ArticleJournal of immunology (Baltimore, Md. : 1950)2019
Evidence of Trained Immunity in a Fish: Conserved Features in Carp Macrophages.
Article in Journal of immunology (Baltimore, Md. : 1950), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 75 citations in OpenAlex.
- Trained immunity induction by β-glucan under distinct immune training schemes in a mouse model.Immunologic research · 2026Article
- Postbiotics and Paraprobiotics as Next-Generation Gut Microbiome Modulators in Sustainable Aquaculture Health.Antibiotics (Basel, Switzerland) · 2026Review
- Glucuronolactone Alleviates Metabolic Stress Induced by High-Fat Diet in Turbot (Antioxidants (Basel, Switzerland) · 2026Article
- β-Glucan training induces stimulus-dependent immune and metabolic modulation in head kidney leukocytes that persists for several days in Atlantic salmon (Frontiers in immunology · 2026Article
- Dietary 1.3-1.6 yeast β-glucans enhance immune response and disease resilience in European seabass challenged withFrontiers in immunology · 2026Article
- Review
- Trained immunity in farm animals.Veterinary research · 2025Review
- Immune Response of Nile Tilapia (Oreochromis niloticus) Vaccinated With Diatom-Based Oral Vaccines Against Piscine Francisellosis.Journal of fish diseases · 2025Article
- Integrating Subacute Ruminal Acidosis, Lipopolysaccharide, and Trained Immunity: A Comprehensive Review.International journal of biological sciences · 2025Review
- GCRV-II invades monocytes/macrophages and induces macrophage polarization and apoptosis in tissues to facilitate viral replication and dissemination.Journal of virology · 2024Article
- Innate and germline immune memory: specificity and heritability of the ancient immune mechanisms for adaptation and survival.Frontiers in immunology · 2024Review
- Article
- Extracellular trap can be trained as a memory response.Virulence · 2022Article
- Trained Immunity Provides Long-Term Protection against Bacterial Infections in Channel Catfish.Pathogens (Basel, Switzerland) · 2022Article
- The Relapse of Psoriasis: Mechanisms and Mysteries.JID innovations : skin science from molecules to population health · 2022Review
- Transgenerational Effects of Maternal Immune Activation on Specific Antibody Responses in Layer Chickens.Frontiers in veterinary science · 2022Article
- Trained Immunity as an Adaptive Branch of Innate Immunity.International journal of molecular sciences · 2021Review
- Exogenous enzymes and probiotics alter digestion kinetics, volatile fatty acid content and microbial interactions in the gut of Nile tilapia.Scientific reports · 2021Article
- Epidermal Club Cells in Fishes: A Case for Ecoimmunological Analysis.International journal of molecular sciences · 2021Review
- β-Glucan-Induced Immuno-Modulation: A Role for the Intestinal Microbiota and Short-Chain Fatty Acids in Common Carp.Frontiers in immunology · 2021Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Trained immunity is a form of innate immune memory best described in mice and humans. Clear evidence of the evolutionary conservation of trained immunity in teleost fish is lacking. Given the evolutionary position of teleosts as early vertebrates with a fully developed immune system, we hypothesize that teleost myeloid cells show features of trained immunity common to those observed in mammalian macrophages. These would at least include the ability of fish macrophages to mount heightened responses to a secondary stimulus in a nonspecific manner. We established an in vitro model to study trained immunity in fish by adapting a well-described culture system of head kidney-derived macrophages of common carp. A soluble NOD-specific ligand and a soluble β-glucan were used to train carp macrophages, after which cells were rested for 6 d prior to exposure to a secondary stimulus. Unstimulated trained macrophages displayed evidence of metabolic reprogramming as well as heightened phagocytosis and increased expression of the inflammatory cytokines
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.