Thomas YeoDepartment of Electrical and Computer Engineering, Clinical Imaging Research Centre, N.1 Institute for Health and Memory Networks Program, National University of Singapore, Singapore, 117583, Singapore. Thomas.Yeo@nus.edu.sg.

Funding

NINDS CENTER CORE FOR BRAIN IMAGINGP30NS098577 · NINDS · WASHINGTON UNIVERSITY · PI AN, HONGYU · 2016 to 2019
$2.4M
Exploring the genetic basis of AD progressionR00AG054573 · NIA · MASSACHUSETTS GENERAL HOSPITAL · PI GE, TIAN · 2020 to 2022
$732k
Exploring the genetic basis of AD progressionK99AG054573 · NIA · MASSACHUSETTS GENERAL HOSPITAL · PI GE, TIAN · 2017 to 2018
$274k
NIA NIH HHS K99 AG054573NIA NIH HHS R00 AG054573NINDS NIH HHS P30 NS098577
6 · The paper itself

Abstract

Linking human behavior to resting-state brain function is a central question in systems neuroscience. In particular, the functional timescales at which different types of behavioral factors are encoded remain largely unexplored. The behavioral counterparts of static functional connectivity (FC), at the resolution of several minutes, have been studied but behavioral correlates of dynamic measures of FC at the resolution of a few seconds remain unclear. Here, using resting-state fMRI and 58 phenotypic measures from the Human Connectome Project, we find that dynamic FC captures task-based phenotypes (e.g., processing speed or fluid intelligence scores), whereas self-reported measures (e.g., loneliness or life satisfaction) are equally well explained by static and dynamic FC. Furthermore, behaviorally relevant dynamic FC emerges from the interconnections across all resting-state networks, rather than within or between pairs of networks. Our findings shed new light on the timescales of cognitive processes involved in distinct facets of behavior.

Indexed as

Models, NeurologicalAdultBehaviorBrainCognitionConnectomeHealthy VolunteersHumansImage Processing, Computer-AssistedMagnetic Resonance ImagingNerve NetRestTime FactorsYoung Adult

Identifiers

PMID31127095
PMCPMC6534566

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.