Evidence map›Paper›PMID 31126961›Full record

ReviewClinical cancer research : an official journal of the American Association for Cancer Research2019

Advancing Drug Development in Gynecologic Malignancies.

Julia A Beaver, Robert L Coleman, Rebecca C Arend, Deborah K Armstrong, Sanjeeve Bala, Gordon B Mills, Anil K Sood, Thomas J Herzog

Open access · greenAbstract readReview
In one paragraph

Review in Clinical cancer research : an official journal of the American Association for Cancer Research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
3.6field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 23 citations in OpenAlex.

  1. Trial
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. U.S. FDA Drug Approvals for Gynecological Malignancies: A Decade in Review.Clinical cancer research : an official journal of the American Association for Cancer Research · 2022
    Review
  9. Overexpression ofDisease markers · 2022
    Article
  10. Review
  11. Article
  12. Article
  13. Article
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 6 institutions in 1 country.

Julia A Beaver *FDA Center for Drug Evaluation and Research, Silver Spring, Maryland.
Robert L Coleman *Department of Gynecologic Oncology and Reproductive Medicine, University of Texas MD Anderson Cancer Center, Houston, Texas.
Rebecca C ArendDepartment of Obstetrics and Gynecology, University of Alabama at Birmingham School of Medicine, Birmingham, Alabama.ORCID 0000-0003-2108-3426
Deborah K ArmstrongJohns Hopkins Sidney Kimmel Comprehensive Cancer Center, Baltimore, Maryland.
Sanjeeve BalaFDA Center for Drug Evaluation and Research, Silver Spring, Maryland.
Gordon B MillsKnight Cancer Institute, Oregon Health & Science University, Portland, Oregon.ORCID 0000-0002-0144-9614
Anil K SoodDepartments of Gynecologic Oncology and Cell Biology, University of Texas MD Anderson Cancer Center, Houston Texas.
Thomas J HerzogUniversity of Cincinnati Cancer Institute, Cincinnati, Ohio. HERZOGTJ@ucmail.uc.edu.
Center for Drug Evaluation and Research · USThe University of Texas MD Anderson Cancer Center · USOregon Health & Science University · USSidney Kimmel Comprehensive Cancer Center · USUniversity of Alabama at Birmingham · USUniversity of Cincinnati · US

Funding

Tumor Evolution and Metastasis ProgramP30CA016672 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI Scott Kopetz · 1985 to 2026
$290.8M
Targeting the PI3K Signaling Pathway in Endometrial CarcinomaP50CA098258 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI BODURKA, DIANE · 2003 to 2020
$32.0M
U.T. M. D. Anderson Cancer Center SPORE in Ovarian CancerP50CA217685 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI SOOD, ANIL K · 2017 to 2021
$7.9M
Harnessing the power of exosomes for non-coding RNA deliveryR35CA209904 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI SOOD, ANIL K · 2017 to 2023
$5.0M
Integrative bioinformatics and functional characterization of oncogenic driver aberrations in cancerU01CA217842 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI DENEEN, BENJAMIN, MILLS, GORDON B. · 2017 to 2021
$3.6M
NCI NIH HHS P30 CA016672NCI NIH HHS P50 CA098258NCI NIH HHS P50 CA217685NCI NIH HHS R35 CA209904NCI NIH HHS U01 CA217842
6 · The paper itself

Abstract

Gynecologic malignancies continue to be a major cause of morbidity and mortality in the United States despite recent advances in oncologic therapies. To realize the promise of immunotherapy and biomarker-driven approaches to improve clinical outcomes for patients, better communication among stakeholders in the drug development and approval pathways is needed. To this end, the FDA-AACR-SGO Drug Development in Gynecologic Malignancies Workshop brought together clinicians, patient advocates, researchers, industry representatives, and regulators in June 2018, to review the state of the science in gynecologic cancers and explore how scientific advances impact approval processes. Topics of discussion and key takeaways are summarized in this

Indexed as

Drug DevelopmentAntineoplastic AgentsAntineoplastic Agents, ImmunologicalBiomarkers, TumorClinical Trials as TopicCombined Modality TherapyFemaleGenital Neoplasms, FemaleHumansImmunotherapyMolecular Targeted TherapyResearch DesignTreatment OutcomeAntineoplastic AgentsAntineoplastic Agents, ImmunologicalBiomarkers, Tumor

Identifiers

PMID31126961
PMCPMC6697564
OpenAlexW2946691757

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.