ArticleProceedings of the National Academy of Sciences of the United States of America2019
Comparative transcriptomics of 3 high-altitude passerine birds and their low-altitude relatives.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 47 papers.
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47 citing papers in PubMed, 85 citations in OpenAlex.
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- Seasonal transcriptome profile across three different tissues of the Andean Killifish Orestias ascotanensis.Scientific data · 2025Article
- Divergent Cardiovascular Adaptations and Gene Regulation in High-Elevation Natives and Recent Colonizers of the Qinghai-Tibetan Plateau.Molecular biology and evolution · 2025Article
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- In search of epigenetic hallmarks of different tissues: an integrative omics study of horse liver, lung, and heart.Mammalian genome : official journal of the International Mammalian Genome Society · 2024Article
- Tissue-specific and cis-regulatory changes underlie parallel, adaptive gene expression evolution in house mice.PLoS genetics · 2024Article
- Convergent genomics and Arctic adaptation of ruminants.Proceedings. Biological sciences · 2024Article
- High-altitude environments enhance the ability ofFrontiers in microbiology · 2024Article
- Genomic Variation, Population History, and Long-Term Genetic Adaptation to High Altitudes in Tibetan Partridge (Perdix hodgsoniae).Molecular biology and evolution · 2023Article
- Genome assembly of the foot-flagging frog, Staurois parvus: a resource for understanding mechanisms of behavior.G3 (Bethesda, Md.) · 2023Article
- Enlarged fins of Tibetan catfish provide new evidence of adaptation to high plateau.Science China. Life sciences · 2023Article
Corrections and comments
- Erratum issued
Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
High-altitude environments present strong stresses for living organisms, which have driven striking phenotypic and genetic adaptations. While previous studies have revealed multiple genetic adaptations in high-altitude species, how evolutionary history (i.e., phylogenetic background) contributes to similarity in genetic adaptations to high-altitude environments is largely unknown, in particular in a group of birds. We explored this in 3 high-altitude passerine birds from the Qinghai-Tibet Plateau and their low-altitude relatives in lowland eastern China. We generated transcriptomic data for 5 tissues across these species and compared sequence changes and expression shifts between high- and low-altitude pairs. Sequence comparison revealed that similarity in all 3 high-altitude species was high for genes under positive selection (218 genes) but low in amino acid substitutions (only 4 genes sharing identical amino acid substitutions). Expression profiles for all genes identified a tissue-specific expression pattern (i.e., all species clustered by tissue). By contrast, an altitude-related pattern was observed in genes differentially expressed between all 3 species pairs and genes associated with altitude, suggesting that the high-altitude environment may drive similar expression shifts in the 3 high-altitude species. Gene expression level, gene connectivity, and the interactions of these 2 factors with altitude were correlated with evolutionary rates. Our results provide evidence for how gene sequence changes and expression shifts work in a concerted way in a group of high-altitude birds, leading to similar evolution routes in response to high-altitude environmental stresses.
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