Evidence map›Paper›PMID 31126916›Full record

ArticleBlood advances2019

Gene expression signature that predicts early molecular response failure in chronic-phase CML patients on frontline imatinib.

Chung H Kok, David T Yeung, Liu Lu, Dale B Watkins, Tamara M Leclercq, Phuong Dang, Verity A Saunders, John Reynolds, Deborah L White, Timothy P Hughes

Abstract read
In one paragraph

Article in Blood advances, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Chung H KokPrecision Medicine Theme, South Australia Health and Medical Research Institute, Adelaide, SA, Australia.ORCID 0000-0002-3181-7852
David T YeungPrecision Medicine Theme, South Australia Health and Medical Research Institute, Adelaide, SA, Australia.ORCID 0000-0002-7558-9927
Liu LuPrecision Medicine Theme, South Australia Health and Medical Research Institute, Adelaide, SA, Australia.
Dale B WatkinsPrecision Medicine Theme, South Australia Health and Medical Research Institute, Adelaide, SA, Australia.
Tamara M LeclercqPrecision Medicine Theme, South Australia Health and Medical Research Institute, Adelaide, SA, Australia.
Phuong DangPrecision Medicine Theme, South Australia Health and Medical Research Institute, Adelaide, SA, Australia.
Verity A SaundersPrecision Medicine Theme, South Australia Health and Medical Research Institute, Adelaide, SA, Australia.
John ReynoldsAlfred Health and Faculty of Medicine, Nursing and Health Sciences, Monash University, Melbourne, VIC, Australia.
Deborah L WhitePrecision Medicine Theme, South Australia Health and Medical Research Institute, Adelaide, SA, Australia.ORCID 0000-0003-4844-333X
Timothy P HughesPrecision Medicine Theme, South Australia Health and Medical Research Institute, Adelaide, SA, Australia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In chronic-phase chronic myeloid leukemia (CP-CML) patients treated with frontline imatinib, failure to achieve early molecular response (EMR; EMR failure:

Indexed as

AdolescentAdultAgedFemaleHumansImatinib MesylateLeukemia, Myelogenous, Chronic, BCR-ABL PositiveMaleMiddle AgedProtein Kinase InhibitorsTranscriptomeTreatment OutcomeYoung AdultImatinib MesylateProtein Kinase Inhibitors

Identifiers

PMID31126916
PMCPMC6538873

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.