Evidence map›Paper›PMID 31127025›Full record

ArticleBioscience reports2019

LIFR-AS1 modulates Sufu to inhibit cell proliferation and migration by miR-197-3p in breast cancer.

Fangfang Xu, Hui Li, Chengjiu Hu

RetractedOpen access · goldAbstract readRetracted Publication
In one paragraph

Article in Bioscience reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
2.4field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 40 citations in OpenAlex.

  1. Article
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  3. Upregulation ofGenes · 2024
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  17. MCell cycle (Georgetown, Tex.) · 2021
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Fangfang XuDepartment of Pathology, Jining No.1 People’s Hospital, Jining 272011, China
Hui LiDepartment of Oncology, Affiliated Hospital of Jining Medical University, Jining 272100, China
Chengjiu HuDepartment of Pathology, Jining No.1 People’s Hospital, Jining 272011, China cjhu0410@163.com.ORCID 0000-0002-3537-0525
Affiliated Hospital of Jining Medical University · CNJining First People's Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Numerous evidence has recently demonstrated that long non-coding RNAs (lncRNAs) play vital roles in the oncogenesis and development of a wide range of human neoplasms. Leukemia inhibitory factor receptor antisense RNA 1 (LIFR-AS1), a novel cancer-related lncRNA, has been reported to be under-expressed in breast cancer and associated with poor prognosis. However, the exact role of LIFR-AS1 in breast cancer remains largely unclear. The present study aimed to investigate the biological role of LIFR-AS1 in breast cancer and clarify the potential molecular mechanisms. In the present study, we found that LIFR-AS1 was significantly down-regulated in both tissues and cell lines. Furthermore, over-expression of LIFR-AS1 inhibited breast cancer cell proliferation, colony formation, migration and invasion, whereas knockdown of LIFR-AS1 promoted breast cancer cell proliferation, colony formation, migration and invasion. Moreover, LIFR-AS1 was observed to up-regulate suppressor of fused gene (

Indexed as

AnimalsBreast NeoplasmsCell MovementCell ProliferationFemaleGene Expression Regulation, NeoplasticHeterograftsHumansMCF-7 CellsMiceMicroRNAsNeoplasm InvasivenessRepressor ProteinsRNA, Long NoncodingMicroRNAsMIRN197 microRNA, humanRepressor ProteinsRNA, Long NoncodingSUFU protein, humanbreast cancercell migrationLIFR-AS1miR-197-3pSufu

Identifiers

PMID31127025
PMCPMC6614576
OpenAlexW2946145370

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.