Evidence map›Paper›PMID 31127076›Full record

Trial reportAging2019

Comparison between physical and cognitive treatment in patients with MCI and Alzheimer's disease.

Cristina Fonte, Nicola Smania, Anna Pedrinolla, Daniele Munari, Marialuisa Gandolfi, Alessandro Picelli, Valentina Varalta, Maria V Benetti, Annalisa Brugnera, Angela Federico and 4 more

Open access · hybridAbstract readComparative StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Aging, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers, 14 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
46citing papers in PubMed, 14 pooled it
3.6field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

46 citing papers in PubMed, 14 syntheses or guidelines pooled it, 87 citations in OpenAlex.

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  3. The effect of exercise on the improvement of verbal fluency, spatial working memory, and the three major executive functions in elderly alzheimer's patients: a systematic review and meta-analysis.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 2 institutions in 2 countries.

Cristina FonteNeuromotor and Cognitive Rehabilitation Research Centre, Department of Neurosciences, Biomedicine and Movement Sciences, University of Verona, Verona, Italy.
Nicola SmaniaNeuromotor and Cognitive Rehabilitation Research Centre, Department of Neurosciences, Biomedicine and Movement Sciences, University of Verona, Verona, Italy.
Anna PedrinollaDepartment of Neurosciences, Biomedicine and Movement Sciences, University of Verona, Verona, Italy.
Daniele MunariNeuromotor and Cognitive Rehabilitation Research Centre, Department of Neurosciences, Biomedicine and Movement Sciences, University of Verona, Verona, Italy.
Marialuisa GandolfiNeuromotor and Cognitive Rehabilitation Research Centre, Department of Neurosciences, Biomedicine and Movement Sciences, University of Verona, Verona, Italy.
Alessandro PicelliNeuromotor and Cognitive Rehabilitation Research Centre, Department of Neurosciences, Biomedicine and Movement Sciences, University of Verona, Verona, Italy.
Valentina VaraltaNeuromotor and Cognitive Rehabilitation Research Centre, Department of Neurosciences, Biomedicine and Movement Sciences, University of Verona, Verona, Italy.
Maria V BenettiDepartment of Neurosciences, Biomedicine and Movement Sciences, University of Verona, Verona, Italy.
Annalisa BrugneraDepartment of Neurosciences, Biomedicine and Movement Sciences, University of Verona, Verona, Italy.
Angela FedericoDepartment of Neurosciences, Biomedicine and Movement Sciences, University of Verona, Verona, Italy.
Ettore MutiMons. A. Mazzali Foundation, Mantua, Italy.
Stefano TamburinDepartment of Neurosciences, Biomedicine and Movement Sciences, University of Verona, Verona, Italy.
Federico SchenaDepartment of Neurosciences, Biomedicine and Movement Sciences, University of Verona, Verona, Italy.
Massimo VenturelliDepartment of Neurosciences, Biomedicine and Movement Sciences, University of Verona, Verona, Italy.
University of Verona · ITFondazione Mons Arrigo Mazzali · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cognitive and physical activity treatments (CT and PT) are two non-pharmacological approaches frequently used in patients with Mild Cognitive Impairment (MCI) and Alzheimer's Disease (AD). The aim of this study was to compare CT and PT in these diseases. Eighty-seven patients were randomly assigned to CT (n=30), PT (n=27) or control group (CTRL; n=30) for 6 months. The global cognitive function was measured by Mini Mental State Examination (MMSE). Specific neuropsychological tests explored attention, memory, executive functions, behavioral disorders. Cardiovascular risk factors (CVD) were collected. All measures were performed before (T0), after treatments (T1), and at three-months follow-up (T2). MMSE did not change from T0 to T1 and T2 in patients assigned to PT and CT, while CTRL patients showed a decline MCI: -11.8%, AD: -16.2%). Between group differences (MCI vs AD) were not found at T1 and T2. Significant worsening was found for CTRL in MCI (T0- T1:

Indexed as

CognitionAgedAged, 80 and overAlzheimer DiseaseCognitive Behavioral TherapyCognitive DysfunctionExercise TherapyExercise ToleranceFemaleHumansMaleTreatment OutcomeAlzheimer’s diseasecognitive therapydementiamini-mental state examinationphysical activity

Identifiers

PMID31127076
PMCPMC6555450
OpenAlexW2945930122

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.